Transcriptomic profiles in pulmonary arterial hypertension associate with disease severity and identify novel candidate genes Article

Romanoski, CE, Qi, X, Sangam, S et al. (2020). Transcriptomic profiles in pulmonary arterial hypertension associate with disease severity and identify novel candidate genes . PULMONARY CIRCULATION, 10(4), 10.1177/2045894020968531

cited authors

  • Romanoski, CE; Qi, X; Sangam, S; Vanderpool, RR; Stearman, RS; Conklin, A; Gonzalez-Garay, M; Rischard, F; Ayon, RJ; Wang, J; Simonson, T; Babicheva, A; Shi, Y; Tang, H; Makino, A; Kanthi, Y; Geraci, MW; Garcia, JGN; Yuan, JXJ; Desai, AA

authors

abstract

  • Using RNAseq, we identified a 61 gene-based circulating transcriptomic profile most correlated with four indices of pulmonary arterial hypertension severity. In an independent dataset, 13/61 (21%) genes were differentially expressed in lung tissues of pulmonary arterial hypertension cases versus controls, highlighting potentially novel candidate genes involved in pulmonary arterial hypertension development.

publication date

  • January 1, 2020

published in

Digital Object Identifier (DOI)

volume

  • 10

issue

  • 4