Deoraj, Alok

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Deoraj, Alok Graduate Faculty

Positions

Teaching Professor, Environmental Health Sciences , Robert Stempel College of Public Health and Social Work

adeoraj@fiu.edu

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biography

Dr. Alok Deoraj has extensive teaching, research and management experience in academic and industry settings. His current primary focus is on teaching undergraduate, graduate and PhD students. Dr. Deoraj conducts research in the area of environmental toxicology to investigate the influence of complex environmental exposures on the neuroendocrine regulation (e.g., via Kisseptin, GABA and other neuropeptides) of Gonadotropin-releasing Hormone-II (GnRH-II) release and its downstream signaling on the timing of the onset of the puberty/adolescence. He is interested in finding whether timing of puberty is a risk factor for reproductive cancer and/or neurodegenerative diseases. His research may lead to identify exposome(s), environmental and epigenetic biomarkers which can be applied to conduct environmental health risk assessment for reproductive aging/cancer and neurodegenerative disorders.

research interests

Environmental Toxicology

selected scholarly works & creative activities

Article
- 2023
  
  Inhibitor of DNA Binding Protein 3 (ID3) and Nuclear Respiratory Factor 1 (NRF1) Mediated Transcriptional Gene Signatures are Associated with the Severity of Cerebral Amyloid Angiopathy. MOLECULAR NEUROBIOLOGY.
  Full Text via DOI: 10.1007/s12035-023-03541-2 Web of Science: 001062744100002
- 2023
  
  Endocrine Disrupting Chemicals Influence Hub Genes Associated with Aggressive Prostate Cancer
  Full Text via DOI: 10.3390/ijms24043191 Web of Science: 000939034100001
- 2022
  
  Brain infiltration of breast cancer stem cells is facilitated by paracrine signaling by inhibitor of differentiation 3 to nuclear respiratory factor 1. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY. 148:2881-2891.
  Full Text via DOI: 10.1007/s00432-022-04026-w Web of Science: 000808418200001
- 2022
  
  Nuclear respiratory factor 1 transcriptomic signatures as prognostic indicators of recurring aggressive mesenchymal glioblastoma and resistance to therapy in White American females. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY. 148:1641-1682.
  Full Text via DOI: 10.1007/s00432-022-03987-2 Web of Science: 000784837600002
- 2022
  
  Abstract 1442: Discovery of recurrence and prognosis associated genes in prostate cancer. CANCER RESEARCH. 82:1442-1442.
  Full Text via DOI: 10.1158/1538-7445.am2022-1442
- 2022
  
  Abstract 779: A NRF1-driven JRK-mediated β-catenin transcriptional activity contributes to the aggressive growth of ovarian cancer. CANCER RESEARCH. 82:779-779.
  Full Text via DOI: 10.1158/1538-7445.am2022-779
- 2022
  
  Environmental Phenol and Paraben Exposure Risks and Their Potential Influence on the Gene Expression Involved in the Prognosis of Prostate Cancer
  Full Text via DOI: 10.3390/ijms23073679 Web of Science: 000781204300001
- 2017
  
  Environmental estrogen-like endocrine disrupting chemicals and breast cancer. MOLECULAR AND CELLULAR ENDOCRINOLOGY. 457:89-102.
  Full Text via DOI: 10.1016/j.mce.2016.10.003 Web of Science: 000413128000011
- 2016
  
  Use of Bioinformatics in Revealing the Identity of Nature’s Products with Minimum Genetic Variation: The Sibling Species
  Full Text via DOI: 10.1201/b19969-6
- 2016
  
  Assessing plant growth, water quality and economic effects from application of a plant-based aquafeed in a recirculating aquaponic system. AQUACULTURE INTERNATIONAL. 24:415-427.
  Full Text via DOI: 10.1007/s10499-015-9934-3 Web of Science: 000372553000030
- 2016
  
  Association between Exposure to Estrogenic Endocrine Disruptors - Polychlorinated Biphenyls, Phthalates, and Bisphenol A and Gynecologic Cancers- Cervical, Ovarian, Uterine Cancers
  Full Text via DOI: 10.4172/2157-2518.1000275
- 2015
  
  Integrated Bioinformatics, Environmental Epidemiologic and Genomic Approaches to Identify Environmental and Molecular Links between Endometriosis and Breast Cancer
  Full Text via DOI: 10.3390/ijms161025285 Web of Science: 000364232100114
- 2015
  
  Redox signalling to nuclear regulatory proteins by reactive oxygen species contributes to oestrogen-induced growth of breast cancer cells. BRITISH JOURNAL OF CANCER. 112:1687-1702.
  Full Text via DOI: 10.1038/bjc.2014.586 Web of Science: 000354376500009
- 2003
  
  Effects of controlled delivery and acute injections of LHRHa on bullseye puffer fish (Sphoeroides annulatus) spawning. AQUACULTURE. 218:625-635.
  Full Text via DOI: 10.1016/S0044-8486(02)00299-5 Web of Science: 000181376100050
- 2001
  
  Recombinant perciform GnRH-R activates different signaling pathways in fish and mammalian heterologous cell lines. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY. 129:375-380.
  Full Text via DOI: 10.1016/S1096-4959(01)00325-6 Web of Science: 000169374800021
- 2000
  
  Characterization of a pituitary GnRH-receptor from a perciform fish, Morone saxatilis: functional expression in a fish cell line. MOLECULAR AND CELLULAR ENDOCRINOLOGY. 168:65-75.
  Full Text via DOI: 10.1016/S0303-7207(00)00317-8 Web of Science: 000165062000007
- 2000
  
  Cloning and functional expression of a thyrotropin receptor from the gonads of a vertebrate (bony fish): potential thyroid-independent role for thyrotropin in reproduction. MOLECULAR AND CELLULAR ENDOCRINOLOGY. 167:1-9.
  Full Text via DOI: 10.1016/S0303-7207(00)00304-X Web of Science: 000089571600001
- 2000
  
  In vivo activity of salmon gonadotropin releasing hormone (GnRH), its agonists with structural modifications at positions 6 and 9, mammalian GnRH agonists and native cGnRH-II on the spawning of an Indian catfish. AQUACULTURE INTERNATIONAL. 7:383-392.
  Full Text via DOI: 10.1023/A:1009262230465 Web of Science: 000085704500002
- 1998
  
  Multiple GnRHs present in a teleost species are encoded by separate genes: analysis of the sbGnRH and cGnRH-II genes from the striped bass, Morone saxatilis
  Full Text via DOI: 10.1677/jme.0.0210277 Web of Science: 000077920600004
- 1998
  
  GnRH analog stimulates gonadotropin II gene expression in maturing sockeye salmon
  Full Text via DOI: 10.2108/zsj.15.761 Web of Science: 000077864200021
- 1998
  
  Gonadotropin-releasing hormone analog and sex steroids shorten homing duration of sockeye salmon in Lake Shikotsu
  Full Text via DOI: 10.2108/zsj.15.767 Web of Science: 000077864200022
- 1998
  
  Multiple induced spawnings of the Indian catfish Heteropneustes fossilis (Bloch) within a prolonged spawning season
  Full Text via DOI: 10.1111/j.1749-7345.1998.tb00985.x Web of Science: 000074324100014
- 1997
  
  Binding of factor VIIa to tissue factor induces alterations in gene expression in human fibroblast cells: Up-regulation of poly(A) polymerase. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 94:12598-12603.
  Full Text via DOI: 10.1073/pnas.94.23.12598 Web of Science: A1997YF39300064
- 1997
  
  Effect of D-Lys(6) salmon sGnRH alone and in combination with domperidone on the spawning of common carp during the late spawning season. AQUACULTURE INTERNATIONAL. 5:369-374.
  Full Text via DOI: 10.1023/A:1018320325162 Web of Science: A1997XK86800008
- 1996
  
  Translational fusion of heat labile enterotoxin chain B and beta-subunit of human chorionic gonadotropin: Periplasmic expression in Escherichia coli and its immunogenicity. FEBS LETTERS. 387:23-26.
  Full Text via DOI: 10.1016/0014-5793(96)00428-0 Web of Science: A1996UP83800005
- 1994
  
  PRECOCIOUS OVARIAN RECRUDESCENCE AND INDUCED OFF-SEASON SPAWNING OF HETEROPNEUSTES-FOSSILIS BY D-LYS6 SALMON GONADOTROPIN-RELEASING-HORMONE ANALOG (SGNRH-A). JOURNAL OF FISH BIOLOGY. 45:909-915.
  Web of Science: A1994PY01000001
- 1993
  
  INDUCED SPAWNING OF CATFISH, HETEROPNEUSTES-FOSSILIS (BLOCH), USING D-LYS(6) SALMON GONADOTROPIN-RELEASING-HORMONE ANALOG. AQUACULTURE. 115:159-167.
  Full Text via DOI: 10.1016/0044-8486(93)90366-7 Web of Science: A1993LU21900014
- 1989
  
  Gene transfer in fish embryos for increased productivity
  Full Text via DOI: 10.1016/0093-691X(89)90575-X
Book Chapter
- 2016
  
  Integrated Bioinformatics, Biostatistics, and Molecular Epidemiologic Approaches to Study How the Environment and Genes Work Together to Influence the Development of Complex Chronic Diseases. 151-191.
  Web of Science: 000468317900006
- 2010
  
  Approaches to Identify Environmental and Epigenomic Components or Covariates of Cancer and Disease Susceptibility. 197-219.
  Full Text via DOI: 10.1007/978-1-4419-6752-7_8 Web of Science: 000282535900008
Conference
- 2022
  
  A NRF1-driven JRK-mediated β-catenin transcriptional activity contributes to the aggressive growth of ovarian cancer. CANCER RESEARCH.
  Web of Science: 000892509506088
- 2018
  
  Exosomal ID3 is pro-metastatic through guiding NRF1-induced breast cancer stem cells across the blood-brain-barrier. CANCER RESEARCH.
  Full Text via DOI: 10.1158/1538-7445.AM2018-1128 Web of Science: 000468818903101
- 2015
  
  Phosphodeficient NRF1 mutant suppresses the susceptibility of the breast epithelial cells to develop tumors when exposed to estrogen - a major breast cancer risk factor. CANCER RESEARCH.
  Full Text via DOI: 10.1158/1538-7445.AM2015-4559 Web of Science: 000371597104187
Other Scholarly Work
- 2023
  
  Checkpoint Kinase I, Cyclin E1, and Exonuclease I genes play role in the survival of lung adenocarcinoma patients. CANCER RESEARCH.
  Full Text via DOI: 10.1158/1538-7445.AM2023-3158 Web of Science: 001008499100135
- 2023
  
  ID3 controlled dynamic Pyk2 localization is important for the mobility of cancer stem cells. CANCER RESEARCH.
  Full Text via DOI: 10.1158/1538-7445.AM2023-1278 Web of Science: 001008193602212
- 2016
  
  Association between serum concentrations of polychlorinated biphenyls (PCBs) and increased risk of breast cancer among US women. CANCER RESEARCH.
  Full Text via DOI: 10.1158/1538-7445.AM2016-3433 Web of Science: 000389940604187
- 2010
  
  Differential role of estrogen receptor positive NRF1(High) and NRF1(Low) cells in breast cancer development and progression. NEW BIOTECHNOLOGY. S25-S25.
  Full Text via DOI: 10.1016/j.nbt.2010.01.021 Web of Science: 000209825000061
Preprint
- 2022
  
  Brain infiltration of breast cancer stem cells is facilitated by paracrine signaling by inhibitor of differentiation 3 to nuclear respiratory factor 1
  Full Text via DOI: 10.21203/rs.3.rs-1443283/v1
- WITHDRAWN: Assessment of Remediation Through Measuring Nuclear Respiratory Factor 1 (nrf1) Environmental Stressor Transcriptomic Gene Signatures
  Full Text via DOI: 10.1101/2024.02.21.581481
Review
- 2020
  
  The gut microbiome and neuropsychiatric disorders: implications for attention deficit hyperactivity disorder (ADHD). JOURNAL OF MEDICAL MICROBIOLOGY. 14-24.
  Full Text via DOI: 10.1099/jmm.0.001112 Web of Science: 000518384100003
- 2011
  
  Estrogen-induced reactive oxygen species-mediated signalings contribute to breast cancer. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER. 115-133.
  Full Text via DOI: 10.1016/j.bbcan.2010.10.005 Web of Science: 000287124400009

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full name

Alok Deoraj

ORCID iD

https://orcid.org/0000-0002-3725-3971 (confirmed)

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