Fierst, Janna
- Associate Professor, Biological Sciences , College of Arts, Sciences & Education
Overview
overview
- Research in my lab focuses on understanding the rules of genome evolution. We study how life is organized, structured, and changes and how we can use theory, computational models and bioinformatic analyses to understand it.
Publications
selected scholarly works & creative activities
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Article
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2025Investigating the differential microRNAs expression in young and aged Drosophila melanogaster following Flock House Virus infection. Virulence. 16.Full Text via DOI: 10.1080/21505594.2025.2549497 Web of Science: 001559413400001
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2025Unearthing soil biodiversity through collaborative genomic research and education.. Nature Genetics.Full Text via DOI: 10.1038/s41588-025-02442-5
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2025The eukaryotic horizontal gene transfer dataset a compendium.. bioRxiv.Full Text via DOI: 10.1101/2025.11.05.686818
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2024Identifying transgene insertions in Caenorhabditis elegans genomes with Oxford Nanopore sequencing. PeerJ. 12.Full Text via DOI: 10.7717/peerj.18100 Web of Science: 001316501400008
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2023Acetylenotrophic and Diazotrophic Bradyrhizobium sp. Strain I71 from Trichloroethylene-Contaminated Soils. ARPHA Conference Abstracts. 6:e109201.Full Text via DOI: 10.3897/aca.6.e109201
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2023Genome Size Changes by Duplication, Divergence, and Insertion in Caenorhabditis Worms. Molecular Biology and Evolution (MBE). 40.Full Text via DOI: 10.1093/molbev/msad039 Web of Science: 000950310700004
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2023Dauer fate in a Caenorhabditis elegans Boolean network model. PeerJ. 11.Full Text via DOI: 10.7717/peerj.14713 Web of Science: 000925361000003
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2022Acetylenotrophic and Diazotrophic Bradyrhizobium sp. Strain I71 from TCE-Contaminated Soils. Applied and Environmental Microbiology. 88.Full Text via DOI: 10.1128/aem.01219-22 Web of Science: 000876970000001
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2022Slow Recovery from Inbreeding Depression Generated by the Complex Genetic Architecture of Segregating Deleterious Mutations. Molecular Biology and Evolution (MBE). 39.Full Text via DOI: 10.1093/molbev/msab330 Web of Science: 000771141500012
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2022Complete Genome Sequence of Rhodococcus opacus Strain MoAcy1 (DSM 44186), an Aerobic Acetylenotroph Isolated from Soil. Microbiology Resource Announcements. 11.Full Text via DOI: 10.1128/MRA.00814-21 Web of Science: 000746032300029
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2021Optimizing experimental design for genome sequencing and assembly with Oxford Nanopore Technologies. Gigabyte. 2021.Full Text via DOI: 10.46471/gigabyte.27
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2021Age-dependent impairment of disease tolerance is associated with a robust transcriptional response following RNA virus infection in Drosophila. G3: Genes, Genomes, Genetics. 11.Full Text via DOI: 10.1093/g3journal/jkab116 Web of Science: 000735821500011
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2021Complex pleiotropic genetic architecture of evolved heat stress and oxidative stress resistance in the nematode Caenorhabditis remanei. G3: Genes, Genomes, Genetics. 11.Full Text via DOI: 10.1093/g3journal/jkab045 Web of Science: 000651852100011
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2021Syntrophotalea acetylenivorans sp. nov., a diazotrophic, acetylenotrophic anaerobe isolated from intertidal sediments. International Journal of Systematic and Evolutionary Microbiology. 71.Full Text via DOI: 10.1099/ijsem.0.004698 Web of Science: 000639142700023
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2020Caenorhabditis elegansdauers vary recovery in response to bacteria from natural habitat. Ecology and Evolution. 10:9886-9895.Full Text via DOI: 10.1002/ece3.6646 Web of Science: 000562028100001
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2020De NovoGenome Assemblies for Three North American Bumble Bee Species:Bombus bifarius,Bombus vancouverensis, andBombus vosnesenskii. G3: Genes, Genomes, Genetics. 10:2585-2592.Full Text via DOI: 10.1534/g3.120.401437 Web of Science: 000560448200003
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2020Environmental stress maintains trioecy in nematode worms. Evolution. 74:518-527.Full Text via DOI: 10.1111/evo.13932 Web of Science: 000512354500001
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2017Decontaminating eukaryotic genome assemblies with machine learning. BMC Bioinformatics. 18.Full Text via DOI: 10.1186/s12859-017-1941-0 Web of Science: 000416904100001
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2017Detection of Diazotrophy in the Acetylene-Fermenting Anaerobe Pelobacter sp Strain SFB93. Applied and Environmental Microbiology. 83.Full Text via DOI: 10.1128/AEM.01198-17 Web of Science: 000408259000026
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2017Complete Genome Sequence of the Acetylene-Fermenting Pelobacter sp. Strain SFB93. Microbiology Resource Announcements. 5.Full Text via DOI: 10.1128/genomeA.01573-16 Web of Science: 000460679700013
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2017Complete Genome Sequences of Two Acetylene-Fermenting Pelobacter acetylenicus Strains. Microbiology Resource Announcements. 5.Full Text via DOI: 10.1128/genomeA.01572-16 Web of Science: 000460679700012
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2017Metagenome-Assembled Draft Genome Sequence of a Novel Microbial Stenotrophomonas maltophilia Strain Isolated from Caenorhabditis remanei Tissue. Microbiology Resource Announcements. 5.Full Text via DOI: 10.1128/genomeA.01646-16 Web of Science: 000460681200024
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2016Rebalancing redox to improve biobutanol production by clostridium tyrobutyricum. Bioengineering. 3.Full Text via DOI: 10.3390/bioengineering3010002
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2015Reproductive Mode and the Evolution of Genome Size and Structure in Caenorhabditis Nematodes. PLoS Genetics. 11.Full Text via DOI: 10.1371/journal.pgen.1005323 Web of Science: 000357341600048
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2015Modeling the Evolution of Complex Genetic Systems: The Gene Network Family Tree. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution. 324:1-12.Full Text via DOI: 10.1002/jez.b.22597 Web of Science: 000346267300001
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2013Female mating preferences determine system-level evolution in a gene network model. Genetica. 141:157-170.Full Text via DOI: 10.1007/s10709-013-9714-9 Web of Science: 000323902200003
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2013PROPERTIES OF SPONTANEOUS MUTATIONAL VARIANCE AND COVARIANCE FOR WING SIZE AND SHAPE IN DROSOPHILA MELANOGASTER. Evolution. 67:1116-1130.Full Text via DOI: 10.1111/j.1558-5646.2012.01838.x Web of Science: 000317133800016
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2012Variance in Epistasis Links Gene Regulation and Evolutionary Rate in the Yeast Genetic Interaction Network. Genome Biology and Evolution. 4:1080-1087.Full Text via DOI: 10.1093/gbe/evs083 Web of Science: 000313215500002
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2011A history of phenotypic plasticity accelerates adaptation to a new environment. Journal of Evolutionary Biology. 24:1992-2001.Full Text via DOI: 10.1111/j.1420-9101.2011.02333.x Web of Science: 000293910500016
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2011Sexual Dimorphism Increases Evolvability in a Genetic Regulatory Network. Evolutionary Biology. 38:52-67.Full Text via DOI: 10.1007/s11692-010-9103-6
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2010Spatial distribution and reproductive phenology of sexual and asexual Mastocarpus papillatus (Rhodophyta). Phycologia. 49:274-282.Full Text via DOI: 10.2216/PH09-41.1 Web of Science: 000277475400007
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2010GENETIC ARCHITECTURE AND POSTZYGOTIC REPRODUCTIVE ISOLATION: EVOLUTION OF BATESON-DOBZHANSKY-MULLER INCOMPATIBILITIES IN A POLYGENIC MODEL. Evolution. 64:675-693.Full Text via DOI: 10.1111/j.1558-5646.2009.00861.x Web of Science: 000274713800006
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2009SEXUAL SELECTION ACCELERATES THE ELIMINATION OF A DELETERIOUS MUTANT IN DROSOPHILA MELANOGASTER. Evolution. 63:324-333.Full Text via DOI: 10.1111/j.1558-5646.2008.00551.x Web of Science: 000263254000003
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2005Fertilization success can drive patterns of phase dominance in complex life histories. Journal of Phycology. 41:238-249.Full Text via DOI: 10.1111/j.1529-8817.2005.04024.x
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2002Spatial and Temporal Distribution of Life History Variants in the Red Alga, Mastocarpus Papillatus. Journal of Phycology. 38:9-9.Full Text via DOI: 10.1046/j.1529-8817.38.s1.26.x
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Other Scholarly Work
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2024Regulatory logic and transposable element dynamics in nematode worm genomesFull Text via DOI: 10.1101/2024.09.15.613132
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2020Genome Evolution: On the Road to Parasitism. Current Biology. R272-R274.Full Text via DOI: 10.1016/j.cub.2020.01.088 Web of Science: 000522553700015
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2015Erratum to: Reproductive Mode and the Evolution of Genome Size and Structure in Caenorhabditis Nematodes (PLoS Genet, (2015), 11, 9). PLoS Genetics.Full Text via DOI: 10.1371/journal.pgen.1005497
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Preprint
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2022Dauer fate in aCaenorhabditis elegansBoolean network modelFull Text via DOI: 10.1101/2022.08.18.504430
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2021Optimizing experimental design for genome sequencing and assembly with Oxford Nanopore TechnologiesFull Text via DOI: 10.1101/2020.05.05.079327 Web of Science: 001401603300001
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Review
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2025Phylogenetic comparative methods for studying adaptation: the adaptation-inertia framework. Journal of Evolutionary Biology.Full Text via DOI: 10.1093/jeb/voaf113 Web of Science: 001605992900001
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2018Acetylenotrophy: a hidden but ubiquitous microbial metabolism?. FEMS Microbiology Ecology.Full Text via DOI: 10.1093/femsec/fiy103 Web of Science: 000441198800001
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2015Using linkage maps to correct and scaffold de novo genome assemblies: methods, challenges, and computational tools. Frontiers in Genetics.Full Text via DOI: 10.3389/fgene.2015.00220 Web of Science: 000359647500001
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REVIEW OF THE DAUER HYPOTHESIS: WHAT NON-PARASITIC SPECIES CAN TELL US ABOUT THE EVOLUTION OF PARASITISM. Journal of Parasitology. 717-725.Full Text via DOI: 10.1645/21-40 Web of Science: 000696462900002
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Research
principal investigator on
- Structural variants and the locus of evolution awarded by General Medical Sciences 2022 - 2027
- Mechanisms underlying aged host-virus interactions awarded by National Institutes of Health 2024 - 2026
- CAREER: Reproductive mode and horizontal gene transfer in nematode worms: Training early career researchers in computational evolutionary biology awarded by National Science Foundation 2022 - 2026
- Tangy Citrus awarded by DEFENSEWERX 2025 - 2026
- Understanding the Rules of Life: Epigenetics 2: Collaborative research: Bumble bee cold tolerance across elevations- From epigenotype to phenotype across space, time, and levels of biological organization awarded by National Science Foundation 2022 - 2025
Contact
full name
- Janna Fierst
