Journal of Biological Chemistry

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Journal of Biological Chemistry Journal

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Ebola Virus VP40 C-terminal Lysine Residue Mediates Lipid Interactions and Dimer-Dimer Interactions.. 113709. 2026
Variants of the Ebola virus matrix protein VP40 have differential effects on oligomerization and plasma membrane interactions. 301. 2025
Restricted human CD45 isoglycoforms serve as functional E-selectin ligands and delineate hematopoietic maturity. 301. 2025
Hepatic glutamic-oxaloacetic transaminase promotes mitochondrial respiration energized at complex II and alters whole body metabolism. 301. 2025
Novel mechanism of cyclic nucleotide crosstalk mediated by PKG-dependent proteasomal degradation of the Hsp90 client protein phosphodiesterase 3A. 300. 2024
Minor electrostatic changes robustly increase VP40 membrane binding, assembly, and budding of Ebola virus matrix protein derived virus-like particles. 300. 2024
Plasmodium parasitophorous vacuole membrane protein Pfs16 promotes malaria transmission by silencing mosquito immunity. 299. 2023
Nitration of protein kinase G-Iα modulates cyclic nucleotide crosstalk via phosphodiesterase 3A: Implications for acute lung injury. 297. 2021
Modulation of glycosyltransferase ST6Gal-I in gastric cancer-derived organoids disrupts homeostatic epithelial cell turnover. 295:14153-14163. 2020
Noncovalent interactions dominate dynamic heme distortion in cytochrome P450 4B1. 293:11433-11446. 2018
Distinct human (1,3)-fucosyltransferases drive Lewis-X/sialyl Lewis-X assembly in human cells. 293:7300-7314. 2018
Membrane-embedded substrate recognition by cytochrome P450 3A4. 293:4037-4046. 2018
A cationic, C-terminal patch and structural rearrangements in Ebola virus matrix VP40 protein control its interactions with phosphatidylserine. 293:3335-3349. 2018
Caveolin-1 promotes the tumor suppressor properties of oncogene-induced cellular senescence. 293:1794-1809. 2018
ST6Gal-I sialyltransferase promotes chemoresistance in pancreatic ductal adenocarcinoma by abrogating gemcitabine-mediated DNA damage. 293:984-994. 2018
Transient and dynamic DNA supercoiling potently stimulates the leu-500 promoter in Escherichia coli. 292:14566-14575. 2017
Disruption of mitochondrial electron transport chain function potentiates the pro-apoptotic effects of MAPK inhibition. 292:11727-11739. 2017
The fibrinogen-like domain of FREP1 protein is a broad-spectrum malaria transmission-blocking vaccine antigen. 292:11960-11969. 2017
Detection of lipid-induced structural changes of the Marburg virus matrix protein VP40 using hydrogen/deuterium exchange-mass spectrometry. 292:6108-6122. 2017
Role of Sphingosine Kinase 1 and S1P Transporter Spns2 in HGF-mediated Lamellipodia Formation in Lung Endothelium. 291:27187-27203. 2016
A Method for Multiplexed Measurement of Mitochondrial Pyruvate Carrier Activity. 291:7409-7417. 2016
Exosomes from HIV-1-infected Cells Stimulate Production of Pro-inflammatory Cytokines through Trans-activating Response (TAR) RNA. 291:1251-1266. 2016
Nitration of Hsp90 on Tyrosine 33 Regulates Mitochondrial Metabolism. 290:19055-19066. 2015
Anopheles Midgut FREP1 Mediates Plasmodium Invasion. 290:16490-16501. 2015
COPS5 Protein Overexpression Increases Amyloid Plaque Burden, Decreases Spinophilin-immunoreactive Puncta, and Exacerbates Learning and Memory Deficits in the Mouse Brain. 290:9299-9309. 2015
Paraoxonase 2 Serves a Proapopotic Function in Mouse and Human Cells in Response to the Pseudomonas aeruginosa Quorum-sensing Molecule N-(3-Oxododecanoyl)-homoserine Lactone. 290:7247-7258. 2015
Evidence for an Elevated Aspartate pK_a in the Active Site of Human Aromatase. 290:1186-1196. 2015
Novel Peptide for Attenuation of Hyperoxia-induced Disruption of Lung Endothelial Barrier and Pulmonary Edema via Modulating Peroxynitrite Formation. 289:33355-33363. 2014
Modulation of the Voltage-gated Potassium Channel (Kv4.3) and the Auxiliary Protein (KChIP3) Interactions by the Current Activator NS5806. 289:32201-32213. 2014
B Cell Lymphoma-2 (BCL-2) Homology Domain 3 (BH3) Mimetics Demonstrate Differential Activities Dependent upon the Functional Repertoire of Pro-and Anti-apoptotic BCL-2 Family Proteins. 289:26481-26491. 2014
Nitration of Tyrosine 247 Inhibits Protein Kinase G-1α Activity by Attenuating Cyclic Guanosine Monophosphate Binding. 289:7948-7961. 2014
Lipopolysaccharide- induced Lung Injury Involves the Nitration- mediated Activation of RhoA*. 289:4710-4722. 2014
COPS5 (Jab1) Protein Increases β Site Processing of Amyloid Precursor Protein and Amyloid β Peptide Generation by Stabilizing RanBP9 Protein Levels. 288:26668-26677. 2013
Asymmetric Dimethylarginine Induces Endothelial Nitric-oxide Synthase Mitochondrial Redistribution through the Nitration-mediated Activation of Akt1. 288:6212-6226. 2013
Blocking c-Jun N-terminal Kinase (JNK) Translocation to the Mitochondria Prevents 6-Hydroxydopamine-induced Toxicity in Vitro and in Vivo. 288:1079-1087. 2013
Cigarette Smoke Induces MUC5AC Protein Expression through the Activation of Sp1. 287:27948-27958. 2012
Nitroalkenes Confer Acute Cardioprotection via Adenine Nucleotide Translocase 1. 287:3573-3580. 2012
Efflux Permease CgAcr3-1 of Corynebacterium glutamicum Is an Arsenite-specific Antiporter. 287:723-735. 2012
Peracetylated 4-Fluoro-glucosamine Reduces the Content and Repertoire of N- and O-Glycans without Direct Incorporation. 286:21717-21731. 2011
The Strictly Conserved Arg-321 Residue in the Active Site of Escherichia coli Topoisomerase I Plays a Critical Role in DNA Rejoining. 286:18673-18680. 2011
Inactivation and Reactivation of the Mitochondrial α-Ketoglutarate Dehydrogenase Complex. 286:17640-17648. 2011
Mitochondrial c-Jun N-terminal Kinase (JNK) Signaling Initiates Physiological Changes Resulting in Amplification of Reactive Oxygen Species Generation. 286. 2011
BH3 Domains other than Bim and Bid Can Directly Activate Bax/Bak. 286:491-501. 2011
Inhibitory Phosphorylation of GSK-3 by CaMKII Couples Depolarization to Neuronal Survival. 285:41122-41134. 2010
Cu, Zn-Superoxide Dismutase Increases Toxicity of Mutant and Zinc-deficient Superoxide Dismutase by Enhancing Protein Stability. 285:33885-33897. 2010
A Novel Function of Sphingosine Kinase 1 Suppression of JNK Activity in Preventing Inflammation and Injury. 285:15848-15857. 2010
Perturbations in Mitochondrial Dynamics Induced by Human Mutant PINK1 Can Be Rescued by the Mitochondrial Division Inhibitor mdivi-1. 285:11740-11752. 2010
Control of Steroid 21-oic Acid Synthesis by Peroxisome Proliferator-activated Receptor α and Role of the Hypothalamic-Pituitary-Adrenal Axis. 285:7670-7685. 2010
Coordination between Polymerase β and FEN1 Can Modulate CAG Repeat Expansion. 284:28352-28366. 2009
Properties of Arsenite Efflux Permeases (Acr3) from Alkaliphilus metalliredigens and Corynebacterium glutamicum. 284:19887-19895. 2009
Regulation of Heparan Sulfate and Chondroitin Sulfate Glycosaminoglycan Biosynthesis by 4-Fluoro-glucosamine in Murine Airway Smooth Muscle Cells. 284:16832-16839. 2009
Novel Role of RanBP9 in BACE1 Processing of Amyloid Precursor Protein and Amyloid β Peptide Generation. 284:11863-11872. 2009
Caveolin-1 Expression Is Required for the Development of Pulmonary Emphysema through Activation of the ATM-p53-p21 Pathway. 284:5462-5466. 2009
Low Intensity Shear Stress Increases Endothelial ELR⁺ CXC Chemokine Production via a Focal Adhesion Kinase-p38β MAPK-NF-κB Pathway. 284:5945-5955. 2009
Protein Kinase A-mediated Gating of Neuregulin-dependent ErbB2-ErbB3 Activation Underlies the Synergistic Action of cAMP on Schwann Cell Proliferation. 283:34087-34100. 2008
Evolution of metal(loid) binding sites in transcriptional regulators. 283:25706-25714. 2008
L-selectin-mediated lymphocyte-cancer cell interactions under low fluid shear conditions. 283:15816-15824. 2008
Assembly of heterohexameric trypanosome hexokinases reveals that hexokinase 2 is a regulable enzyme. 283:14963-14970. 2008
The hominoid-specific oncogene TBC1D3 activates ras and modulates epidermal growth factor receptor signaling and trafficking. 283:13233-13242. 2008
Convergent evolution of a new arsenic binding site in the ArsR/SmtB family of metalloregulators. 282:34346-34355. 2007
ArsD residues Cys¹², Cys¹³, and Cys¹⁸ form an As(III)-binding site required for arsenic metallochaperone activity. 282:16783-16791. 2007
Coordination of steps in single-nucleotide base excision repair mediated by apurinic/apyrimidinic endonuclease 1 and DNA polymerase β. 282:13532-13541. 2007
HCELL is the major E- and L-selectin ligand expressed on LS174T colon carcinoma cells. 281:13899-13905. 2006
Cys-113 and Cys-422 form a high affinity metalloid binding site in the ArsA ATPase. 281:9925-9934. 2006
Hypothyroid phenotype is contributed by mitochondrial complex I inactivation due to translocated neuronal nitric-oxide synthase. 281:4779-4786. 2006
Bacterial cell killing mediated by topoisomerase I DNA cleavage activity. 280:38489-38495. 2005
Crystal structure of Kunitz domain 1 (KD1) of tissue factor pathway inhibitor-2 in complex with trypsin - Implications for KD1 specificity of inhibition. 280:27832-27838. 2005
Inhibition of protein-tyrosine phosphatases by mild oxidative stresses is dependent on S-nitrosylation. 280:14453-14461. 2005
Nonequivalence of the nucleotide binding domains of the ArsA ATPase. 280:9921-9926. 2005
DNA polymerase β and flap endonuclease 1 enzymatic specificities sustain DNA synthesis for long patch base excision repair. 280:3665-3674. 2005
The tryptophan-rich motifs of the thrombospondin type 1 repeats bind VLAL motifs in the latent transforming growth factor-β complex. 279:47633-47642. 2004
Protein kinase C θ inhibits insulin signaling by phosphorylating IRS1 at Ser¹¹⁰¹. 279:45304-45307. 2004
Site-directed mutagenesis of residues involved in G strand DNA binding by Escherichia coli DNA topoisomerase I. 279:39207-39213. 2004
Leishmania major LmACR2 is a pentavalent antimony reductase that confers sensitivity to the drug Pentostam. 279:37445-37451. 2004
Molecular interactions that confer latency to transforming growth factor-β. 279:38032-38039. 2004
Drug uptake and modulation of drug resistance in Leishmania by an aquaglyceroporin. 279:31010-31017. 2004
As(III) and Sb(III) uptake by G1pF and efflux by ArsB in Escherichia coli. 279:18334-18341. 2004
Arsenic trioxide uptake by hexose permeases in Saccharomyces cerevisiae. 279:17312-17318. 2004
Structure-function analysis of the reactive site in the first Kunitz-type domain of human tissue factor pathway inhibitor-2. 279:17500-17507. 2004
5-aza-2′-deoxycytidine activates the p53/p21^Waf1/Cip1 pathway to inhibit cell proliferation. 279:15161-15166. 2004
Flexibility at Gly-194 is required for DNA cleavage and relaxation activity of Escherichia coli DNA topoisomerase I. 279:8648-8654. 2004
Direct interaction between Escherichia coli RNA polymerase and the zinc ribbon domains of DNA topoisomerase I. 278:30705-30710. 2003
Analysis of human flap endonuclease 1 mutants reveals a mechanism to prevent triplet repeat expansion. 278:13728-13739. 2003
Molecular cloning and characterization of spurt, a human novel gene that is retinoic acid-inducible and encodes a secretory protein specific in upper respiratory tracts. 278:1165-1173. 2003
Biochemical characterization of CopA, the Escherichia coli Cu(I)-translocating P-type ATPase. 277:46987-46992. 2002
1,25-dihydroxyvitamin D down-regulates cell membrane growth- and nuclear growth-promoting signals by the epidermal growth factor receptor. 277:38965-38971. 2002
Identification and characterization of a novel rat ov-serpin family member, trespin. 277:26412-26421. 2002
Unisite and multisite catalysis in the ArsA ATPase. 277:23815-23820. 2002
A single nucleotide polymorphism in the matrix metalloproteinase-1 (MMP-1) promoter influences amnion cell MMP-1 expression and risk for preterm premature rupture of the fetal membranes. 277:6296-6302. 2002
Differential L-selectin binding activities of human hematopoietic cell L-selectin ligands, HCELL and PSGL-1. 276:47623-47631. 2001
The phosphatase C(X)₅R motif is required for catalytic activity of the Saccharomyces cerevisiae Acr2p arsenate reductase. 276:34738-34742. 2001
Conformational changes in four regions of the Escherichia coli ArsA ATPase link ATP hydrolysis to ion translocation. 276:30414-30422. 2001
Bcl-xL, blocks transforming growth factor-β1-induced apoptosis by inhibiting cytochrome c release and not by directly antagonizing Apaf-1-dependent caspase activation in prostate epithelial cells. 276:26614-26621. 2001
Role of cysteinyl residues in sensing Pb(II), Cd(II), and Zn(II) by the plasmid pI258 CadC repressor. 276:14955-14960. 2001
A kinetic model for the action of a resistance efflux pump. 276:6378-6391. 2001
A novel membrane-anchored rab5 interacting protein required for homotypic endosome fusion. 275:24661-24669. 2000
Purification and characterization of Acr2p, the Saccharomyces cerevisiae arsenate reductase. 275:21149-21157. 2000
The acidic triad conserved in type IA DNA topoisomerases is required for binding of Mg(II) and subsequent conformational change. 275:5318-5322. 2000
The ATPase mechanism of ArsA, the catalytic subunit of the arsenite pump. 274:16153-16161. 1999
Binding of xanthine oxidase to vascular endothelium - Kinetic characterization and oxidative impairment of nitric oxide-dependent signaling. 274:4985-4994. 1999
Pb(II)-translocating P-type ATPases. 273:32614-32617. 1998
A novel mechanism-based inhibitor (6′-bromo-5′,6′-didehydro-6′-deoxy-6′-fluorohomoadenosine) that covalently modifies human placental S-adenosylhomocysteine hydrolase. 273:18191-18197. 1998
CONSTRUCTION OF A CHIMERIC ARSA-ARSB PROTEIN FOR OVEREXPRESSION OF THE OXYANION-TRANSLOCATING ATPASE. 267:25768-25775. 1992
ZINC(II) COORDINATION IN ESCHERICHIA-COLI DNA TOPOISOMERASE-I IS REQUIRED FOR CLEAVABLE COMPLEX-FORMATION WITH DNA. 266:14317-14320. 1991
SUBSTRATE-INDUCED DIMERIZATION OF THE ARSA PROTEIN, THE CATALYTIC COMPONENT OF AN ANION-TRANSLOCATING ATPASE. 266:2327-2332. 1991
MUTAGENESIS OF A NUCLEOTIDE-BINDING SITE OF AN ANION-TRANSLOCATING ATPASE. 265:7832-7836. 1990
MOLECULAR CHARACTERIZATION OF AN ANION PUMP - THE ARSB PROTEIN IS THE MEMBRANE ANCHOR FOR THE ARSA PROTEIN. 265:190-194. 1990
CHARACTERIZATION OF THE CATALYTIC SUBUNIT OF AN ANION PUMP. 264:17349-17354. 1989
MAINTENANCE OF INTRACELLULAR CALCIUM IN ESCHERICHIA-COLI. 262:12570-12574. 1987
RECONSTITUTION OF ATP-DEPENDENT CALCIUM-TRANSPORT FROM STREPTOCOCCI. 261:5596-5600. 1986
NUCLEOTIDE-SEQUENCE OF THE STRUCTURAL GENES FOR AN ANION PUMP - THE PLASMID-ENCODED ARSENICAL RESISTANCE OPERON. 261:5030-5038. 1986
UNCOUPLING OF THE DNA BREAKING AND REJOINING STEPS OF ESCHERICHIA-COLI TYPE-I DNA TOPOISOMERASE - DEMONSTRATION OF AN ACTIVE COVALENT PROTEIN-DNA COMPLEX. 261:931-935. 1986
CATION PROTON ANTIPORT SYSTEMS IN ESCHERICHIA-COLI - SOLUBILIZATION AND RECONSTITUTION OF DELTA-PH-DRIVEN SODIUM PROTON AND CALCIUM PROTON ANTIPORTERS. 261:678-683. 1986
CALCIUM EFFLUX FROM ESCHERICHIA-COLI - EVIDENCE FOR 2 SYSTEMS. 259:6142-6146. 1984
PHYLOGENETIC CONSERVATION OF A CLASS-III MAJOR HISTOCOMPATIBILITY COMPLEX ANTIGEN, FACTOR-B - ISOLATION AND NUCLEOTIDE SEQUENCING OF MOUSE FACTOR-B CDNA CLONES. 258:4693-4697. 1983
CATION-PROTON ANTIPORT SYSTEMS IN ESCHERICHIA-COLI - PROPERTIES OF THE POTASSIUM-PROTON ANTIPORTER. 255:39-44. 1980
COVALENT BONDS BETWEEN PROTEIN AND DNA - FORMATION OF PHOSPHOTYROSINE LINKAGE BETWEEN CERTAIN DNA TOPOISOMERASES AND DNA. 255:5560-5565. 1980
CATION-PROTON ANTIPORT SYSTEMS IN ESCHERICHIA-COLI - PROPERTIES OF THE CALCIUM-PROTON ANTIPORTER. 254:1957-1963. 1979
BASIC AMINO-ACID TRANSPORT IN ESCHERICHIA-COLI .2. PURIFICATION AND PROPERTIES OF AN ARGININE-SPECIFIC BINDING PROTEIN. 248:1211-1218. 1973
ApoC-III is a novel inducer of calcification in human aortic valves. 296.
CRAC channel opening is determined by a series of Orai1 gating checkpoints in the transmembrane and cytosolic regions. 296.
Glycosyltransferase ST6Gal-I promotes the epithelial to mesenchymal transition in pancreatic cancer cells. 296.
Lipid-specific oligomerization of the Marburg virus matrix protein VP40 is regulated by two distinct interfaces for virion assembly. 296.
"It's completely erasure": A Qualitative Exploration of Experiences of Transgender, Nonbinary, Gender Nonconforming, and Questioning Students in Biology Courses 2023
RNA synthesis by a translesion DNA polymerase mediates RNA base damage repair 2023
ESCHERICHIA-COLI DNA TOPOISOMERASE-I IS A ZINC METALLOPROTEIN WITH 3 REPETITIVE ZINC-BINDING DOMAINS 1988
MOLECULAR CHARACTERIZATION OF AN ANION PUMP - THE ARSA GENE-PRODUCT IS AN ARSENITE(ANTIMONATE)-STIMULATED ATPASE 1988
CATION-PROTON ANTIPORT SYSTEMS IN ESCHERICHIA-COLI - ABSENCE OF POTASSIUM-PROTON ANTIPORTER ACTIVITY IN A PH-SENSITIVE MUTANT 1980
Prevention of peroxynitrite-induced apoptosis of motor neurons and PC12 cells by tyrosine-containing peptides 2007
Mammalian zinc transport, trafficking, and signals 2006
Escherichia coli soft metal ion-translocating ATPases 2000
A Novel High Throughput Screening (HTS) Method to Discover Bacterial DNA Gyrase Poisons 2025
In vitro synthesizing unmodified supercoiled circular DNA molecules 2025
RNA-seq Analysis of Serum Starvation in H. pylori 2025
Identification of flexible hinge region residues in bacterial topoisomerase IA 2024
Revealing the nucleic acid interactions of human topoisomerase 3 beta, a unique dualacting topoisomerase, and discovering its inhibitors 2024
Enrichment and Analysis of Head and Neck Cancer Mucin-Domain Glycoproteins Reveals the Presence of Tumor-Derived Immunoglobulin A 2023
PSI relieves the pressure of membrane fusion 2020
Nitroalkenes confer acute cardioprotection via adenine nucleotide translocase 1 (vol 287, pg 3573, 2012) 2015

Electronic International Standard Serial Number (EISSN)

1083-351X