FIU Discovery

Integrative Proteomic and Phosphoproteomic Analyses of Hypoxia-Treated Pulmonary Artery Smooth Muscle Cells.  Proteomes.  10.

Artemisinin and Its Derivate Alleviate Pulmonary Hypertension and Vasoconstriction in Rodent Models.  Oxidative Medicine and Cellular Longevity.  2022.

Sodium tanshinone IIA sulfonate enhances the BMP9-BMPR2-Smad1/5/9 signaling pathway in rat pulmonary microvascular endothelial cells and human embryonic stem cell–derived endothelial cells.  Biochemical Pharmacology.  199.

Gut Microbial Metabolite Trimethylamine N-Oxide Aggravates Pulmonary Hypertension.  American Journal of Respiratory Cell and Molecular Biology.  66:452-460.

Established pulmonary hypertension in rats was reversed by a combination of a HIF-2α antagonist and a p53 agonist.  British Journal of Pharmacology.  179:1065-1081.

Abstract 12319: 16alpha-Hydroxyestrone Downregulates SOX17 During the Development of Pulmonary Arterial Hypertension.  Circulation.  144:a12319-a12319.

Melatonin Promotes the Therapeutic Effect of Mesenchymal Stem Cells on Type 2 Diabetes Mellitus by Regulating TGF-β Pathway.  Frontiers in Cell and Developmental Biology.  9.

Upregulation of Piezo1 (Piezo Type Mechanosensitive Ion Channel Component 1) Enhances the Intracellular Free Calcium in Pulmonary Arterial Smooth Muscle Cells From Idiopathic Pulmonary Arterial Hypertension Patients.  Hypertension.  77:1974-1989.

IL-18 mediates sickle cell cardiomyopathy and ventricular arrhythmias.  Blood.  137:1208-1218.

Design and Comprehensive Characterization of Tetramethylpyrazine (TMP) for Targeted Lung Delivery as Inhalation Aerosols in Pulmonary Hypertension (PH): In Vitro Human Lung Cell Culture and In Vivo Efficacy.  Antioxidants.  10.

A TOR2A Gene Product: Salusin-β Contributes to Attenuated Vasodilatation of Spontaneously Hypertensive Rats.  Cardiovascular Drugs and Therapy.  35:125-139.

Artemisinin improves acetylcholine-induced vasodilatation in rats with primary hypertension.  Drug Design, Development and Therapy.  15:4489-4502.

Mitomycin C induces pulmonary vascular endothelial-to-mesenchymal transition and pulmonary veno-occlusive disease via Smad3-dependent pathway in rats.  British Journal of Pharmacology.  178:217-235.

PDGF/MEK/ERK axis represses Ca2+clearance via decreasing the abundance of plasma membrane Ca2+pump PMCA4 in pulmonary arterial smooth muscle cells.  American Journal of Physiology - Cell Physiology.  320:C66-C79.

Altered Airway Microbiota Composition in Patients With Pulmonary Hypertension.  Hypertension.  76:1589-1599.

A novel rat model of pulmonary hypertension induced by mono treatment with SU5416.  Hypertension Research.  43:754-764.

Direct extracellular NAMPT involvement in pulmonary hypertension and vascular remodeling transcriptional regulation by SOX and HIF-2a.  American Journal of Respiratory Cell and Molecular Biology.  63:92-103.

Endothelial platelet-derived growth factor-mediated activation of smooth muscle platelet-derived growth factor receptors in pulmonary arterial hypertension.  Pulmonary Circulation.  10.

Pulmonary vessel casting in a rat model of monocrotaline-mediated pulmonary hypertension.  Pulmonary Circulation.  10.

Genetic Admixture and Survival in Diverse Populations with Pulmonary Arterial Hypertension.  American Journal of Respiratory and Critical Care Medicine.  201:1407-1415.

Predicting poor outcomes and the need for surgical treatment in neonates with meconium peritonitis.  Prenatal Diagnosis.  40:351-357.

Transcriptomic profiles in pulmonary arterial hypertension associate with disease severity and identify novel candidate genes.  Pulmonary Circulation.  10.

Transplantation of Mesenchymal Stem Cells Attenuates Pulmonary Hypertension by Normalizing the Endothelial-to-Mesenchymal Transition.  American Journal of Respiratory Cell and Molecular Biology.  62:49-60.

Effects of Angiotensin-(1-7) and Angiotensin II on Acetylcholine-Induced Vascular Relaxation in Spontaneously Hypertensive Rats.  Oxidative Medicine and Cellular Longevity.  2019.

ALDH2 (Aldehyde Dehydrogenase 2) Protects Against Hypoxia-Induced Pulmonary Hypertension.  Arteriosclerosis, Thrombosis and Vascular Biology.  39:2303-2319.

Angiotensin-(1-7) induced vascular relaxation in spontaneously hypertensive rats.  Nitric Oxide - Biology and Chemistry.  88:1-9.

Echocardiographic assessment of right ventricular function in experimental pulmonary hypertension.  Pulmonary Circulation.  9.

Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis.  The Lancet Respiratory Medicine.  7:227-238.

Establishment and evaluation of chronic obstructive pulmonary disease model by chronic exposure to motor vehicle exhaust combined with lipopolysaccharide instillation.  Experimental Physiology.  103:1532-1542.

Smooth muscle cell-specific FoxM1 controls hypoxia-induced pulmonary hypertension.  Cellular Signalling.  51:119-129.

Circulating transcriptome as a signature for the diagnosis of pulmonary arterial hypertension..  The FASEB Journal.  32:586.4-586.4.

Endothelial‐dependent activation of smooth muscle PDGF Receptors enhances PASMC proliferation in IPAH.  The FASEB Journal.  32:lb444-lb444.

Potential Diagnostic Power of Blood Circular RNA Expression in Active Pulmonary Tuberculosis.  EBioMedicine.  27:18-26.

Comparison and evaluation of two different methods to establish the cigarette smoke exposure mouse model of COPD.  Scientific Reports.  7.

Expression profile of mitochondrial voltage-dependent anion channel-1 (VDAC1) influenced genes is associated with pulmonary hypertension.  Korean Journal of Physiology and Pharmacology.  21:353-360.

Nicotinamide Phosphoribosyltransferase Promotes Pulmonary Vascular Remodeling and Is a Therapeutic Target in Pulmonary Arterial Hypertension.  Circulation.  135:1532-+.

Angiotensin-(1-7) in Paraventricular Nucleus Contributes to the Enhanced Cardiac Sympathetic Afferent Reflex and Sympathetic Activity in Chronic Heart Failure Rats.  Cellular Physiology and Biochemistry.  42:2523-2539.

Orai1, 2, 3 and. STIM1 promote store-operated calcium entry in pulmonary arterial smooth muscle cells.  Cell Death Discovery.  3.

miR-17/20 Controls Prolyl Hydroxylase 2 (PHD2)/Hypoxia-Inducible Factor 1 (HIF1) to Regulate Pulmonary Artery Smooth Muscle Cell Proliferation.  Journal of the American Heart Association.  5.

Bortezomib alleviates experimental pulmonary hypertension by regulating intracellular calcium homeostasis in PASMCs.  American Journal of Physiology - Cell Physiology.  311:C482-C497.

Kinematic analysis and experiment of planetary five-bar planting mechanism for zero-speed transplanting on mulch film.  International Journal of Agricultural and Biological Engineering.  9:84-91.

Sodium tanshinone IIA sulfonate inhibits hypoxia-induced enhancement of SOCE in pulmonary arterial smooth muscle cells via the PKG-PPAR-γ signaling axis.  American Journal of Physiology - Cell Physiology.  311:C136-C149.

Inhibition of Nicotinamide Phosphoribosyltransferase (NAMPT) Attenuates Experimental Pulmonary Hypertension.  Journal of Investigative Medicine.  64:912-913.

Role of Endothelial Hypoxia-Inducible Factors in Hypoxia-Induced Pulmonary Vasoconstriciton.  Journal of Investigative Medicine.  64:974-974.

Abstract 19126: Endothelial-specific Deletion of Prolyl Hydroxylase Domain Protein 2 (PHD2) Results in Severe Pulmonary Hypertension in Mice by Enhancing the HIF2alpha Signaling Pathway.  Circulation.  132.

Notch Activation of Ca²⁺ Signaling in the Development of Hypoxic Pulmonary Vasoconstriction and Pulmonary Hypertension.  American Journal of Respiratory Cell and Molecular Biology.  53:355-367.

Upregulated expression of STIM2, TRPC6, and Orai2 contributes to the transition of pulmonary arterial smooth muscle cells from a contractile to proliferative phenotype.  American Journal of Physiology - Cell Physiology.  308:C581-C593.

Loss of MicroRNA-17∼92 in Smooth Muscle Cells Attenuates Experimental Pulmonary Hypertension via Induction of PDZ and LIM Domain 5.  American Journal of Respiratory and Critical Care Medicine.  191:678-692.

HIF2α signaling inhibits adherens junctional disruption in acute lung injury.  Journal of Clinical Investigation.  125:652-664.

Deficiency of Akt1, but not Akt2, attenuates the development of pulmonary hypertension.  American Journal of Physiology - Lung Cellular and Molecular Physiology.  308:L208-L220.

Abstract 13284: A Novel Formulation of Vasoactive Intestinal Peptide Attenuates both Acute Hypoxic Pulmonary Vasoconstriction and the Development of Pulmonary Hypertension.  Circulation.  130.

The Sphingosine Kinase 1/Sphingosine-1-Phosphate Pathway in Pulmonary Arterial Hypertension.  American Journal of Respiratory and Critical Care Medicine.  190:1032-1043.

Flow shear stress enhances intracellular Ca²⁺ signaling in pulmonary artery smooth muscle cells from patients with pulmonary arterial hypertension.  American Journal of Physiology - Cell Physiology.  307:C373-C383.

MiR‐17~92 promotes hypoxia‐induced pulmonary hypertension by regulating proliferation and contraction of pulmonary arterial smooth muscle cells (LB779).  The FASEB Journal.  28.

Shear stress enhance intracellular Ca2+ in PASMC from patients with idiopathic pulmonary arterial hypertension (1090.13).  The FASEB Journal.  28.

The crucial role of calcium sensing receptor for hypoxia‐induced pulmonary arterial hypertension in mice (889.2).  The FASEB Journal.  28.

Upregulated Copper Transporters in Hypoxia-Induced Pulmonary Hypertension.  PLoS ONE.  9.

Adenosine Monophosphate-Activated Protein Kinase Is Required for Pulmonary Artery Smooth Muscle Cell Survival and the Development of Hypoxic Pulmonary Hypertension.  American Journal of Respiratory Cell and Molecular Biology.  49:609-618.

Chronic hypoxia selectively enhances L- and T-type voltage-dependent Ca²⁺ channel activity in pulmonary artery by upregulating Ca_v1.2 and Ca_v3.2.  American Journal of Physiology - Lung Cellular and Molecular Physiology.  305:L154-L164.

Functional characterization of voltage-dependent Ca²⁺ channels in mouse pulmonary arterial smooth muscle cells: divergent effect of ROS.  American Journal of Physiology - Cell Physiology.  304:C1042-C1052.

Labeling of Hematopoietic Stem Cells by Tat Peptide Conjugated Quantum Dots for Cell Tracking in Mouse Body.  Journal of Nanoscience and Nanotechnology.  12:6880-6886.

Bidirectional regulation of neutrophil migration by mitogen-activated protein kinases.  Nature Immunology.  13:457-464.

Akt isoforms differentially regulate neutrophil functions.  Blood.  115:4237-4246.

A Novel Function of Sphingosine Kinase 1 Suppression of JNK Activity in Preventing Inflammation and Injury.  Journal of Biological Chemistry.  285:15848-15857.

Applications of Fluorescent Quantum Dots to Stem Cell Tracing In Vivo.  Journal of Nanoscience and Nanotechnology.  9:5726-5730.

Incorporating fluorescent quantum dots into water-soluble polymer.  Journal of Luminescence.  128:277-281.

Applications of mesenchymal stem cells labeled with Tat peptide conjugated quantum dots to cell tracking in mouse body.  Bioconjugate Chemistry.  19:421-427.

NIR Raman spectroscopic investigation of single mitochondria trapped by optical tweezers.  Optics Express.  15:12708-12716.

Inhibition of the activating signals in NK92 cells by recombinant GST-sHLA-G1α chain.  Cell Research.  14:155-160.

Immunoinhibitory effect of soluble HLA-G1 on the cytotoxicity of NK92 cells.  Progress in Natural Science: Materials International.  13:191-195.

Smooth muscle cell ion channels in pulmonary arterial hypertension: Pathogenic role in pulmonary vasoconstriction and vascular remodeling.  295-324.

Deficiency of the Deubiquitinase UCHL1 Attenuates Pulmonary Hypertension.  a1070-a1070.

GALNT1/13 as Novel Mediators of Pulmonary Arterial Hypertension.  a3660-a3660.

Pathogenic Role of Salusin-beta in the Development of Vascular Calcification.  Free Radical Biology and Medicine. S113-S113.

Preventing RhoA Nitration Attenuates NF-?b Dependent Inflammatory Signaling.  Free Radical Biology and Medicine. S127-S127.

Circulating transcriptome as a signature for the diagnosis of pulmonary arterial hypertension.  The FASEB Journal.

Endothelial-dependent activation of smooth muscle PDGF Receptors enhances PASMC proliferation in IPAH.  The FASEB Journal.

Deletion of Rictor in Smooth Muscle Cells Negligibly Affects the Development of Pulmonary Hypertension.  Circulation.

Pathogenic Role of p53 in the Development and Progression of Pulmonary Hypertension.  Circulation.

Capsaicin-sensitive TRPV1 Currents Are Enhanced in Pulmonary Artery Smooth Muscle Cells from Patients with Pulmonary Arterial Hypertension.  The FASEB Journal.

Activation of the Calcium Sensing Receptor potentially inhibits Kv1.5 channel activity.  The FASEB Journal.

Calcium-sensing Receptor, Coupled with Transient Receptor Potential Canonical Channels 6, Regulates Cytosolic [Ca2+] in the Development and Progression of Pulmonary Hypertension.  The FASEB Journal.

Targeting PTEN/Akt/mTOR signaling pathway in pulmonary arterial hypertension.  Journal of Pharmacological Sciences. S61-S61.

A Novel Formulation of Vasoactive Intestinal Peptide Attenuates both Acute Hypoxic Pulmonary Vasoconstriction and the Development of Pulmonary Hypertension.  Circulation.

MiR-17 similar to 92 promotes hypoxia-induced pulmonary hypertension by regulating proliferation and contraction of pulmonary arterial smooth muscle cells.  The FASEB Journal.

Shear stress enhance intracellular Ca2+ in PASMC from patients with idiopathic pulmonary arterial hypertension.  The FASEB Journal.

The crucial role of calcium sensing receptor for hypoxia-induced pulmonary arterial hypertension in mice.  The FASEB Journal.

Distinct Roles of Akt Isoforms in the Development of Hypoxia Induced Pulmonary Hypertension.  Circulation.

ACTIVATION OF AKT/MTOR PATHWAY CONTRIBUTES TO ENHANCED PULMONARY ARTERY SMOOTH MUSCLE CELL PROLIFERATION IN PATIENTS AND ANIMALS WITH PULMONARY ARTERIAL HYPERTENSION.  Journal of Investigative Medicine. 780-780.

Nonmuscle Myosin Light-Chain Kinase Regulates Neutrophil Oxidant Production during LPS Induced Acute Lung Injury..  American Journal of Respiratory and Critical Care Medicine.

Editorial: Mitochondrial Metabolism in Ischemic Heart Disease.  Frontiers in Cardiovascular Medicine.

Editorial: Hypertension: Novel Mechanisms of Nervous and Humoral Regulation.  Frontiers in Pharmacology.

MiRNA208/Mef2 and TNF-α in right ventricular dysfunction: The transition from hypertrophy to failure.  Circulation Research. 6-8.

Corrigendum: Melatonin Promotes the Therapeutic Effect of Mesenchymal Stem Cells on Type 2 Diabetes Mellitus by Regulating TGF-β Pathway (Front. Cell Dev. Biol., (2021), 9, (722365), 10.3389/fcell.2021.722365).  Frontiers in Cell and Developmental Biology.

Is p38 MAPK a Dark Force in Right Ventricular Hypertrophy and Failure in Pulmonary Arterial Hypertension?.  American Journal of Respiratory Cell and Molecular Biology. 506-508.

Pathogenic role of ion channels in pulmonary arterial hypertension.  Experimental Physiology. 1075-1077.

Genetic Insights into Pulmonary Arterial Hypertension Application of Whole-Exome Sequencing to the Study of Pathogenic Mechanisms.  American Journal of Respiratory and Critical Care Medicine. 393-397.

Gasping for answers. Focus on "Calpain activation by ROS mediates human ether-a-go-go-related gene protein degradation by intermittent hypoxia".  American Journal of Physiology - Cell Physiology. C432-C433.

New insights into the pathology of pulmonary hypertension: implication of the miR-210/ISCU1/2/Fe-S axis.  EMBO Molecular Medicine. 689-691.

Raptor and Rictor Both Contribute to the Development and Progression of Pulmonary Arterial Hypertension.  The FASEB Journal.

The Functional Coupling of CaSR and TRPC6 Contributes to Enhanced Proliferation in Pulmonary Arterial Smooth Muscle Cells.  The FASEB Journal.

HIF2α signaling inhibits adherens junctional disruption in acute lung injury (vol 125, pg 652, 2015).  Journal of Clinical Investigation. 1364-1364.

Transient receptor potential channels (TRPC) contribute to an enhanced endothelial cell proliferation and irreversible vascular remodeling associated with the development of pulmonary arterial hypertension (PAH).  The FASEB Journal.

Targeting L-arginine-nitric oxide-cGMP pathway in pulmonary arterial hypertension.  Pulmonary Circulation. 569-571.

Upregulation of Mechanosensitive Channel Piezo1 Involved in High Shear Stress-induced Pulmonary Hypertension

Research Progress on Pulmonary Arterial Hypertension and the Role of the Angiotensin Converting Enzyme 2-Angiotensin-(1–7)-Mas Axis in Pulmonary Arterial Hypertension.  Cardiovascular Drugs and Therapy. 363-370.

Calcium-Sensing Receptor Regulates Cytosolic [Ca²⁺] and Plays a Major Role in the Development of Pulmonary Hypertension.  Frontiers in Physiology.

A process-based review of mouse models of pulmonary hypertension.  Pulmonary Circulation. 415-433.