Novel and Structurally Diversified Bacterial DNA Gyrase Inhibitors Discovered through a Fluorescence-Based High-Throughput Screening Assay Article

Alfonso, Eddy E, Deng, Zifang, Boaretto, Daniel et al. (2022). Novel and Structurally Diversified Bacterial DNA Gyrase Inhibitors Discovered through a Fluorescence-Based High-Throughput Screening Assay . 5(10), 932-944. 10.1021/acsptsci.2c00113

cited authors

  • Alfonso, Eddy E; Deng, Zifang; Boaretto, Daniel; Hood, Becky L; Vasile, Stefan; Smith, Layton H; Chambers, Jeremy W; Chapagain, Prem; Leng, Fenfei

authors

publication date

  • September 2, 2022

keywords

  • CLEAVAGE
  • COMPLEXES
  • Chemistry, Medicinal
  • DESIGN
  • DNA gyrase
  • DNA topoisomerase
  • DOUBLE-STRAND BREAKS
  • LESSONS
  • Life Sciences & Biomedicine
  • MECHANISMS
  • Pharmacology & Pharmacy
  • RECEPTOR
  • RESISTANCE
  • SUPERHELICAL TURNS
  • Science & Technology
  • TOPOISOMERASE-II
  • gyrase inhibitor
  • gyrase poison
  • high-throughput screening assay
  • supercoiling-dependent fluorescence quenching assay

Digital Object Identifier (DOI)

publisher

  • AMER CHEMICAL SOC

start page

  • 932

end page

  • 944

volume

  • 5

issue

  • 10