Nucleic Acids Research (NAR)

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Nucleic Acids Research (NAR) Journal

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Synthesizing supercoiled circular DNA molecules in vitro. 53. 2025
Direct histone proteoform profiling of the unannotated, endangered coral Acropora cervicornis. 53. 2025
Inhibition of HMGA2 binding to AT-rich DNA by its negatively charged C-terminus. 53. 2025
Variable patterns of retrotransposition in different HeLa strains provide mechanistic insights into SINE RNA mobilization processes. 52:7761-7779. 2024
RNA-guided DNA base damage repair via DNA polymerase-mediated nick translation. 51:166-181. 2023
The interaction between transport-segment DNA and topoisomerase IA-crystal structure of MtbTOP1 in complex with both G- and T-segments. 51:349-364. 2023
AT-hook peptides bind the major and minor groove of AT-rich DNA duplexes. 50:2431-2439. 2022
Negative DNA supercoiling makes protein-mediated looping deterministic and ergodic within the bacterial doubling time. 49:11550-11559. 2021
The Cryo-EM structure of AAV2 Rep68 in complex with ssDNA reveals a malleable AAA+ machine that can switch between oligomeric states. 48:12983-12999. 2020
DNA and RNA editing without sequence limitation using the flap endonuclease 1 guided by hairpin DNA probes. 48. 2020
Label-free profiling of DNA aptamer-small molecule binding using T5 exonuclease. 48. 2020
Mechanistic insights from structure of Mycobacterium smegmatis topoisomerase I with ssDNA bound to both N- and C-terminal domains. 48:4448-4462. 2020
coMethDMR: accurate identification of co-methylated and differentially methylated regions in epigenome-wide association studies with continuous phenotypes. 47. 2019
In vitro isolation of class-specific oligonucleotide-based small-molecule receptors. 47. 2019
RaftProt V2: understanding membrane microdomain function through lipid raft proteomes. 47:D459-D463. 2019
The deoxyribose phosphate lyase of DNA polymerase β suppresses a processive DNA synthesis to prevent trinucleotide repeat instability. 46:8940-8952. 2018
Investigating mycobacterial topoisomerase I mechanism from the analysis of metal and DNA substrate interactions at the active site. 46:7296-7308. 2018
Introducing structure-switching functionality into small-molecule-binding aptamers via nuclease-directed truncation. 46. 2018
Protein-mediated loops in supercoiled DNA create large topological domains. 46:4417-4424. 2018
In vitro isolation of small-molecule-binding aptamers with intrinsic dye-displacement functionality. 46. 2018
Protein-mediated looping of DNA under tension requires supercoiling. 46:2370-2379. 2018
Deacetylation of topoisomerase I is an important physiological function of E-coli CobB. 45:5349-5358. 2017
MicroRNA-202 maintains spermatogonial stem cells by inhibiting cell cycle regulators and RNA binding proteins. 45:4142-4157. 2017
RNA topoisomerase is prevalent in all domains of life and associates with polyribosomes in animals. 44:6335-6349. 2016
Structural basis for suppression of hypernegative DNA supercoiling by E-coli topoisomerase I. 43. 2015
AP endonuclease 1 prevents trinucleotide repeat expansion via a novel mechanism during base excision repair. 43:5948-5960. 2015
A rapid and sensitive high-throughput screening method to identify compounds targeting protein-nucleic acids interactions. 43. 2015
A 5′, 8-cyclo-2′-deoxypurine lesion induces trinucleotide repeat deletion via a unique lesion bypass by DNA polymerase β. 42:13749-13763. 2014
The Werner syndrome protein limits the error-prone 8-oxo-dG lesion bypass activity of human DNA polymerase kappa. 42:12027-12040. 2014
Base excision repair of oxidative DNA damage coupled with removal of a CAG repeat hairpin attenuates trinucleotide repeat expansion. 42:3675-3691. 2014
Human Rev1 polymerase disrupts G-quadruplex DNA. 42:3272-3285. 2014
Deep sequencing analyses expands the Pseudomonas aeruginosa AmpR regulon to include small RNA-mediated regulation of iron acquisition, heat shock and oxidative stress response. 42:979-998. 2014
Trinucleotide repeat deletion via a unique hairpin bypass by DNA polymerase β and alternate flap cleavage by flap endonuclease 1. 41:1684-1697. 2013
A dynamic and intricate regulatory network determines Pseudomonas aeruginosa virulence. 41:1-20. 2013
Selection is more intelligent than design: improving the affinity of a bivalent ligand through directed evolution. 40:11777-11783. 2012
Residues of E-coli topoisomerase I conserved for interaction with a specific cytosine base to facilitate DNA cleavage. 40:9233-9243. 2012
Postnatal development- and age-related changes in DNA-methylation patterns in the human genome. 40:6477-6494. 2012
DNA linking number change induced by sequence-specific DNA-binding proteins. 38:3643-3654. 2010
H2A.Bbd: an X-chromosome-encoded histone involved in mammalian spermiogenesis. 38:1780-1789. 2010
Bacterial topoisomerase I as a target for discovery of antibacterial compounds. 37:731-737. 2009
Inhibition of Mg²⁺ binding and DNA religation by bacterial topoisomerase I via introduction of an additional positive charge into the active site region. 36:4788-4796. 2008
Mutation adjacent to the active site tyrosine can enhance DNA cleavage and cell killing by the TOPRIM Gly to Ser mutant of bacterial topoisomerase I. 36:1017-1025. 2008
New Onto-Tools: Promoter-Express, nsSNPCounter and Onto-Translate. 34:W626-W631. 2006
Experimental and computational investigations of Ser10 and Lys13 in the binding and cleavage of DNA substrates by Escherichia coli DNA topoisomerase I. 34:1785-1797. 2006
An RNA polymerase II construct synthesizes short-hairpin RNA with a quantitative indicator and mediates highly efficient RNAi. 33:1-8. 2005
Energetics of echinomycin binding to DNA. 31:6191-6197. 2003
DSSPcont: continuous secondary structure assignments for proteins. 31:3293-3295. 2003
NLSdb: database of nuclear localization signals. 31:397-399. 2003
PEP: Predictions for Entire Proteomes. 31:410-413. 2003
IDENTIFICATION OF THE METALLOREGULATORY ELEMENT OF THE PLASMID-ENCODED ARSENICAL RESISTANCE OPERON. 18:619-624. 1990
IMPROVED OLIGONUCLEOTIDE SITE-DIRECTED MUTAGENESIS USING M13 VECTORS. 13:4431-4443. 1985
REGULATION OF THE ESCHERICHIA-COLI DNA TOPOISOMERASE-I GENE BY DNA SUPERCOILING. 13:4751-4763. 1985
MECHANISTIC STUDY OF ESCHERICHIA-COLI DNA TOPOISOMERASE-I - CLEAVAGE OF OLIGONUCLEOTIDES. 11:8691-8701. 1983
On the cooperative and noncooperative binding of ethidium to DNA. 10:8211-8223. 1982
DROSOPHILA-TOPOISOMERASE-I - ISOLATION, PURIFICATION AND CHARACTERIZATION. 10:6945-6955. 1982
Equilibrium binding of carcinogens and antitumor antibiotics to DNA: Site selectivity, cooperativity, allosterism. 9:3175-3186. 1981
Inhibition of HMGA2 binding to AT-rich DNA by its negatively charged C-terminus ( vol 53, gkaf035, 2025) 2025
SEPPA 3.0-enhanced spatial epitope prediction enabling glycoprotein antigens. 2019
Re-usable DNA template for the polymerase chain reaction. 1997

International Standard Serial Number (ISSN)

0305-1048

Electronic International Standard Serial Number (EISSN)

1362-4962