Scholarly & Creative Works
Patents issued
selected scholarly works & creative activities
-
Article
-
2025Induced pluripotent stem cell-derived cardiomyocyte in vitro models: benchmarking progress and ongoing challengesFull Text via DOI: 10.1038/s41592-024-02480-7 Web of Science: 001350186900002
-
2024Computational Model for Early-Stage Aortic Valve Calcification Shows Hemodynamic BiomarkersFull Text via DOI: 10.3390/bioengineering11100955 Web of Science: 001343173900001
-
2022Importance of Non-Newtonian Computational Fluid Modeling on Severely Calcified Aortic Valve Geometries-Insights From Quasi-Steady State Simulations. JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME. 144.Full Text via DOI: 10.1115/1.4054630 Web of Science: 000864547500006
-
2022Investigating the Transient Regenerative Potential of Cardiac Muscle Using a Neonatal Pig Partial Apical Resection ModelFull Text via DOI: 10.3390/bioengineering9080401 Web of Science: 000847021800001
-
2022Valve Endothelial Cell Exposure to High Levels of Flow Oscillations Exacerbates Valve Interstitial Cell CalcificationFull Text via DOI: 10.3390/bioengineering9080393 Web of Science: 000847078100001
-
2022Directional dependence on concomitant pressure and volume increases during left ventricular filling. JOURNAL OF BIOMECHANICS. 138.Full Text via DOI: 10.1016/j.jbiomech.2022.111129 Web of Science: 000807944100005
-
2021De Novo Valve Tissue Morphology Following Bioscaffold Mitral Valve Replacement in a Juvenile Non-Human Primate ModelFull Text via DOI: 10.3390/bioengineering8070100 Web of Science: 000675955000001
-
2021Constitutive Properties of Mitral Valve Tissues via NanoindentationFull Text via DOI: 10.1080/24748706.2021.1901492
-
2020Physiologically Relevant Fluid-Induced Oscillatory Shear Stress Stimulation of Mesenchymal Stem Cells Enhances the Engineered Valve Matrix Phenotype. FRONTIERS IN CARDIOVASCULAR MEDICINE. 7.Full Text via DOI: 10.3389/fcvm.2020.00069 Web of Science: 000538876300001
-
2020Uncovering the Mechanical, Thermal, and Chemical Characteristics of Biodegradable Mushroom Leather with Intrinsic Antifungal and Antibacterial Properties. ACS APPLIED BIO MATERIALS. 3:3145-3156.Full Text via DOI: 10.1021/acsabm.0c00164 Web of Science: 000604588000061
-
2020Porcine Small Intestinal Submucosa Mitral Valve Material Responses Support Acute Somatic Growth. TISSUE ENGINEERING PART A. 26:475-489.Full Text via DOI: 10.1089/ten.tea.2019.0220 Web of Science: 000507618900001
-
2020Communication-Detection of Salivary Cortisol Using Zinc Oxide and Copper Porphyrin Composite Using Electrodeposition and Plasma-Assisted Deposition. ECS JOURNAL OF SOLID STATE SCIENCE AND TECHNOLOGY. 9.Full Text via DOI: 10.1149/2162-8777/aba856 Web of Science: 000557407700001
-
2019Elastin-Dependent Aortic Heart Valve Leaflet Curvature Changes During Cyclic FlexureFull Text via DOI: 10.3390/bioengineering6020039 Web of Science: 000475298500012
-
2018Stem Cell Cytoskeletal Responses to Pulsatile Flow in Heart Valve Tissue Engineering Studies. FRONTIERS IN CARDIOVASCULAR MEDICINE. 5.Full Text via DOI: 10.3389/fcvm.2018.00058 Web of Science: 000440689200001
-
2017A "sweet-spot" for fluid-induced oscillations in the conditioning of stem cell-based engineered heart valve tissues. JOURNAL OF BIOMECHANICS. 65:40-48.Full Text via DOI: 10.1016/j.jbiomech.2017.09.035 Web of Science: 000417665400005
-
2017Hydrodynamic Assessment of Aortic Valves Prepared from Porcine Small Intestinal Submucosa. CARDIOVASCULAR ENGINEERING AND TECHNOLOGY. 8:30-40.Full Text via DOI: 10.1007/s13239-016-0290-x Web of Science: 000394974400004
-
2016Use of combined polarization-sensitive optical coherence tomography and Mueller matrix imaging for the polarimetric characterization of excised biological tissue. JOURNAL OF BIOMEDICAL OPTICS. 21.Full Text via DOI: 10.1117/1.JBO.21.7.071109 Web of Science: 000381917800012
-
2016Relative Effects of Fluid Oscillations and Nutrient Transport in the In Vitro Growth of Valvular Tissues. CARDIOVASCULAR ENGINEERING AND TECHNOLOGY. 7:170-181.Full Text via DOI: 10.1007/s13239-016-0258-x Web of Science: 000380359100007
-
2016Integration of Stem Cell to Chondrocyte-Derived Cartilage Matrix in Healthy and Osteoarthritic States in the Presence of Hydroxyapatite Nanoparticles. PLOS ONE. 11.Full Text via DOI: 10.1371/journal.pone.0149121 Web of Science: 000370054100108
-
2015Differentiation and Distribution of Marrow Stem Cells in Flex-Flow Environments Demonstrate Support of the Valvular Phenotype. PLOS ONE. 10.Full Text via DOI: 10.1371/journal.pone.0141802 Web of Science: 000364298400089
-
2015Utility of magneto-electropolished ternary nitinol alloys for blood contacting applications. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS. 103:1366-1374.Full Text via DOI: 10.1002/jbm.b.33317 Web of Science: 000363693600004
-
2015Three Dimensional Graphene Foam/Polymer Hybrid as a High Strength Biocompatible Scaffold. ADVANCED FUNCTIONAL MATERIALS. 25:3916-3924.Full Text via DOI: 10.1002/adfm.201500876 Web of Science: 000357268900014
-
2014A Novel Bioreactor for Mechanobiological Studies of Engineered Heart Valve Tissue Formation Under Pulmonary Arterial Physiological Flow Conditions. JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME. 136.Full Text via DOI: 10.1115/1.4028815 Web of Science: 000345154300009
-
2014Computational simulations predict a key role for oscillatory fluid shear stress in de novo valvular tissue formation. JOURNAL OF BIOMECHANICS. 47:3517-3523.Full Text via DOI: 10.1016/j.jbiomech.2014.08.028 Web of Science: 000345183500013
-
2014Augmentation of engineered cartilage to bone integration using hydroxyapatite. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS. 102:922-932.Full Text via DOI: 10.1002/jbm.b.33073 Web of Science: 000337667900004
-
2014Oscillatory shear stress created by fluid pulsatility versus flexed specimen configurations. COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING. 17:728-739.Full Text via DOI: 10.1080/10255842.2012.715157 Web of Science: 000334049900005
-
2013Protocol for Relative Hydrodynamic Assessment of Tri-leaflet Polymer Valves. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS.Full Text via DOI: 10.3791/50335-v
-
2013Monitoring Steady Flow Effects on Cell Distribution in Engineered Valve Tissues by Magnetic Resonance Imaging. MOLECULAR IMAGING. 12.Full Text via DOI: 10.2310/7290.2013.00063 Web of Science: 000336725500004
-
2013Protocol for Relative Hydrodynamic Assessment of Tri-leaflet Polymer Valves. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS.Full Text via DOI: 10.3791/50335 Web of Science: 000209228800004
-
2013Glycosaminoglycan entrapment by fibrin in engineered heart valve tissues. ACTA BIOMATERIALIA. 9:8149-8157.Full Text via DOI: 10.1016/j.actbio.2013.06.009 Web of Science: 000323402600012
-
2013Relative survivability of human osteoblasts is enhanced by 39 A degrees C and ascorbic acid after exposure to photopolymerization ingredients. CYTOTECHNOLOGY. 65:587-596.Full Text via DOI: 10.1007/s10616-012-9512-8 Web of Science: 000322171800013
-
2013Periodontal Ligament Cells Cultured Under Steady-Flow Environments Demonstrate Potential for Use in Heart Valve Tissue Engineering. TISSUE ENGINEERING PART A. 19:458-466.Full Text via DOI: 10.1089/ten.tea.2012.0149 Web of Science: 000313423700014
-
2012Graphene Nanoplatelet-Induced Strengthening of UltraHigh Molecular Weight Polyethylene and Biocompatibility In vitro. ACS APPLIED MATERIALS & INTERFACES. 4:2234-2241.Full Text via DOI: 10.1021/am300244s Web of Science: 000303139900051
-
2012Corrosionand Biocompatibility Assessment of Magnesium AlloysFull Text via DOI: 10.4236/jbnb.2012.31002
-
2010Compatibility of Superparamagnetic Iron Oxide Nanoparticle Labeling for H-1 MRI Cell Tracking with P-31 MRS for Bioenergetic Measurements. NMR IN BIOMEDICINE. 23:1166-1172.Full Text via DOI: 10.1002/nbm.1545 Web of Science: 000285948600006
-
2010Characterization of Ex Vivo-Generated Bovine and Human Cartilage by Immunohistochemical, Biochemical, and Magnetic Resonance Imaging Analyses. TISSUE ENGINEERING PART A. 16:2183-2196.Full Text via DOI: 10.1089/ten.tea.2009.0717 Web of Science: 000279455500008
-
2010The role of organ level conditioning on the promotion of engineered heart valve tissue development in-vitro using mesenchymal stem cells. BIOMATERIALS. 31:1114-1125.Full Text via DOI: 10.1016/j.biomaterials.2009.10.019 Web of Science: 000273985100011
-
2009Magnetic Resonance Imaging of Chondrocytes Labeled with Superparamagnetic Iron Oxide Nanoparticles in Tissue-Engineered Cartilage. TISSUE ENGINEERING PART A. 15:3899-3910.Full Text via DOI: 10.1089/ten.tea.2008.0677 Web of Science: 000272528400021
-
2008Assessment of tissue repair in full thickness chondral defects in the rabbit using magnetic resonance imaging transverse relaxation measurements. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS. 86B:375-380.Full Text via DOI: 10.1002/jbm.b.31030 Web of Science: 000257929400010
-
2007Fourier transform infrared imaging and MR microscopy studies detect compositional and structural changes in cartilage in a rabbit model of osteoarthritis. ANALYTICAL AND BIOANALYTICAL CHEMISTRY. 387:1601-1612.Full Text via DOI: 10.1007/s00216-006-0910-7 Web of Science: 000244335000006
-
2006Resveratrol improves health and survival of mice on a high-calorie diet. NATURE. 444:337-342.Full Text via DOI: 10.1038/nature05354 Web of Science: 000242018300041
-
2006An analysis of the integration between articular cartilage and nondegradable hydrogel using magnetic resonance imaging. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS. 77B:144-148.Full Text via DOI: 10.1002/jbm.b.30404 Web of Science: 000236262000020
-
2006Comparison of left anterior descending coronary artery hemodynamics before and after angioplasty. JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME. 128:40-48.Full Text via DOI: 10.1115/1.2132371 Web of Science: 000235264700007
-
2004Fluid dynamic analysis in a human left anterior descending coronary artery with arterial motion. ANNALS OF BIOMEDICAL ENGINEERING. 32:1628-1641.Full Text via DOI: 10.1007/s10439-004-7816-3 Web of Science: 000226094100004
-
-
Book Chapter
-
2025Revolutionizing Pediatric Valve Replacement: The Future of Elastin-Rich Tissue-Engineered Solutions. 291-307.Full Text via DOI: 10.1007/978-3-031-81743-4_10
-
2019Novel bioreactors for mechanistic studies of engineered heart valves. 319-335.Full Text via DOI: 10.1007/978-3-030-01993-8_13
-
2017SPIO‐Labeled Cellular MRI in Tissue Engineering. 71-89.Full Text via DOI: 10.1002/9781119193272.ch4
-
2017
-
2012Biomechanics of heart valves. 175-194.
-
-
Conference
-
2018Recapitulation of Human Bio-Scaffold Mitral Valve Growth in the Baboon Model.. CIRCULATION.Web of Science: 000528619400486
-
2018Multiphoton microscopy of ECM proteins in baboon aortic leaflet. ADVANCED BIOMEDICAL AND CLINICAL DIAGNOSTIC SYSTEMS VII.Full Text via DOI: 10.1117/12.2291024 Web of Science: 000435025800005
-
2017EARLY HYDRODYNAMIC ASSESSMENT OF INTESTINAL SUB-MUCOSA BIOSCAFFOLD FOR MITRAL VALVE REPLACEMENT. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 590-590.Full Text via DOI: 10.1016/S0735-1097(17)33979-7 Web of Science: 000397342301112
-
2013In-vitro Degradation and Cytocompatibility Assessment of Mg-Zn and Mg-Zn-Ca Alloys. 104-107.Web of Science: 000319085000022
-
2012
-
2011Novel design to integrate tissue engineered cartilage to native bone using hydroxyapatite nanoparticles. 418-420.Full Text via DOI: 10.1109/ICONSET.2011.6167992
-
2011SPECIMEN DYNAMICS AND SUBSEQUENT IMPLICATIONS IN HEART VALVE TISSUE ENGINEERING STUDIES. 1055-1056.Web of Science: 000320411400527
-
2001Four-dimensional coronary morphology and computational hemodynamics. ADVANCED BIOMEDICAL AND CLINICAL DIAGNOSTIC SYSTEMS VII. 743-754.Full Text via DOI: 10.1117/12.431153 Web of Science: 000172146600078
-
2001Virtual angioscopy in human coronary arteries with visualization of computational hemodynamics. ADVANCED BIOMEDICAL AND CLINICAL DIAGNOSTIC SYSTEMS VII. 32-43.Full Text via DOI: 10.1117/12.428164 Web of Science: 000171469100004
-
Editorial Material
-
Other Scholarly Work
-
2021Editorial: Extracellular Matrix for Cardiovascular Reconstruction. FRONTIERS IN CARDIOVASCULAR MEDICINE.Full Text via DOI: 10.3389/fcvm.2021.664803 Web of Science: 000641975300001
-
2020Oscillatory fluid-induced mechanobiology in heart valves with parallels to the vasculature.. R59-R71.Full Text via DOI: 10.1530/vb-19-0031
-
2017Use of combined polarization-sensitive optical coherence tomography and Mueller matrix imaging for the polarimetric characterization of excised biological tissue (vol 21, 071109, 2016). JOURNAL OF BIOMEDICAL OPTICS.Full Text via DOI: 10.1117/1.JBO.22.10.109801 Web of Science: 000414251000034
-
2016Surface modification of Ni-Ti alloys for stent application after magnetoelectropolishing (vol 50, pg 37, 2015). MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS. 454-454.Full Text via DOI: 10.1016/j.msec.2016.02.030 Web of Science: 000376547700055
-
2014Oscillatory shear stress created by fluid pulsatility versus flexed specimen configurations. COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING. 932-932.Full Text via DOI: 10.1080/10255842.2012.741806 Web of Science: 000334075400011
-
-
Review
-
2012Superparamagnetic iron oxide (SPIO) labeling efficiency and subsequent MRI tracking of native cell populations pertinent to pulmonary heart valve tissue engineering studies. NMR IN BIOMEDICINE. 410-417.Full Text via DOI: 10.1002/nbm.1642 Web of Science: 000300670600004
-
Research
principal investigator on
- Additional In Vitro Assessments of Decellularized and Dehydrated Augmented Elastin Heart Valve to Confirm its Functionality, Durability and Cellular Responses awarded by Miami Heart Research Institute 2023 - 2024
- PFI-TT: Injectable Enhanced Stem Cell Exosomes for Restoration of Heart Function awarded by National Science Foundation 2020 - 2023
- Stem Cell-seeded bioscaffolds supporting somatic growth, function and remodeling in the treatment of critical congenital valve disease in the young. awarded by Florida Heart Research Foundation Inc 2021 - 2022
- Hydrodynamic testing of a seamless bioscaffold valve design in the mitral location awarded by Cormatrix Cardiovascular Inc. 2020 - 2021
- Stem Cell-seeded bioscaffolds supporting somatic growth, function and remodeling in the treatment of critical congenital valve disease in the young. awarded by Florida Heart Research Foundation Inc 2018 - 2021
- Terminal Sterilization awarded by Vivex Biomedical Inc 2018 - 2019
- Bioscaffold mitral valve replacement permitting somatic growth and remodeling awarded by American Heart Association 2016 - 2019
- I-Corps: Mechanically Conditioned 3-Dimensional Cell Culture System awarded by National Science Foundation 2016 - 2018
- Fatigue and constitutive properties of novel stent-grafts awarded by Saint George Medical Inc 2012 - 2014
- Hydrodynamic testing of a novel tri-leaflet silicone valve at four anatomically-relevant locations awarded by FIU Foundation 2012 - 2013
- Noninvasive Detection and Tracking of Cell Populations in the Development and Remodeling of Engineered Heart Valves awarded by American Heart Association 2010 - 2012
co-principal investigator on
-
Grant
- FIU I-Corps Teams Funding awarded by National Science Foundation 2016
investigator on
- Thrust 2: NSF ERC: Nanosystems Engineering Research Center for Directed Multiscale Assembly of Cellular Metamaterials with Nanoscale Precision: CELL-MET awarded by National Science Foundation 2021 - 2022
- Thrust 2: NST ERC: Nanosystems Engineering Research Center for Directed Multiscale Assembly of Cellular Metamaterials with Nanoscale Precision: CELL-MET awarded by National Science Foundation 2020 - 2021
- NST ERC: CELL-MET-Thrust 2 awarded by National Science Foundation 2019 - 2020
Identifiers
ORCID iD
- https://orcid.org/0000-0003-4108-7141 (confirmed)
visualizations
publication subject areas
Citation index-derived subject areas the researcher has published in