Rodriguez Martinez, Myosotys

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Rodriguez Martinez, Myosotys

Positions

Assistant Professor, Cellular and Molecular Medicine , Herbert Wertheim College of Medicine

myrodrig@fiu.edu

biography

Dr. Myosotys Rodriguez is an Assistant Professor in the Department of Cellular and Molecular Medicine at Florida International University. She earned her Ph.D. in Cellular and Molecular Biology from the Department of Microbiology and Immunology at Universidad Central del Caribe School of Medicine, Puerto Rico. During her doctoral research, Dr. Rodriguez explored the interplay between opioid dependence treatment and HIV immunopathology, examining its effects on both the peripheral immune system and the central nervous system (CNS).

In 2015, Dr. Rodriguez joined FIU to initiate postdoctoral training within the El-Hage laboratory. Her focus centered on understanding the role of autophagy in HIV-induced neurocognitive dysfunctions. She explored how autophagy influences metabolic changes in HIV-infected glia, revealing that the activation of the host autophagic pathway by HIV infection is a crucial mechanism for controlling viral replication and viral-induced inflammatory responses. Currently, Dr. Rodriguez's research is dedicated to the intersection of HIV and age-related neurological complications.

research interests

Neurological consequences of HIV infection in the context of aging and cannabinoids

Molecular mechanisms of HIV and substance abuse in the central nervous system

Role of autophagy in glial metabolic dysfunctions induced by HIV

Use of nanotherapy to attenuate HIV neuropathology

selected scholarly works & creative activities

Article
- 2023
  
  Implication of the Autophagy-Related Protein Beclin1 in the Regulation of EcoHIV Replication and Inflammatory Responses
  Full Text via DOI: 10.3390/v15091923 Web of Science: 001072553800001
- 2023
  
  Extracellular Vesicles Released by Genetically Modified Macrophages Activate Autophagy and Produce Potent Neuroprotection in Mouse Model of Lysosomal Storage Disorder, Batten Disease
  Full Text via DOI: 10.3390/cells12111497 Web of Science: 001006182100001
- 2023
  
  SERPIN-Derived Small Peptide (SP16) as a Potential Therapeutic Agent against HIV-Induced Inflammatory Molecules and Viral Replication in Cells of the Central Nervous System
  Full Text via DOI: 10.3390/cells12040632 Web of Science: 000944961200001
- 2022
  
  Using Extracellular Vesicles Released by GDNF-Transfected Macrophages for Therapy of Parkinson Disease
  Full Text via DOI: 10.3390/cells11121933 Web of Science: 000818338200001
- 2021
  
  Different Roles of Beclin 1 in the Interaction Between Glia and Neurons after Exposure to Morphine and the HIV- Trans-Activator of Transcription (Tat) Protein. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. 17:470-486.
  Full Text via DOI: 10.1007/s11481-021-10017-4 Web of Science: 000714824900001
- 2021
  
  Targeting Beclin1 as an Adjunctive Therapy against HIV Using Mannosylated Polyethylenimine Nanoparticles
  Full Text via DOI: 10.3390/pharmaceutics13020223 Web of Science: 000623002300001
- 2020
  
  Reduced-Beclin1-Expressing Mice Infected with Zika-R103451 and Viral-Associated Pathology during Pregnancy
  Full Text via DOI: 10.3390/v12060608 Web of Science: 000551247500001
- 2020
  
  Comparative Cytotoxicity of Inorganic Arsenite and Methylarsenite in Human Brain Cells. ACS CHEMICAL NEUROSCIENCE. 11:743-751.
  Full Text via DOI: 10.1021/acschemneuro.9b00653 Web of Science: 000518702400007
- 2019
  
  GDNF-expressing macrophages restore motor functions at a severe late-stage, and produce long-term neuroprotective effects at an early-stage of Parkinson's disease in transgenic Parkin Q311X(A) mice. JOURNAL OF CONTROLLED RELEASE. 315:139-149.
  Full Text via DOI: 10.1016/j.jconrel.2019.10.027 Web of Science: 000500710700012
- 2019
  
  Morphine counteracts the antiviral effect of antiretroviral drugs and causes upregulation of p62/SQSTM1 and histone-modifying enzymes in HIV-infected astrocytes. JOURNAL OF NEUROVIROLOGY. 25:263-274.
  Full Text via DOI: 10.1007/s13365-018-0715-4 Web of Science: 000467445200013
- 2019
  
  Toll-like receptor 3 regulates Zika virus infection and associated host inflammatory response in primary human astrocytes. PLOS ONE. 14.
  Full Text via DOI: 10.1371/journal.pone.0208543 Web of Science: 000458181200007
- 2018
  
  Critical Role of Beclin1 in HIV Tat and Morphine-Induced Inflammation and Calcium Release in Glial Cells from Autophagy Deficient Mouse. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. 13:355-370.
  Full Text via DOI: 10.1007/s11481-018-9788-3 Web of Science: 000441121100007
- 2017
  
  Importance of Autophagy in Mediating Human Immunodeficiency Virus (HIV) and Morphine-Induced Metabolic Dysfunction and Inflammation in Human Astrocytes. VIRUSES-BASEL. 9.
  Full Text via DOI: 10.3390/v9080201 Web of Science: 000408742900006
- 2017
  
  Intranasal drug delivery of small interfering RNA targeting Beclin1 encapsulated with polyethylenimine (PEI) in mouse brain to achieve HIV attenuation. SCIENTIFIC REPORTS. 7.
  Full Text via DOI: 10.1038/s41598-017-01819-9 Web of Science: 000401262400055
- 2017
  
  Electro-Magnetic Nano-Particle Bound Beclin1 siRNA Crosses the Blood-Brain Barrier to Attenuate the Inflammatory Effects of HIV-1 Infection in Vitro. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. 12:120-132.
  Full Text via DOI: 10.1007/s11481-016-9688-3 Web of Science: 000394969800009
- 2016
  
  beta-Adrenergic receptor gene expression in HIV-associated neurocognitive impairment and encephalitis: implications for MOR-1K subcellular localization. JOURNAL OF NEUROVIROLOGY. 22:866-870.
  Full Text via DOI: 10.1007/s13365-016-0464-1 Web of Science: 000389342900016
- 2015
  
  Differing roles of autophagy in HIV-associated neurocognitive impairment and encephalitis with implications for morphine co-exposure. FRONTIERS IN MICROBIOLOGY. 6.
  Full Text via DOI: 10.3389/fmicb.2015.00653 Web of Science: 000358382000001
- 2015
  
  HIV-1 and Morphine Regulation of Autophagy in Microglia: Limited Interactions in the Context of HIV-1 Infection and Opioid Abuse
  Full Text via DOI: 10.1128/JVI.02022-14 Web of Science: 000347178900012
- 2014
  
  Ibudilast (AV411), and its AV1013 analog, reduce HIV-1 replication and neuronal death induced by HIV-1 and morphine. AIDS. 28:1409-1419.
  Full Text via DOI: 10.1097/QAD.0000000000000291 Web of Science: 000337705400004
- 2014
  
  Opiate Addiction Therapies and HIV-1 Tat: Interactive Effects on Glial [Ca2+](i), Oxyradical and Neuroinflammatory Chemokine Production and Correlative Neurotoxicity. CURRENT HIV RESEARCH. 12:424-434.
  Web of Science: 000351001100007
Book Chapter
- 2024
  
  Neuropathic pain in HIV and the role of the autophagy pathway. 135-146.
  Full Text via DOI: 10.1016/b978-0-323-99744-7.00031-6
Conference
- 2023
  
  SERPIN-Derived Small Peptide (SP16) as a Potential Therapeutic Agent against HIV-Induced Inflammatory Molecules and Viral Replication in Cells of the Central Nervous System. JOURNAL OF NEUROVIROLOGY. S9-S10.
  Web of Science: 001091156000029
- 2018
  
  Different mechanisms implicated in ZIKV-induced inflammatory molecules in human microglial cells. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S60-S60.
  Web of Science: 000429149100207
- 2017
  
  Drug-drug interaction of cART and Morphine mediated by autophagy exacerbates the overall effect of cART in brain. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S38-S38.
  Web of Science: 000414227700084
- 2017
  
  Intranasal administration of small interfering (si) RNA Beclin1 encapsulated with linear polyethylenimine (PEI) nano-plexes to attenuate HIV-1 infection in the brain. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S69-S70.
  Web of Science: 000414227700167
- 2016
  
  ROLE OFAUTOPHAGYON HIV-INFECTED HUMAN ASTROCYTES FUNCTIONALITY.. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S41-S41.
  Web of Science: 000377566000105
- 2015
  
  Differing roles of autophagy in HIV-associated Neurocognitive Impairment and Encephalitis with Implications for Morphine Co-exposure. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S96-S97.
  Web of Science: 000367554100105
- 2015
  
  Methanandamide bound to Magnetic Electric Nanoparticle did not compromise resistance and permeability of the Blood Brain Barrier. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S111-S111.
  Web of Science: 000367554100144
- 2009
  
  Comparative Immunovirological Study between Buprenorphine and Methadone Using Human Lymphocytes and Glial Cells. JOURNAL OF NEUROVIROLOGY. 80-81.
  Web of Science: 000270278700166
Other Scholarly Work
- 2022
  
  GDNF-expressing macrophages restore motor functions at a severe late-stage and produce long-term neuroprotective effects at an early-stage of Parkinson's disease in transgenic Parkin Q311X(A) mice (vol 315, pg 139, 2019). JOURNAL OF CONTROLLED RELEASE. 813-814.
  Full Text via DOI: 10.1016/j.jconrel.2022.01.007 Web of Science: 000802746900001
- 2018
  
  Intranasal drug delivery of small interfering RNA targeting Beclin1 encapsulated with polyethylenimine (PEI) in mouse brain to achieve HIV attenuation (vol 7, year 2017). SCIENTIFIC REPORTS.
  Full Text via DOI: 10.1038/s41598-018-23078-y Web of Science: 000427370700001
Preprint
- Zika virus infection during pregnancy and induced brain pathology in beclin1-deficient mouse model
  Full Text via DOI: 10.1101/843813
Review
- 2020
  
  Impact of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in the Nervous System: Implications of COVID-19 in Neurodegeneration. FRONTIERS IN NEUROLOGY.
  Full Text via DOI: 10.3389/fneur.2020.583459 Web of Science: 000593917400001
- 2018
  
  Autophagy, EVs, and Infections: A Perfect Question for a Perfect Time. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY.
  Full Text via DOI: 10.3389/fcimb.2018.00362 Web of Science: 000447588800001
- 2018
  
  Complementary Mechanisms Potentially Involved in the Pathology of Zika Virus. FRONTIERS IN IMMUNOLOGY.
  Full Text via DOI: 10.3389/fimmu.2018.02340 Web of Science: 000447256100001
- 2017
  
  Interplay between Autophagy, Exosomes and HIV-1 Associated Neurological Disorders: New Insights for Diagnosis and Therapeutic Applications. VIRUSES-BASEL.
  Full Text via DOI: 10.3390/v9070176 Web of Science: 000406684400018
- 2017
  
  HIV-1 Transcription Inhibitors Increase the Synthesis of Viral Non-Coding RNA that Contribute to Latency. CURRENT PHARMACEUTICAL DESIGN. 4133-4144.
  Full Text via DOI: 10.2174/1381612823666170622101319 Web of Science: 000414366900008
- 2016
  
  Mammalian microRNA: an important modulator of host-pathogen interactions in human viral infections. JOURNAL OF BIOMEDICAL SCIENCE.
  Full Text via DOI: 10.1186/s12929-016-0292-x Web of Science: 000386719500001

principal investigator on

Neurocognitive implications of cannabidiol (CBD) while aging with HIV awarded by National Institute on Drug Abuse 2022 - 2024

investigator on

full name

Myosotys Rodriguez Martinez

ORCID iD

https://orcid.org/0000-0002-3925-9023 (confirmed)

visualizations

Co-author Network

Co-investigator Network

publication subject areas

Citation index-derived subject areas the researcher has published in