GSK3, a master switch regulating cell-fate specification and tumorigenesis
Review
Kim, L, Kimmel, AR. (2000). GSK3, a master switch regulating cell-fate specification and tumorigenesis
. Current Opinion in Genetics and Development, 10(5), 508-514. 10.1016/S0959-437X(00)00120-9
Kim, L, Kimmel, AR. (2000). GSK3, a master switch regulating cell-fate specification and tumorigenesis
. Current Opinion in Genetics and Development, 10(5), 508-514. 10.1016/S0959-437X(00)00120-9
Until recently, protein kinase GSK3 (glycogen synthase kinase 3), an essential component for cell-fate specification, had been considered a constitutively activated enzyme subject to developmentally regulated inhibition through hierarchical, linear signaling paths. Data from various systems now indicate more complex scenarios involving activating as well as inhibiting circuits, and the differential formation of multi-protein complexes that antagonistically affect GSK3 function.
