Kim, Lou

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Kim, Lou Graduate Faculty

Positions

Associate Professor, Biological Sciences , College of Arts, Sciences & Education

kiml@fiu.edu

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biography

Uncover the mechanisms of cell differentiation and motility control using Dictyostelium as a model organism

His research group is studying multicellular development and eukaryotic chemotaxis using Dictyostelium as a model organism. Research focus is on the mechanism of Cell Fate Decision by GSK3, PP2A/ B56/PTPA, ZAK and the regulation of Eukaryotic Chemotaxis by regulation of phosphoinositol-(3,4,5)-triphosphate (PIP3).

research interests

Mechanisms of cell differentiation and motility control using Dictyostelium as a model organism

selected scholarly works & creative activities

Article
- 2024
  
  An integrated, cross-regulation pathway model involving activating/adaptive and feed-forward/feed-back loops for directed oscillatory cAMP signal-relay/response during the development of Dictyostelium. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 11.
  Full Text via DOI: 10.3389/fcell.2023.1263316 Web of Science: 001161769900001
- 2020
  
  Superoxide dismutase C affects Dictyostelium contractile vacuole biogenesis and function. DEVELOPMENT GROWTH & DIFFERENTIATION. 62:516-526.
  Full Text via DOI: 10.1111/dgd.12698 Web of Science: 000596714300001
- 2018
  
  Curcumin and derivatives function through protein phosphatase 2A and presenilin orthologues in Dictyostelium discoideum. DISEASE MODELS & MECHANISMS. 11.
  Full Text via DOI: 10.1242/dmm.032375 Web of Science: 000423805100015
- 2017
  
  SodC modulates ras and PKB signaling in Dictyostelium. EUROPEAN JOURNAL OF CELL BIOLOGY. 96:1-12.
  Full Text via DOI: 10.1016/j.ejcb.2016.11.001 Web of Science: 000393543000001
- 2015
  
  PP2A/B56 and GSK3/Ras suppress PKB activity during Dictyostelium chemotaxis. MOLECULAR BIOLOGY OF THE CELL. 26:4347-4357.
  Full Text via DOI: 10.1091/mbc.E14-06-1130 Web of Science: 000366326500007
- 2013
  
  Glycogen Synthase Kinase 3 influences cell motility and chemotaxis by regulating PI3K membrane localization in Dictyostelium. DEVELOPMENT GROWTH & DIFFERENTIATION. 55:723-734.
  Full Text via DOI: 10.1111/dgd.12078 Web of Science: 000325616500004
- 2011
  
  Combinatorial cell-specific regulation of GSK3 directs cell differentiation and polarity in Dictyostelium. DEVELOPMENT. 138:421-430.
  Full Text via DOI: 10.1242/dev.055335 Web of Science: 000285872800004
- 2011
  
  LKB1 regulates development and the stress response in Dictyostelium. DEVELOPMENTAL BIOLOGY. 360:351-357.
  Full Text via DOI: 10.1016/j.ydbio.2011.10.006
- 2008
  
  The GPI-anchored superoxide dismutase SodC is essential for regulating basal Ras activity and for chemotaxis of Dictyostelium discoideum. JOURNAL OF CELL SCIENCE. 121:3099-3108.
  Full Text via DOI: 10.1242/jcs.030056
- 2008
  
  Dictyostelium kinase DPYK3 negatively regulates STATc signaling in cell fate decision. DEVELOPMENT GROWTH & DIFFERENTIATION. 50:607-613.
  Full Text via DOI: 10.1111/j.1440-169X.2008.01058.x Web of Science: 000258287000008
- 2008
  
  MPL1, a novel phosphatase with leucine-rich repeats, is essential for proper ERK2 phosphorylation and cell motility. EUKARYOTIC CELL. 7:958-966.
  Full Text via DOI: 10.1128/EC.00442-07 Web of Science: 000258666300005
- 2008
  
  The function of PP2A/B56 in non-metazoan multicellular development. DIFFERENTIATION. 76:1104-1110.
  Full Text via DOI: 10.1111/j.1432-0436.2008.00301.x
- 2002
  
  Receptor-dependent and tyrosine phosphatase-mediated inhibition of GSK3 regulates cell fate choice. DEVELOPMENTAL CELL. 3:523-532.
  Full Text via DOI: 10.1016/S1534-5807(02)00269-1
- 2000
  
  Cell volume-dependent phosphorylation of proteins of the cortical cytoskeleton and cell-cell contact sites. The role of Fyn and FER kinases. JOURNAL OF BIOLOGICAL CHEMISTRY. 275:32289-32298.
  Full Text via DOI: 10.1074/jbc.M003172200
- 2000
  
  Regulated interactions between dynamin and the actin-binding protein cortactin modulate cell shape
  Full Text via DOI: 10.1083/jcb.151.1.187
- 1999
  
  The novel tyrosine kinase ZAK1 activates GSK3 to direct cell fate specification
  Full Text via DOI: 10.1016/S0092-8674(00)81526-3
- 1998
  
  Growth factor-dependent phosphorylation of the actin-binding protein cortactin is mediated by the cytoplasmic tyrosine kinase FER. JOURNAL OF BIOLOGICAL CHEMISTRY. 273:23542-23548.
  Full Text via DOI: 10.1074/jbc.273.36.23542
- 1995
  
  The cytoplasmic tyrosine kinase FER is associated with the catenin-like substrate pp120 and is activated by growth factors. MOLECULAR AND CELLULAR BIOLOGY. 15:4553-4561.
  Full Text via DOI: 10.1128/MCB.15.8.4553
Review
- 2017
  
  Dual TORCs driven and B56 orchestrated signaling network guides eukaryotic cell migration. BMB REPORTS. 437-444.
  Full Text via DOI: 10.5483/BMBRep.2017.50.9.091 Web of Science: 000412955100002
- 2009
  
  Glycogen synthase kinase 3 in the world of cell migration. DEVELOPMENT GROWTH & DIFFERENTIATION. 735-742.
  Full Text via DOI: 10.1111/j.1440-169X.2009.01141.x Web of Science: 000272192400001
- 2006
  
  GSK3 at the edge: Regulation of developmental specification and cell polarization. CURRENT DRUG TARGETS. 1411-1419.
  Full Text via DOI: 10.2174/1389450110607011411
- 2000
  
  GSK3, a master switch regulating cell-fate specification and tumorigenesis. 508-514.
  Full Text via DOI: 10.1016/S0959-437X(00)00120-9

principal investigator on

DORBRDG - Bridge Funding for Dr. Kim awarded by FIU Office of Research and Economic Deve 2014 - 2016
PP2A Regulates development and stress responses awarded by National Cancer Institute 2009 - 2014

subproject principal investigator on

2007-2008 MBRS Support of Continuous Research Excellence at FIU. awarded by General Medical Sciences 2007 - 2009

full name

Lou Kim

ORCID iD

https://orcid.org/0000-0002-2693-7569 (confirmed)

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