Kim, Lou Graduate Faculty
- Associate Professor, Biological Sciences , College of Arts, Sciences & Education
Overview
biography
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Uncover the mechanisms of cell differentiation and motility control using Dictyostelium as a model organism
His research group is studying multicellular development and eukaryotic chemotaxis using Dictyostelium as a model organism. Research focus is on the mechanism of Cell Fate Decision by GSK3, PP2A/ B56/PTPA, ZAK and the regulation of Eukaryotic Chemotaxis by regulation of phosphoinositol-(3,4,5)-triphosphate (PIP3).
research interests
- Mechanisms of cell differentiation and motility control using Dictyostelium as a model organism
Scholarly & Creative Works
selected scholarly works & creative activities
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Article
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2024An integrated, cross-regulation pathway model involving activating/adaptive and feed-forward/feed-back loops for directed oscillatory cAMP signal-relay/response during the development of Dictyostelium. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 11.Full Text via DOI: 10.3389/fcell.2023.1263316 Web of Science: 001161769900001
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2020Superoxide dismutase C affects Dictyostelium contractile vacuole biogenesis and function. DEVELOPMENT GROWTH & DIFFERENTIATION. 62:516-526.Full Text via DOI: 10.1111/dgd.12698 Web of Science: 000596714300001
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2018Curcumin and derivatives function through protein phosphatase 2A and presenilin orthologues in Dictyostelium discoideum. DISEASE MODELS & MECHANISMS. 11.Full Text via DOI: 10.1242/dmm.032375 Web of Science: 000423805100015
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2017SodC modulates ras and PKB signaling in Dictyostelium. EUROPEAN JOURNAL OF CELL BIOLOGY. 96:1-12.Full Text via DOI: 10.1016/j.ejcb.2016.11.001 Web of Science: 000393543000001
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2015PP2A/B56 and GSK3/Ras suppress PKB activity during Dictyostelium chemotaxis. MOLECULAR BIOLOGY OF THE CELL. 26:4347-4357.Full Text via DOI: 10.1091/mbc.E14-06-1130 Web of Science: 000366326500007
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2013Glycogen Synthase Kinase 3 influences cell motility and chemotaxis by regulating PI3K membrane localization in Dictyostelium. DEVELOPMENT GROWTH & DIFFERENTIATION. 55:723-734.Full Text via DOI: 10.1111/dgd.12078 Web of Science: 000325616500004
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2011Combinatorial cell-specific regulation of GSK3 directs cell differentiation and polarity in Dictyostelium. DEVELOPMENT. 138:421-430.Full Text via DOI: 10.1242/dev.055335 Web of Science: 000285872800004
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2011LKB1 regulates development and the stress response in Dictyostelium. DEVELOPMENTAL BIOLOGY. 360:351-357.Full Text via DOI: 10.1016/j.ydbio.2011.10.006
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2008The GPI-anchored superoxide dismutase SodC is essential for regulating basal Ras activity and for chemotaxis of Dictyostelium discoideum. JOURNAL OF CELL SCIENCE. 121:3099-3108.Full Text via DOI: 10.1242/jcs.030056
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2008Dictyostelium kinase DPYK3 negatively regulates STATc signaling in cell fate decision. DEVELOPMENT GROWTH & DIFFERENTIATION. 50:607-613.Full Text via DOI: 10.1111/j.1440-169X.2008.01058.x Web of Science: 000258287000008
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2008MPL1, a novel phosphatase with leucine-rich repeats, is essential for proper ERK2 phosphorylation and cell motility. EUKARYOTIC CELL. 7:958-966.Full Text via DOI: 10.1128/EC.00442-07 Web of Science: 000258666300005
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2008The function of PP2A/B56 in non-metazoan multicellular development. DIFFERENTIATION. 76:1104-1110.Full Text via DOI: 10.1111/j.1432-0436.2008.00301.x
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2002Receptor-dependent and tyrosine phosphatase-mediated inhibition of GSK3 regulates cell fate choice. DEVELOPMENTAL CELL. 3:523-532.Full Text via DOI: 10.1016/S1534-5807(02)00269-1
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2000Cell volume-dependent phosphorylation of proteins of the cortical cytoskeleton and cell-cell contact sites. The role of Fyn and FER kinases. JOURNAL OF BIOLOGICAL CHEMISTRY. 275:32289-32298.Full Text via DOI: 10.1074/jbc.M003172200
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1998Growth factor-dependent phosphorylation of the actin-binding protein cortactin is mediated by the cytoplasmic tyrosine kinase FER. JOURNAL OF BIOLOGICAL CHEMISTRY. 273:23542-23548.Full Text via DOI: 10.1074/jbc.273.36.23542
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1995The cytoplasmic tyrosine kinase FER is associated with the catenin-like substrate pp120 and is activated by growth factors. MOLECULAR AND CELLULAR BIOLOGY. 15:4553-4561.Full Text via DOI: 10.1128/MCB.15.8.4553
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Other Scholarly Work
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2024Procedures to Measure Dictyostelium Phagocytosis and Macropinocytosis. 81-88.Full Text via DOI: 10.1007/978-1-0716-3894-1_5
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2024Quantitative Analysis of the Inactivation Process of Internalized Bacteria in Dictyostelium Cells. 89-96.Full Text via DOI: 10.1007/978-1-0716-3894-1_6
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Review
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2017Dual TORCs driven and B56 orchestrated signaling network guides eukaryotic cell migration. BMB REPORTS. 437-444.Full Text via DOI: 10.5483/BMBRep.2017.50.9.091 Web of Science: 000412955100002
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2009Glycogen synthase kinase 3 in the world of cell migration. DEVELOPMENT GROWTH & DIFFERENTIATION. 735-742.Full Text via DOI: 10.1111/j.1440-169X.2009.01141.x Web of Science: 000272192400001
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2006GSK3 at the edge: Regulation of developmental specification and cell polarization. CURRENT DRUG TARGETS. 1411-1419.Full Text via DOI: 10.2174/1389450110607011411
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2000GSK3, a master switch regulating cell-fate specification and tumorigenesis. 508-514.Full Text via DOI: 10.1016/S0959-437X(00)00120-9
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Research
principal investigator on
- DORBRDG - Bridge Funding for Dr. Kim awarded by FIU Office of Research and Economic Deve 2014 - 2016
- PP2A Regulates development and stress responses awarded by National Cancer Institute 2009 - 2014
subproject principal investigator on
- 2007-2008 MBRS Support of Continuous Research Excellence at FIU. awarded by General Medical Sciences 2007 - 2009
Contact
full name
- Lou Kim
Identifiers
ORCID iD
- https://orcid.org/0000-0002-2693-7569 (confirmed)
visualizations
publication subject areas
Citation index-derived subject areas the researcher has published in