Agoulnik, Alexander

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Agoulnik, Alexander

Positions

Professor, Human and Molecular Genetics , Herbert Wertheim College of Medicine

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Patents issued

Materials and Methods for the Treatment of Vascular Calcification Patent
Modulators of the Relaxin Receptor 1 Patent
Modulators of the Relaxin Receptor 1 Patent

selected scholarly works & creative activities

Article
- 2024
  
  Engineering a long acting, non-biased relaxin agonist using Protein-in-Protein technology. BIOCHEMICAL PHARMACOLOGY. 227.
  Full Text via DOI: 10.1016/j.bcp.2024.116401 Web of Science: 001272867600001
- 2024
  
  AI is a viable alternative to high throughput screening: a 318-target study. SCIENTIFIC REPORTS. 14.
  Full Text via DOI: 10.1038/s41598-024-54655-z Web of Science: 001253148000001
- 2023
  
  The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors. BRITISH JOURNAL OF PHARMACOLOGY. 180:S23-S144.
  Full Text via DOI: 10.1111/bph.16177 Web of Science: 001158366700007
- 2023
  
  Relaxin family peptide receptors in GtoPdb v.2023.1
  Full Text via DOI: 10.2218/gtopdb/f60/2023.1
- 2022
  
  Discovery of small molecule agonists of the Relaxin Family Peptide Receptor 2
  Full Text via DOI: 10.1038/s42003-022-04143-9 Web of Science: 000879050900003
- 2022
  
  ODP010 Relaxin Receptor RXFP1 Knockout in Adipose Tissue Progenitor Cells Results in Resistance to High Fat Diet-Induced Weigh Gain
  Full Text via DOI: 10.1210/jendso/bvac150.024
- 2021
  
  Anti-apoptotic and Matrix Remodeling Actions of a Small Molecule Agonist of the Human Relaxin Receptor, ML290 in Mice With Unilateral Ureteral Obstruction. FRONTIERS IN PHYSIOLOGY. 12.
  Full Text via DOI: 10.3389/fphys.2021.650769 Web of Science: 000674951600001
- 2021
  
  INPP4B protects from metabolic syndrome and associated disorders
  Full Text via DOI: 10.1038/s42003-021-01940-6 Web of Science: 000635193900004
- 2020
  
  Abstract 17021: A Novel Human Relaxin Receptor Agonist, ML290, Attenuates Atherosclerosis- and Chronic Kidney Disease-Induced Vascular Calcification in Mice. CIRCULATION. 142.
  Full Text via DOI: 10.1161/circ.142.suppl_3.17021
- 2020
  
  GLI3 resides at the intersection of hedgehog and androgen action to promote male sex differentiation. PLOS GENETICS. 16.
  Full Text via DOI: 10.1371/journal.pgen.1008810 Web of Science: 000559723400013
- 2020
  
  Deletion of inositol polyphosphate 4-phosphatase type-II B affects spermatogenesis in mice. PLOS ONE. 15.
  Full Text via DOI: 10.1371/journal.pone.0233163 Web of Science: 000537496000052
- 2019
  
  Therapeutic effects of a small molecule agonist of the relaxin receptor ML290 in liver fibrosis. FASEB JOURNAL. 33:12435-12446.
  Full Text via DOI: 10.1096/fj.201901046R Web of Science: 000507461600065
- 2019
  
  INSL3 in the muscolo-skeletal system. MOLECULAR AND CELLULAR ENDOCRINOLOGY. 487:12-17.
  Full Text via DOI: 10.1016/j.mce.2018.12.021 Web of Science: 000463350300003
- 2019
  
  Small molecule allosteric agonist of relaxin receptor ML290 demonstrates antifibrotic properties in liver fibrosis
  Full Text via DOI: 10.1530/endoabs.63.gp223
- 2019
  
  Targeting the relaxin/insulin-like family peptide receptor 1 and 2 with small molecule compounds. MOLECULAR AND CELLULAR ENDOCRINOLOGY. 487:40-44.
  Full Text via DOI: 10.1016/j.mce.2018.12.013 Web of Science: 000463350300007
- 2019
  
  SAT-035 Small Molecule Allosteric Agonist of Relaxin Receptor Ml290 Demonstrates Antifibrotic Properties in Liver Fibrosis
  Full Text via DOI: 10.1210/js.2019-sat-035
- 2019
  
  SAT-326 INPP4B Suppresses Prostate Inflammation And Protects Mice Fed With High-fat Diet From The Development Of Prostate Intraepithelial Neoplasia
  Full Text via DOI: 10.1210/js.2019-sat-326
- 2018
  
  Relaxin receptor deficiency promotes vascular inflammation and impairs outward remodeling in arteriovenous fistulas. FASEB JOURNAL. 32:6293-6304.
  Full Text via DOI: 10.1096/fj.201800437R Web of Science: 000447172000043
- 2018
  
  Protective Role of Testicular Hormone INSL3 From Atrophy and Weakness in Skeletal Muscle. FRONTIERS IN ENDOCRINOLOGY. 9.
  Full Text via DOI: 10.3389/fendo.2018.00562 Web of Science: 000445896300001
- 2018
  
  Optimization of the first small-molecule relaxin/insulin-like family peptide receptor (RXFP1) agonists: Activation results in an antifibrotic gene expression profile. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 156:79-92.
  Full Text via DOI: 10.1016/j.ejmech.2018.06.008 Web of Science: 000443663200007
- 2017
  
  ML290 is a biased allosteric agonist at the relaxin receptor RXFP1. SCIENTIFIC REPORTS. 7.
  Full Text via DOI: 10.1038/s41598-017-02916-5 Web of Science: 000402879800024
- 2017
  
  Human Relaxin Receptor Is Fully Functional in Humanized Mice and Is Activated by Small Molecule Agonist ML290
  Full Text via DOI: 10.1210/js.2017-00112 Web of Science: 000425346100016
- 2017
  
  Therapeutic potentials of small molecular weight allosteric agonist of relaxin receptor
  Full Text via DOI: 10.1530/endoabs.49.ep754
- 2016
  
  Nuclear Receptor Corepressor 1 Expression and Output Declines with Prostate Cancer Progression. CLINICAL CANCER RESEARCH. 22:3937-3949.
  Full Text via DOI: 10.1158/1078-0432.CCR-15-1983 Web of Science: 000382265600026
- 2016
  
  Structural Insights into the Activation of Human Relaxin Family Peptide Receptor 1 by Small-Molecule Agonists. BIOCHEMISTRY. 55:1772-1783.
  Full Text via DOI: 10.1021/acs.biochem.5b01195 Web of Science: 000373247600011
- 2016
  
  Constitutive Notch Signaling Causes Abnormal Development of the Oviducts, Abnormal Angiogenesis, and Cyst Formation in Mouse Female Reproductive Tract. BIOLOGY OF REPRODUCTION. 94.
  Full Text via DOI: 10.1095/biolreprod.115.134569 Web of Science: 000405110600009
- 2015
  
  Activation of relaxin family receptor 1 from different mammalian species by relaxin peptide and small-molecule agonist ML290. FRONTIERS IN ENDOCRINOLOGY. 6.
  Full Text via DOI: 10.3389/fendo.2015.00128 Web of Science: 000378398700001
- 2015
  
  Genetic ablation of androgen receptor signaling in fetal Leydig cell lineage affects Leydig cell functions in adult testis. FASEB JOURNAL. 29:2327-2337.
  Full Text via DOI: 10.1096/fj.14-263632 Web of Science: 000355209500011
- 2015
  
  Conditional Deletion of the Relaxin Receptor Gene in Cells of Smooth Muscle Lineage Affects Lower Reproductive Tract in Pregnant Mice. BIOLOGY OF REPRODUCTION. 92.
  Full Text via DOI: 10.1095/biolreprod.114.127209 Web of Science: 000352712200009
- 2014
  
  Normal Fertility in Male Mice With Deletion of b-Catenin Gene in Germ Cells. GENESIS. 52:328-332.
  Full Text via DOI: 10.1002/dvg.22742 Web of Science: 000334349600005
- 2013
  
  Mechanisms of INSL3 signaling in male reproductive organs
- 2013
  
  The Fate of Spermatogonial Stem Cells in the Cryptorchid Testes of RXFP2 Deficient Mice. PLOS ONE. 8.
  Full Text via DOI: 10.1371/journal.pone.0077351 Web of Science: 000325483600086
- 2013
  
  NOTCH1 Gain of Function in Germ Cells Causes Failure of Spermatogenesis in Male Mice. PLOS ONE. 8.
  Full Text via DOI: 10.1371/journal.pone.0071213 Web of Science: 000323114200117
- 2013
  
  Identification of Small-Molecule Agonists of Human Relaxin Family Receptor 1 (RXFP1) by Using a Homogenous Cell-Based cAMP Assay. JOURNAL OF BIOMOLECULAR SCREENING. 18:670-677.
  Full Text via DOI: 10.1177/1087057112469406 Web of Science: 000320888100004
- 2013
  
  Identification and optimization of small-molecule agonists of the human relaxin hormone receptor RXFP1. NATURE COMMUNICATIONS. 4.
  Full Text via DOI: 10.1038/ncomms2953 Web of Science: 000323624100021
- 2013
  
  Left-sided cryptorchidism in mice with Wilms' tumour 1 gene deletion in gubernaculum testis. JOURNAL OF PATHOLOGY. 230:39-47.
  Full Text via DOI: 10.1002/path.4161 Web of Science: 000317434000006
- 2013
  
  Reduced Androgen Receptor Expression Accelerates the Onset of ERBB2 Induced Breast Tumors in Female Mice. PLOS ONE. 8.
  Full Text via DOI: 10.1371/journal.pone.0060455 Web of Science: 000317898000033
- 2012
  
  Insulin-Like 3 Signaling Is Important for Testicular Descent but Dispensable for Spermatogenesis and Germ Cell Survival in Adult Mice. BIOLOGY OF REPRODUCTION. 87.
  Full Text via DOI: 10.1095/biolreprod.112.103382 Web of Science: 000314234100016
- 2012
  
  Activation of the Notch Signaling Pathway Affects Development of the Reproductive Tract and Fertility in Female Mice.. BIOLOGY OF REPRODUCTION. 87:346-346.
  Full Text via DOI: 10.1093/biolreprod/87.s1.346
- 2012
  
  Rethinking dog domestication by integrating genetics, archeology, and biogeography. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 109:8878-8883.
  Full Text via DOI: 10.1073/pnas.1203005109 Web of Science: 000304991100028
- 2012
  
  Cryptorchidism in Mice with an Androgen Receptor Ablation in Gubernaculum Testis. MOLECULAR ENDOCRINOLOGY. 26:598-607.
  Full Text via DOI: 10.1210/me.2011-1283 Web of Science: 000302139800007
- 2012
  
  Relaxin increases human endothelial progenitor cell NO and migration and vasculogenesis in mice. BLOOD. 119:629-636.
  Full Text via DOI: 10.1182/blood-2011-04-346007 Web of Science: 000299268900043
- 2012
  
  Spermatogenesis in Cryptorchidism
  Full Text via DOI: 10.1007/978-1-61779-436-0_11 Web of Science: 000321932500012
- 2011
  
  Expression of LDL-A module of relaxin receptor in prostate cancer cells inhibits tumorigenesis. INTERNATIONAL JOURNAL OF ONCOLOGY. 39:1559-1565.
  Full Text via DOI: 10.3892/ijo.2011.1159 Web of Science: 000296315400023
- 2011
  
  Uterine Cysts in Female Mice Deficient for Caveolin-1 and Insulin-Like 3 Receptor RXFP2. ENDOCRINOLOGY. 152:2474-2482.
  Full Text via DOI: 10.1210/en.2010-1015 Web of Science: 000290788500034
- 2011
  
  Suppression of Insulin-Like3 Receptor Reveals the Role of beta-Catenin and Notch Signaling in Gubernaculum Development. MOLECULAR ENDOCRINOLOGY. 25:170-183.
  Full Text via DOI: 10.1210/me.2010-0330 Web of Science: 000285745800014
- 2011
  
  Suppression of Insulin-Like3 Receptor Reveals the Role of β-Catenin and Notch Signaling in Gubernaculum Development. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 96:239-239.
  Full Text via DOI: 10.1210/jcem.96.1.9995
- 2010
  
  Suppression of relaxin receptor RXFP1 decreases prostate cancer growth and metastasis. ENDOCRINE-RELATED CANCER. 17:1021-1033.
  Full Text via DOI: 10.1677/ERC-10-0073 Web of Science: 000284490000021
- 2010
  
  Hormonal Regulation of Testicular Descent.. BIOLOGY OF REPRODUCTION. 83:19-19.
  Full Text via DOI: 10.1093/biolreprod/83.s1.19
- 2010
  
  Ontogeny of the Relaxin Receptor (RXFP1) in the Female Mouse Reproductive Tract.. BIOLOGY OF REPRODUCTION. 83:365-365.
  Full Text via DOI: 10.1093/biolreprod/83.s1.365
- 2010
  
  INSL3 has tumor-promoting activity in thyroid cancer. INTERNATIONAL JOURNAL OF CANCER. 127:521-531.
  Full Text via DOI: 10.1002/ijc.25068 Web of Science: 000279131300004
- 2009
  
  Estrogen and TCDD Influence RLN2 Gene Activity in Estrogen Receptor-Positive Human Breast Cancer Cells. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 1160:367-373.
  Full Text via DOI: 10.1111/j.1749-6632.2009.03836.x Web of Science: 000265652100072
- 2009
  
  INSL3 Plays a Role in the Balance between Bone Formation and Resorption. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 1160:219-220.
  Full Text via DOI: 10.1111/j.1749-6632.2008.03785.x Web of Science: 000265652100043
- 2009
  
  INSL3/RXFP2 Signaling in Testicular Descent Mice and Men. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 1160:197-204.
  Full Text via DOI: 10.1111/j.1749-6632.2009.03841.x Web of Science: 000265652100039
- 2009
  
  New Roles for INSL3 in Adults Regulation of Bone Metabolism and Association of RXFP2 Gene Mutations with Osteoporosis. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 1160:215-218.
  Full Text via DOI: 10.1111/j.1749-6632.2008.03787.x Web of Science: 000265652100042
- 2009
  
  Normal prostate morphology in relaxin-mutant mice
  Full Text via DOI: 10.1071/RD08133 Web of Science: 000263836700007
- 2009
  
  Relative Roles of the Epithelial and Stromal Tissue Compartment(s) in Mediating the Actions of Relaxin and Estrogen on Cell Proliferation and Apoptosis in the Mouse Lower Reproductive Tract. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 1160:121-129.
  Full Text via DOI: 10.1111/j.1749-6632.2008.03799.x Web of Science: 000265652100023
- 2009
  
  Relaxin Signaling in Uterine Fibroids. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 1160:374-378.
  Full Text via DOI: 10.1111/j.1749-6632.2008.03803.x Web of Science: 000265652100073
- 2009
  
  Relaxin/RXFP1 Signaling in Prostate Cancer Progression. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 1160:379-380.
  Full Text via DOI: 10.1111/j.1749-6632.2008.03793.x Web of Science: 000265652100074
- 2008
  
  Mutations in the insulin-like factor 3 receptor are associated with osteoporosis
  Full Text via DOI: 10.1359/JBMR.080204 Web of Science: 000255203100011
- 2008
  
  Relaxin acts on stromal cells to promote epithelial and stromal proliferation and inhibit apoptosis in the mouse cervix and vagina. ENDOCRINOLOGY. 149:2072-2079.
  Full Text via DOI: 10.1210/en.2007-1176 Web of Science: 000255200000006
- 2007
  
  Developmental expression and gene regulation of insulin-like 3 receptor RXFP2 in mouse male reproductive organs. BIOLOGY OF REPRODUCTION. 77:671-680.
  Full Text via DOI: 10.1095/biolreprod.107.060442 Web of Science: 000249766700010
- 2007
  
  Novel mutations involving the INSL3 gene associated with cryptorchidism. JOURNAL OF UROLOGY. 177:1947-1951.
  Full Text via DOI: 10.1016/j.juro.2007.01.002 Web of Science: 000245764900088
- 2007
  
  Relaxin promotes prostate cancer progression. CLINICAL CANCER RESEARCH. 13:1695-1702.
  Full Text via DOI: 10.1158/1078-0432.CCR-06-2492 Web of Science: 000245031800013
- 2007
  
  The low-density lipoprotein class a module of the relaxin receptor (leucine-rich repeat containing G-protein coupled receptor 7): Its role in signaling and trafficking to the cell membrane. ENDOCRINOLOGY. 148:1181-1194.
  Full Text via DOI: 10.1210/en.2006-1086 Web of Science: 000244278100029
- 2007
  
  Relaxin and related peptides in male reproduction
  Web of Science: 000251961000006
- 2007
  
  T222P mutation of the insulin-like 3 hormone receptor LGR8 is associated with testicular maldescent and hinders receptor expression on the cell surface membrane
  Full Text via DOI: 10.1152/ajpendo.00228.2006 Web of Science: 000243253900019
- 2006
  
  Over expression of insulin-like 3 does not prevent cryptorchidism in GNRHR or HOXA10 deficient mice. JOURNAL OF UROLOGY. 176:399-404.
  Full Text via DOI: 10.1016/S0022-5347(06)00519-2 Web of Science: 000238298000098
- 2006
  
  Insulin-like factor 3 gene mutations in testicular dysgenesis syndrome: clinical and functional characterization
  Full Text via DOI: 10.1093/molehr/gal043 Web of Science: 000239387600006
- 2006
  
  Endocrine effects of relaxin overexpression in mice. ENDOCRINOLOGY. 147:407-414.
  Full Text via DOI: 10.1210/en.2005-0626 Web of Science: 000234053500045
- 2006
  
  The role of relaxin in endometrial cancer. CANCER BIOLOGY & THERAPY. 5:71-77.
  Full Text via DOI: 10.4161/cbt.5.1.2289 Web of Science: 000236044500020
- 2005
  
  Genetic targeting of relaxin and Insl3 signaling in mice. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 1041:82-90.
  Full Text via DOI: 10.1196/annals.1282.012 Web of Science: 000231831000013
- 2005
  
  INSL3/LGR8 role in testicular descent and cryptorchidism. REPRODUCTIVE BIOMEDICINE ONLINE. 10:49-54.
  Full Text via DOI: 10.1016/S1472-6483(10)60803-6 Web of Science: 000226449000004
- 2004
  
  Mutation analysis of Insl3 and Great/Lgr8 genes in familial cryptorchidism. UROLOGY. 64:1032-1036.
  Full Text via DOI: 10.1016/j.urology.2004.06.051 Web of Science: 000225218800053
- 2004
  
  Genetic targeting of relaxin and insulin-like factor 3 receptors in mice. ENDOCRINOLOGY. 145:4712-4720.
  Full Text via DOI: 10.1210/en.2004-0515 Web of Science: 000223885600035
- 2003
  
  GREAT/LGR8 is the only receptor for insulin-like 3 peptide. MOLECULAR ENDOCRINOLOGY. 17:2639-2646.
  Full Text via DOI: 10.1210/me.2003-0096 Web of Science: 000187072900021
- 2003
  
  Transabdominal testicular descent is disrupted in mice with deletion of insulinlike factor 3 receptor. JOURNAL OF PEDIATRIC SURGERY. 38:1793-1798.
  Full Text via DOI: 10.1016/j.jpedsurg.2003.08.047 Web of Science: 000187173100024
- 2003
  
  Isolation and expression analysis of the canine insulin-like factor 3 gene. BIOLOGY OF REPRODUCTION. 69:1658-1664.
  Full Text via DOI: 10.1095/biolreprod.103.019166 Web of Science: 000186147700027
- 2003
  
  A major locus on mouse chromosome 18 controls XX sex reversal in Odd Sex (Ods) mice. HUMAN MOLECULAR GENETICS. 12:509-515.
  Full Text via DOI: 10.1093/hmg/ddg045 Web of Science: 000181379600006
- 2002
  
  A novel gene, Pog, is necessary for primordial germ cell proliferation in the mouse and underlies the germ cell deficient mutation, gcd. HUMAN MOLECULAR GENETICS. 11:3047-3053.
  Full Text via DOI: 10.1093/hmg/11.24.3047 Web of Science: 000179120100006
- 2002
  
  Mutations of the GREAT gene cause cryptorchidism. HUMAN MOLECULAR GENETICS. 11:2309-2318.
  Full Text via DOI: 10.1093/hmg/11.19.2309 Web of Science: 000177999200012
- 2002
  
  Successful targeting of mouse Y chromosome genes using a site-directed insertion vector
  Full Text via DOI: 10.1002/gene.10020 Web of Science: 000173621800001
- 2001
  
  Identification and sequencing the juvenile spermatogonial depletion critical interval on mouse chromosome 1 reveals the presence of eight candidate genes. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 288:1129-1135.
  Full Text via DOI: 10.1006/bbrc.2001.5899 Web of Science: 000172467500010
- 2001
  
  Caveolin-1 is down-regulated in human ovarian carcinoma and acts as a candidate tumor suppressor gene. AMERICAN JOURNAL OF PATHOLOGY. 159:1635-1643.
  Full Text via DOI: 10.1016/S0002-9440(10)63010-6 Web of Science: 000171988000006
- 2001
  
  A transgenic insertion causing cryptorchidism in mice
  Full Text via DOI: 10.1002/gene.1029 Web of Science: 000169151600005
- 2001
  
  Down-regulation of caveolin-1, a candidate tumor suppressor gene, in sarcomas. AMERICAN JOURNAL OF PATHOLOGY. 158:833-839.
  Full Text via DOI: 10.1016/S0002-9440(10)64031-X Web of Science: 000167411100008
- 2001
  
  Smcy transgene does not rescue spermatogenesis in sex-reversed mice. MAMMALIAN GENOME. 12:112-116.
  Full Text via DOI: 10.1007/s003350010249 Web of Science: 000166684200004
- 2000
  
  A transgenic insertion upstream of Sox9 is associated with dominant XX sex reversal in the mouse
  Full Text via DOI: 10.1038/82652 Web of Science: 000165671700027
- 1999
  
  Mouse H-Y encoding Smcy gene and its X chromosomal homolog Smcx. MAMMALIAN GENOME. 10:926-929.
  Full Text via DOI: 10.1007/s003359901116 Web of Science: 000081997600015
- 1998
  
  Physical and genetic linkage of glutaminase (Gls), signal transducer and activator of transcription 1 (Stat1), and xeroderma pigmentosum complementation group G (Xpg) on mouse proximal chromosome 1
  Full Text via DOI: 10.1006/geno.1998.5532 Web of Science: 000077350500023
- 1998
  
  Evolution of the DAZ gene family suggests that Y-linked DAZ plays little, or a limited, role in spermatogenesis but underlines a recent African origin for human populations. HUMAN MOLECULAR GENETICS. 7:1371-1377.
  Full Text via DOI: 10.1093/hmg/7.9.1371 Web of Science: 000075713000005
- 1998
  
  Transposition of RhoA to the murine Y chromosome
  Full Text via DOI: 10.1006/geno.1998.5219 Web of Science: 000073656400002
- 1998
  
  Long-term T cell memory requires the surface expression of self-peptide major histocompatibility complex molecules. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 95:3065-3070.
  Full Text via DOI: 10.1073/pnas.95.6.3065 Web of Science: 000072596200065
- 1998
  
  A murine TSPY. CHROMOSOME RESEARCH. 6:35-40.
  Full Text via DOI: 10.1023/A:1009214307764 Web of Science: 000071700900005
- 1997
  
  In situ hybridization shows that Dazla expression in mouse testis is restricted to premeiotic stages IV-VI of spermatogenesis. MAMMALIAN GENOME. 8:277-278.
  Full Text via DOI: 10.1007/s003359900409 Web of Science: A1997WQ07000011
- 1997
  
  The HLA-A*0201-restricted H-Y antigen contains a posttranslationally modified cysteine that significantly affects T cell recognition
  Full Text via DOI: 10.1016/S1074-7613(00)80330-1 Web of Science: A1997XC61800007
- 1997
  
  Analysis of mutation rates in the SMCY/SMCX genes shows that mammalian evolution is male driven. MAMMALIAN GENOME. 8:134-138.
  Full Text via DOI: 10.1007/s003359900372 Web of Science: A1997WJ65900011
- 1997
  
  Absence of DAZ gene mutations in cases of non-obstructed azoospermia. MOLECULAR HUMAN REPRODUCTION. 3:55-59.
  Full Text via DOI: 10.1093/molehr/3.1.55 Web of Science: A1997XT38300007
- 1995
  
  HUMAN H-Y - A MALE-SPECIFIC HISTOCOMPATIBILITY ANTIGEN DERIVED FROM THE SMCY PROTEIN. SCIENCE. 269:1588-1590.
  Full Text via DOI: 10.1126/science.7667640 Web of Science: A1995RU81300046
- 1995
  
  IDENTIFICATION OF A MOUSE MALE-SPECIFIC TRANSPLANTATION ANTIGEN, H-Y. NATURE. 376:695-698.
  Full Text via DOI: 10.1038/376695a0 Web of Science: A1995RQ67200062
- 1994
  
  A MOUSE Y-CHROMOSOME GENE ENCODED BY A REGION ESSENTIAL FOR SPERMATOGENESIS AND EXPRESSION OF MALE-SPECIFIC MINOR HISTOCOMPATIBILITY ANTIGENS. HUMAN MOLECULAR GENETICS. 3:873-878.
  Full Text via DOI: 10.1093/hmg/3.6.873 Web of Science: A1994NU39000004
- 1994
  
  A NOVEL X-GENE WITH A WIDELY TRANSCRIBED Y-LINKED HOMOLOG ESCAPES X-INACTIVATION IN MOUSE AND HUMAN. HUMAN MOLECULAR GENETICS. 3:879-884.
  Full Text via DOI: 10.1093/hmg/3.6.879 Web of Science: A1994NU39000005
- 1994
  
  PHENOTYPIC-EXPRESSION OF THE FUSED (FU) GENE IN CHIMERIC MICE
  Full Text via DOI: 10.1017/S001667230003233X Web of Science: A1994PA73500003
- 1993
  
  ANALYSIS OF FUSED GENE IN CHIMERIC MICE
  Web of Science: A1993LX50500010
- 1992
  
  POLYMORPHISMS DISTINGUISHING DIFFERENT MOUSE-SPECIES AND T-HAPLOTYPES
  Full Text via DOI: 10.1017/S0016672300030652 Web of Science: A1992JR88000006
- 1991
  
  CHROMOSOME-PAIRING AND RECOMBINATION IN MICE HETEROZYGOUS FOR DIFFERENT TRANSLOCATIONS IN CHROMOSOME-16 AND CHROMOSOME-17
  Full Text via DOI: 10.1007/BF00365157 Web of Science: A1991GV35000007
- 1991
  
  FUNCTIONAL-ANALYSIS OF MUTATIONS OF MURINE CHROMOSOME-17 WITH THE USE OF TERTIARY TRISOMY. GENETICS. 127:781-788.
  Web of Science: A1991FD75300015
- 1991
  
  MEIOTIC DRIVE OF T-HAPLOTYPES - CHROMOSOME SEGREGATION IN MICE WITH TERTIARY TRISOMY
  Full Text via DOI: 10.1017/S0016672300029037 Web of Science: A1991FE83900008
- 1991
  
  SYNAPSIS AND CHIASMA DISTRIBUTION IN MICE HETEROZYGOUS FOR TRANSLOCATIONS IN CHROMOSOMES-16 AND CHROMOSOMES-17
  Web of Science: A1991FE95800008
- 1991
  
  LOW DIVERSITY OF T-HAPLOTYPES IN THE EASTERN FORM OF THE HOUSE MOUSE, MUS-MUSCULUS L. GENETICS. 127:161-168.
  Web of Science: A1991EP81100015
- 1990
  
  FUNCTIONAL-ANALYSIS OF MUTATIONS OF MURINE CHROMOSOME-17 WITH THE USE OF TERTIARY TRISOMY
  Web of Science: A1990EN01600010
- 1990
  
  MEIOTIC DRIVE OF THE T-HAPLOTYPES - CHROMOSOME SEGREGATION IN MICE WITH TERTIARY TRISOMY
  Web of Science: A1990EH76700009
- 1990
  
  TCTN MUTATION CAUSING TAILLESSNESS IN MICE HETEROZYGOUS FOR T-GENE
  Web of Science: A1990EA02300014
- 1990
  
  MEIOTIC DRIVE IN FEMALE MICE HETEROZYGOUS FOR THE HSR INSERTS ON CHROMOSOME-1
  Full Text via DOI: 10.1017/S0016672300025325 Web of Science: A1990DJ15900004
- 1990
  
  MEIOTIC DRIVE OF THE ABERRANT CHROMOSOME-1 IN THE HOUSE MOUSE
  Web of Science: A1990DB60400010
- 1990
  
  GAMETIC IMPRINTING AND THE MANIFESTATION OF THE FUSED GENE IN THE HOUSE MOUSE
  Full Text via DOI: 10.1002/dvg.1020110404 Web of Science: A1990EM98000003
- 1990
  
  Gametic imprinting and fused gene penetranse in the house mouse
- 1989
  
  Novel partial t-haplotypes of domestic mouse: characteristics of basic properties
- 1987
  
  THE INFLUENCE OF MUTATIONS ON CHROMOSOME-17 UPON THE SEGREGATION OF HOMOLOGS IN FEMALE MICE HETEROZYGOUS FOR ROBERTSONIAN TRANSLOCATIONS
  Full Text via DOI: 10.1017/S0016672300023752 Web of Science: A1987L886800010
- 1987
  
  EFFECT OF T12-HAPLOTYPE ON THE PHENOTYPIC-EXPRESSION AND INHERITANCE OF FUSED AND KINKY GENES IN THE HOUSE MOUSE
  Web of Science: A1987G754100017
- 1987
  
  LOCALIZATION OF HOUSE MOUSE GENES ON CHROMOSOMES VIA COMPARISON OF THE GENETIC-MAP AND THE CHIASMATA DISTRIBUTION
  Web of Science: A1987G754100008
- 1986
  
  Chromosome segregation in mice heterozygous for Robertsonian translocations. I. The effect of mutation in chromosome 17 on the disjunction of homologs in females
- 1986
  
  CHROMOSOME SEGREGATION IN MICE HETEROZYGOUS FOR ROBERTSONIAN TRANSLOCATIONS .2. STRUCTURAL-CHANGES IN THE HOMOLOGS AS A POSSIBLE CAUSE FOR ABNORMAL DISJUNCTION IN FEMALES
  Web of Science: A1986E731900016
- 1985
  
  Effect of some mutations of the 17th chromosome on the segregation of homologous chromosomes in the progeny of mice heterozygous for Robertsonian translocation
- 1984
  
  Effect of mutations of chromosome 17 on homolog segregation in the progeny of mice heterozygous for Robertsonian translocation
- 1983
  
  EFFECT OF HYDROCORTISONE ON THE PHENOTYPIC-EXPRESSION AND INHERITANCE OF THE FUSED GENE IN MICE. THEORETICAL AND APPLIED GENETICS. 64:275-281.
  Full Text via DOI: 10.1007/BF00274161 Web of Science: A1983QJ76300001
- A missense mutation in LRR8 of RXFP2 is associated with cryptorchidism. MAMMALIAN GENOME. 21:442-449.
  Full Text via DOI: 10.1007/s00335-010-9291-5 Web of Science: 000284184100002
- EFFECT OF THE T12 HAPLOTYPE ON PENETRANCE AND INHERITANCE OF THE FUSED AND KINKY GENES IN MICE. JOURNAL OF HEREDITY. 79:141-146.
  Full Text via DOI: 10.1093/oxfordjournals.jhered.a110481 Web of Science: A1988N999000001
Book
- 2010
  
  Relaxin and Related Peptides
- 2007
  
  Relaxin and Related Peptides: Preface. Ed. 612.
- 1967
  
  Advances in Experimental Medicine and Biology
Book Chapter
- 2007
  
  The genetics of cryptorchidism. 185-+.
  Full Text via DOI: 10.1007/978-1-59745-176-5_11 Web of Science: 000246821300011
- 2004
  
  Genomic research and progress in understanding inherited disorders in humans and other mammals. 449-476.
Conference
- 2020
  
  A Novel Human Relaxin Receptor Agonist, ML290, Attenuates Atherosclerosis- and Chronic Kidney Disease-Induced Vascular Calcification in Mice. CIRCULATION.
  Web of Science: 000607190405279
- 2020
  
  Therapeutic Effects of a Small Molecule Agonist of the Relaxin Receptor in Mice with Unilateral Ureteral Obstruction. FASEB JOURNAL.
  Full Text via DOI: 10.1096/fasebj.2020.34.s1.09260 Web of Science: 000546107900377
- 2018
  
  ML290, an Allosteric Agonist of RXFP1,Attenuates Experimental Pulmonary Hypertension. CIRCULATION.
  Web of Science: 000528619406359
- 2018
  
  ML290, an Allosteric Relaxin-RXFP1 Agonist, Attenuates Experimental Pulmonary Hypertension. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.
  Web of Science: 000449980300223
- 2017
  
  Structural modeling and identification of small molecule agonists of human relaxin family peptide receptor 1. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
  Web of Science: 000430568505930
- 2013
  
  Structural modeling of the relaxin peptide receptor and its small molecule agonists. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
  Web of Science: 000323851304270
- 2010
  
  Characterization of RXFP1 Null Mice and Role of Relaxin during Cervical Remodeling. REPRODUCTIVE SCIENCES. 77A-77A.
  Web of Science: 000275558600039
- 2010
  
  INSL3/RXFP2 AND ANDROGEN SIGNALING IN TESTICULAR DESCENT. JOURNAL OF ANDROLOGY. 48-49.
  Web of Science: 000275920400043
- 2010
  
  Hormonal Regulation of Testicular Descent. BIOLOGY OF REPRODUCTION. 55-55.
  Web of Science: 000284381300017
- 2010
  
  Ontogeny of the Relaxin Receptor (RXFP1) in the Female Mouse Reproductive Tract.. BIOLOGY OF REPRODUCTION. 130-131.
  Web of Science: 000284381300342
- 2009
  
  Suppression of Relaxin receptor RXFP1 in Prostate Cancer Cells Decreases Tumor Growth and Metastasis in vivo. CANCER RESEARCH.
  Web of Science: 000209702705445
- 2008
  
  Changes in arterial function by chronic relaxin infusion are mediated by the leucine rich repeat G coupled Lgr7 receptor.. REPRODUCTIVE SCIENCES. 217A-217A.
  Web of Science: 000253581600561
- 2004
  
  Regulation of GREAT/LGR8 signaling by beta-arrestins and G protein-coupled receptor kinases. FASEB JOURNAL. C43-C43.
  Web of Science: 000221639100198
- 2004
  
  Genetic targeting of the relaxin signaling in mice.. 193A-193A.
  Web of Science: 000220184500355
- 2004
  
  High throughput protein expression profiling of endometriosis using tissue microarrays.. 144A-144A.
  Web of Science: 000220184500215
- 2004
  
  Relaxin increases invasive potential of endometrial cancer cells in vitro.. 155A-155A.
  Web of Science: 000220184500247
- 2004
  
  Genetic targeting of relaxin signaling in mice. BIOLOGY OF REPRODUCTION. 163-163.
  Web of Science: 000222848400367
- 2003
  
  Abnormal connective tissue remodeling in mice deficient for relaxin receptor (LGR7).. AMERICAN JOURNAL OF HUMAN GENETICS. 350-350.
  Web of Science: 000185599701057
- 2003
  
  Phenotypic analysis in a behavioral test battery of three great-related mutants on different genetic backgrounds. S80-S80.
  Web of Science: 000186235700237
- 2001
  
  Cloning great - G protein-coupled receptor affecting testicular descent.. AMERICAN JOURNAL OF HUMAN GENETICS. 218-218.
  Web of Science: 000171648900217
- 2000
  
  Male sexual development in the absence of Sry.. AMERICAN JOURNAL OF HUMAN GENETICS. 1724-1724.
  Web of Science: 000088373700034
- 1999
  
  Identification and characterization of the candidate genes involved into proliferation and/or improper migration of primordial germ cells in gcd mutant mice.. AMERICAN JOURNAL OF HUMAN GENETICS. A24-A24.
  Web of Science: 000082879800119
Letter
- 1996
  
  Gene sequence and evolutionary conservation of human SMCY. 128-129.
  Full Text via DOI: 10.1038/ng1096-128 Web of Science: A1996VL44600011
Note
- 1991
  
  2 DOSES OF THE PATERNAL TME GENE DO NOT COMPENSATE THE LETHALITY OF THE THP DELETION. JOURNAL OF HEREDITY. 351-353.
  Full Text via DOI: 10.1093/oxfordjournals.jhered.a111099 Web of Science: A1991GD95400015
- 1990
  
  2 DOSES OF THE PETERNAL TME GENE DO NOT COMPENSATE THE LETHALITY OF THE THPDELETION. 2076-2078.
  Web of Science: A1990EN01600022
- 1988
  
  NEW VARIANT OF CHROMOSOME-1 IN THE HOUSE MOUSE MUS MUSCULUS. 773-+.
  Web of Science: A1988P243500020
- 1987
  
  ANALYSIS OF HYPOTHESES AND MODELING OF SELECTION FOR SUPPRESSOR AFFECTING MANIFESTATION OF FUSED GENE IN MICE. 568-570.
  Web of Science: A1987G784200024
Other Scholarly Work
- 2024
  
  Structural elucidation of RXFP2 allosteric agonist (compound-6641) binding: A computational and experimental approach. BIOPHYSICAL JOURNAL. 98A-98A.
  Web of Science: 001194120700472
- 2022
  
  RXFP2 Small Molecule Agonists: Potential Therapeutics for Osteoporosis. FASEB JOURNAL.
  Full Text via DOI: 10.1096/fasebj.2022.36.S1.R2398 Web of Science: 000878430602245
- 2021
  
  A Biased Relaxin Receptor Agonist, ML290, Attenuates Atherosclerotic Calcification in Apolipoprotein E-deficient Mice. FASEB JOURNAL.
  Full Text via DOI: 10.1096/fasebj.2021.35.S1.02926 Web of Science: 000669893102336
- 2019
  
  Development of Adipose Fibrosis and Dysfunction in Aged Rxfp1-/- Mice
  Full Text via DOI: 10.2337/db19-1769-P Web of Science: 000501366904166
- 2017
  
  Relaxin-like peptides in male reproduction - a human perspective (vol 174, pg 990, 2017). BRITISH JOURNAL OF PHARMACOLOGY. 4836-4836.
  Web of Science: 000427839000025
- 2015
  
  Long-Lasting Consequences of Testosterone Exposure. ENDOCRINOLOGY. 3488-3489.
  Full Text via DOI: 10.1210/en.2015-1719 Web of Science: 000362235300014
- 2014
  
  Vascular reactivity is altered in mice with a conditional knockout of relaxin receptor in endothelial cells. FASEB JOURNAL.
  Web of Science: 000346646703148
- 2005
  
  Editorial: Cryptorchidism - An estrogen spoil?. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 4975-4977.
  Full Text via DOI: 10.1210/jc.2005-1290 Web of Science: 000231068500081
- 2004
  
  Protein expression profiling of endometriosis: validation of 2-mm tissue microarrays. FERTILITY AND STERILITY. 1681-1683.
  Full Text via DOI: 10.1016/j.fertnstert.2004.06.044 Web of Science: 000225802300034
- 2003
  
  Molecular profiling of endometriosis using tissue microarrays: Disease correlation with increased expression of estrogen receptor-alpha (ER-alpha) and decreased expression of progesterone receptor (PR).. FERTILITY AND STERILITY. S33-S33.
  Web of Science: 000185672400088
- 2002
  
  Mutation analysis of the GREAT (G Protein-Coupled Receptor Affecting Testis Descent) gene in cryptorchid patients.. FERTILITY AND STERILITY. S96-S96.
  Full Text via DOI: 10.1016/S0015-0282(02)03633-6 Web of Science: 000178239400253
- 1998
  
  Erratum: A murine TSPY (Chromosome Research (1998) 6 (35-40)). CHROMOSOME RESEARCH. 241.
Review
- 2022
  
  Expression patterns and the roles of phosphatidylinositol phosphatases in testis^†. BIOLOGY OF REPRODUCTION. 902-915.
  Full Text via DOI: 10.1093/biolre/ioac132 Web of Science: 000838505900001
- 2020
  
  Diverse functions of insulin-like 3 peptide. JOURNAL OF ENDOCRINOLOGY. R1-R12.
  Full Text via DOI: 10.1530/JOE-20-0168 Web of Science: 000574819900001
- 2017
  
  Relaxin-like peptides in male reproduction - a human perspective. BRITISH JOURNAL OF PHARMACOLOGY. 990-1001.
  Full Text via DOI: 10.1111/bph.13689 Web of Science: 000400597900007
- 2017
  
  Synthetic non-peptide low molecular weight agonists of the relaxin receptor 1. BRITISH JOURNAL OF PHARMACOLOGY. 977-989.
  Full Text via DOI: 10.1111/bph.13656 Web of Science: 000400597900006
- 2013
  
  Testicular cancer and cryptorchidism
  Full Text via DOI: 10.3389/fendo.2013.00032
- 2010
  
  Discovery, optimization, and biological activity of the first potent and selective small-molecule agonist series of human relaxin receptor 1 (RXFP1)
- 2005
  
  Mouse mutants of relaxin, insulin-like 3 peptide and their receptors. 411-419.
  Full Text via DOI: 10.2174/156801305774322420
- 2004
  
  Insulin-like 3 signalling in testicular descent. 257-265.
  Full Text via DOI: 10.1111/j.1365-2605.2004.00481.x Web of Science: 000223997300002
- 2002
  
  Gene expression profiling in RAS oncogene-transformed cell lines and in solid tumors using subtractive suppression hybridization and cDNA arrays. 63-82.
  Full Text via DOI: 10.1016/S0065-2571(01)00024-3 Web of Science: 000179396600005

principal investigator on

Engineering a long-acting relaxin agonist to treat liver fibrosis awarded by National Institutes of Health 2021 - 2023
Relaxin receptor agonists for treatment of liver fibrosis awarded by Diabetes & Digestive & Kidney Diseases 2017 - 2023
Small molecule agonists of insulin-like3 receptor for osteoporosis treatment awarded by Arthritis & Musculoskeletal & Skin Disea 2016 - 2020
Small molecule relaxin receptor agonists in treatment of uterine fibroids awarded by Bayer Pharmaceuticals 2017 - 2018
8th International Conference on Relaxin and Related Peptides 2018 awarded by Bristol-Myers Squibb 2017 - 2018
Relaxin receptor agonists in treatment of pulmonary hypertension awarded by NatlCtr Advancing Translational Sciences 2016 - 2017
Small molecule antagonists of relaxin receptor awarded by National Cancer Institute 2013 - 2017
Small molecule agonists of relaxin receptor awarded by Bristol-Myers Squibb 2014 - 2015
Vascular effects of relaxin receptor agonists awarded by Florida Department of Health 2013 - 2014
Small Molecule agonists of relaxin receptor awarded by FIU Office of Research and Economic Deve 2012 - 2013
Mechanisms of Renal Vasolidation by Relaxin awarded by National Heart, Lung, & Blood Institute 2009 - 2013
Role of Y Chromosomal Genes in Male Fertility. awarded by Child Health and Human Development 2009 - 2011
Small molecule agonists of the relaxin receptor awarded by National Institute of Mental Health 2009 - 2011
Genetic Basis of Testicular Descent. awarded by Child Health and Human Development 2009 - 2011

co-principal investigator on

Grant
- Targeting breast cancer microenvironment with small molecule agonist of relaxin receptor awarded by National Cancer Institute 2023 - 2025
- A Novel Small Molecule Therapy for Late-Stage Atherosclerosis awarded by Florida Heart Research Foundation Inc 2021 - 2024
- Androgen Regulation of Novel Tumor Suppressor in Male and Female Breast Cancer awarded by U.S. Department of Defense 2010 - 2011

ORCID iD

https://orcid.org/0000-0001-6587-6845 (confirmed)

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