Lakshmana, Madepalli Graduate Faculty

Positions

overview

  • Madepalli Lakshmana, Ph.D. is an expert in Alzheimer’s disease (AD) with more than twenty years of experience in the field of neurodegeneration research. Dr. Lakshmana acquired basic concepts and advanced knowledge on the brain and nervous system through mandatory course work during MS, M.Phil, and Ph.D. training programs. One major focus of Dr. Lakshmana’s research is to identify molecules and pathways responsible for enhanced Aβ generation and hyperphosphorylated tau in models of AD so that those molecules can be targeted for the therapeutic benefit of AD patients. Towards this goal, Dr. Lakshmana has identified RanBP9 in a large protein complex that includes LRP, APP, BACE1, and COPS5. By generating several lines of transgenic and knockout mouse models, he could demonstrate that each one of this protein complex plays a crucial role in the amyloidogenic processing of APP and Aβ generation. After joining FIU in 2018, he has expanded his research interests to include other neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) for which also the molecular basis for neurodegeneration is still elusive.

selected scholarly works & creative activities

full name

  • Madepalli Lakshmana

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