FIU Discovery

Radiolabeled Aminopyrazoles as Novel Isoform Selective Probes for pJNK3 Quantification.  ACS MEDICINAL CHEMISTRY LETTERS.  13:1606-1614.

Novel and Structurally Diversified Bacterial DNA Gyrase Inhibitors Discovered through a Fluorescence-Based High-Throughput Screening Assay

Simultaneous Ca²⁺ Imaging and Optogenetic Stimulation of Cortical Astrocytes in Adult Murine Brain Slices

Mapping chemotherapeutic drug distribution in cancer cell spheroids using 2D-TOF-SIMS and LESA-TIMS-MS.  ANALYST.  145:7056-7062.

Identification of HMGA2 inhibitors by AlphaScreen-based ultra-high-throughput screening assays.  SCIENTIFIC REPORTS.  10.

A Novel Interaction of Translocator Protein 18 kDa (TSPO) with NADPH Oxidase in Microglia.  MOLECULAR NEUROBIOLOGY.  57:4467-4487.

Kinetic Study of DNA Topoisomerases by Supercoiling-Dependent Fluorescence Quenching.  ACS OMEGA.  4:18413-18422.

Tyrosyl-DNA Phosphodiesterase 1 and Topoisomerase I Activities as Predictive Indicators for Glioblastoma Susceptibility to Genotoxic Agents

Sab concentrations indicate chemotherapeutic susceptibility in ovarian cancer cell lines.  BIOCHEMICAL JOURNAL.  475:3471-3492.

STEM-18. THE c-Jun N-TERMINAL KINASE (JNK) IS A CRUCIAL COMPONENT OF MAINTENANCE IN GLIOBLASTOMA STEM-LIKE CELLS..  NEURO-ONCOLOGY.  20:vi247-vi247.

EXTH-09. TDP1/TOP1 RATIO AS A PREDICTIVE INDICATOR FOR THE RESPONSE OF GLIOBLASTOMA CANCER CELLS TO IRINOTECAN TREATMENT.  NEURO-ONCOLOGY.  19:vi74-vi75.

Sab is differentially expressed in the brain and affects neuronal activity.  BRAIN RESEARCH.  1670:76-85.

Sab mediates mitochondrial dysfunction involved in imatinib mesylate-induced cardiotoxicity.  TOXICOLOGY.  382:24-35.

Analysis of Chemotherapeutic Drug Delivery at the Single Cell Level Using 3D-MSI-TOF-SIMS.  JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY.  27:2033-2040.

Fluorescently labeled circular DNA molecules for DNA topology and topoisomerases.  SCIENTIFIC REPORTS.  6.

CBIO-07COMBINED BH3 AND METABOLIC PROFILING AS A METHOD TO DEFINE THERAPEUTIC RESPONSE AND RESISTANCE IN GRADE IV ASTROCYTOMAS.  NEURO-ONCOLOGY.  17:v56-v56.

CSIG-01Sab-MEDIATED SIGNALING INFLUENCES AEROBIC GLYCOLYSIS AND CHEMOSUSCEPTIBILITY IN HUMAN NEUROBLASTOMA CELLS.  NEURO-ONCOLOGY.  17:v66-v66.

Sub-chronic administration of LY294002 sensitizes cervical cancer cells to chemotherapy by enhancing mitochondrial JNK signaling.  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.  463:538-544.

A rapid and sensitive high-throughput screening method to identify compounds targeting protein-nucleic acids interactions.  NUCLEIC ACIDS RESEARCH.  43.

A trivalent approach for determining in vitro toxicology: Examination of oxime K027.  JOURNAL OF APPLIED TOXICOLOGY.  35:219-227.

A Small Molecule Bidentate-Binding Dual Inhibitor Probe of the LRRK2 and JNK Kinases

Inhibition of JNK Mitochondrial Localization and Signaling Is Protective against Ischemia/Reperfusion Injury in Rats

Blocking c-Jun N-terminal Kinase (JNK) Translocation to the Mitochondria Prevents 6-Hydroxydopamine-induced Toxicity in Vitro and in Vivo

Atmospheric Oxygen Inhibits Growth and Differentiation of Marrow-Derived Mouse Mesenchymal Stem Cells via a p53-Dependent Mechanism: Implications for Long-Term Culture Expansion

Selective Inhibition of Mitochondrial JNK Signaling Achieved Using Peptide Mimicry of the Sab Kinase Interacting Motif-1 (KIM1)

Mitochondrial c-Jun N-terminal Kinase (JNK) Signaling Initiates Physiological Changes Resulting in Amplification of Reactive Oxygen Species Generation

Small Molecule c-jun-N-Terminal Kinase Inhibitors Protect Dopaminergic Neurons in a Model of Parkinson's Disease.  ACS CHEMICAL NEUROSCIENCE.  2:198-206.

Quercetin, a fluorescent bioflavanoid, inhibits Trypanosoma brucei hexokinase 1

Glutamine Metabolism Is Essential for Human Cytomegalovirus Infection

Synthesis, Biological Evaluation, X-ray Structure, and Pharmacokinetics of Aminopyrimidine c-jun-N-terminal Kinase (JNK) Inhibitors.  JOURNAL OF MEDICINAL CHEMISTRY.  53:419-431.

Assembly of heterohexameric trypanosome hexokinases reveals that hexokinase 2 is a regulable enzyme

The anti-trypanosomal agent lonidamine inhibits Trypanosoma brucei hexokinase 1.  MOLECULAR AND BIOCHEMICAL PARASITOLOGY.  158:202-207.

Residues in an ATP binding domain influence sugar binding in a trypanosome hexokinase.  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.  365:420-425.

Activity of a second Trypanosoma brucei hexokinase is controlled by an 18-amino-acid C-terminal tail.  EUKARYOTIC CELL.  5:2014-2023.

Cognitive impact of exposure to airborne particles captured by brain imaging.  29-45.

Assessment of Mitochondrial Stress in Neurons: Proximity Ligation Assays to Detect Recruitment of Stress-Responsive Proteins to Mitochondria.  87-118.

THE c-Jun N-TERMINAL KINASE (JNK) IS A CRUCIAL COMPONENT OF MAINTENANCE IN GLIOBLASTOMA STEM-LIKE CELLS..  NEURO-ONCOLOGY. 247-247.

TDP1/TOP1 RATIO AS A PREDICTIVE INDICATOR FOR THE RESPONSE OF GLIOBLASTOMA CANCER CELLS TO IRINOTECAN TREATMENT.  NEURO-ONCOLOGY. 74-75.

A novel splice variant of Sab (SH3BP5) alters mitochondrial physiology..  MOLECULAR BIOLOGY OF THE CELL.

Alterations in outer mitochondrial signaling promote organelle and neuronal dysfunction..  MOLECULAR BIOLOGY OF THE CELL.

Combined BH3 and Metabolic Profiling as a Method to Define Therapeutic Response and Resistance in Grade IV Astrocytomas.  FASEB JOURNAL.

Sab-mediated signaling regulates mitochondrial fission.  FASEB JOURNAL.

Tight Binding of Natural Polyphenols to the Intrinsically Disordered Mammalian High Mobility Group Protein At-Hook 2.  BIOPHYSICAL JOURNAL. 482A-482A.

EXTH-09. TDP1/TOP1 RATIO AS A PREDICTIVE INDICATOR FOR THE RESPONSE OF GLIOBLASTOMA CANCER CELLS TO IRINOTECAN TREATMENT.  NEURO-ONCOLOGY. vi74-vi75.

Identification of novel chemotherapies targeting mitochondrial-cell communication.  FASEB JOURNAL.

Synthesis, Biological Evaluation, X-ray Structure, and Pharmacokinetics of Aminopyrimidine c-jun-N-terminal Kinase (JNK) Inhibitors (vol 53, pg 419, 2010).  JOURNAL OF MEDICINAL CHEMISTRY. 1882-1882.

Physiological JNK3 Concentrations Are Higher in Motor-related and Disease-implicated Brain Regions of C57BL6/J Mice.

Suramin potently inhibits binding of the mammalian high mobility group protein AT-hook 2 to DNA

Tyrosyl-DNA phosphodiesterase 1 and topoisomerase I activities as predictive indicators for Glioblastoma susceptibility to genotoxic agents

Phosphoregulation on mitochondria: Integration of cell and organelle responses.  837-858.