FIU Discovery

Design of gp120 HIV-1 entry inhibitors by scaffold hopping via isosteric replacements.  European Journal of Medicinal Chemistry.  224.

Synthesis of Vanadium Oxo Alkylidene Complex and Its Reactivity in Ring-Closing Olefin Metathesis Reactions.  Organometallics.  40:2939-2944.

Ring-Closing Olefin Metathesis Catalyzed by Well-Defined Vanadium Alkylidene Complexes.  Chemistry - A European Journal.  27:4578-4582.

Design, synthesis, and antiviral activity of a series of CD4-mimetic small-molecule HIV-1 entry inhibitors.  Bioorganic and Medicinal Chemistry.  32.

Stereospecific Ring-Opening Metathesis Polymerization of Norbornene Catalyzed by Iron Complexes.  Angewandte Chemie International Edition.  60:2934-2938.

Stereospecific Ring‐Opening Metathesis Polymerization of Norbornene Catalyzed by Iron Complexes.  Angewandte Chemie International Edition.  133:2970-2974.

Preclinical Optimization of gp120 Entry Antagonists as anti-HIV-1 Agents with Improved Cytotoxicity and ADME Properties through Rational Design, Synthesis, and Antiviral Evaluation.  Journal of Medicinal Chemistry.  63:1724-1749.

Synthesis, Antiviral Activity, and Structure-Activity Relationship of 1,3-Benzodioxolyl Pyrrole-Based Entry Inhibitors Targeting the Phe43 Cavity in HIV-1 gp120.  ChemMedChem.  13:2332-2348.

Structure-based lead optimization to improve antiviral potency and ADMET properties of phenyl-1H-pyrrole-carboxamide entry inhibitors targeted to HIV-1 gp120.  European Journal of Medicinal Chemistry.  154:367-391.

Guanidine-Containing Phenyl-Pyrrole Compounds as Probes for Generating HIV Entry Inhibitors Targeted to gp120.  ChemistrySelect.  3:6450-6453.

A Small-Molecule Inhibitor of Prion Replication and Mutant Prion Protein Toxicity.  ChemMedChem.  12:1286-1292.

Synthesis of 5-Arylpyrrole-2-carboxylic Acids as Key Intermediates for NBD Series HIV-1 Entry Inhibitors.  Synthesis.  49:3692-3699.

Synthesis, Antiviral Potency, in Vitro ADMET, and X-ray Structure of Potent CD4 Mimics as Entry Inhibitors That Target the Phe43 Cavity of HIV-1 gp120.  Journal of Medicinal Chemistry.  60:3124-3153.

Design, synthesis and evaluation of small molecule CD4-mimics as entry inhibitors possessing broad spectrum anti-HIV-1 activity.  Bioorganic and Medicinal Chemistry.  24:5988-6003.

Bicyclic octahydrocyclohepta[b]pyrrol-4(1H)one derivatives as novel selective anti-hepatitis C virus agents.  European Journal of Medicinal Chemistry.  122:319-325.

Fragment-Based Discovery of 5-Arylisatin-Based Inhibitors of Matrix Metalloproteinases 2 and 13.  ChemMedChem.  11:1892-1898.

ChemInform Abstract: Oxidative Dearomatization of 4,5,6,7‐Tetrahydro‐1H‐indoles Obtained by Metal‐ and Solvent‐Free Thermal 5‐endo‐dig Cyclization: The Route to Erythrina and Lycorine Alkaloids..  ChemInform.  47:no-no.

Oxidative Dearomatization of 4,5,6,7-Tetrahydro-1H-indoles Obtained by Metal- and Solvent-Free Thermal 5-endo-dig Cyclization: The Route to Erythrina and Lycorine Alkaloids.  Chemistry - A European Journal.  22:7262-7267.

Structure-Based Design of a Small Molecule CD4-Antagonist with Broad Spectrum Anti-HIV-1 Activity.  Journal of Medicinal Chemistry.  58:6909-6927.

ChemInform Abstract: Synthesis of Bicyclic Proline Derivatives by the Aza‐Cope—Mannich Reaction: Formal Synthesis of (.+‐.)‐Acetylaranotin..  ChemInform.  46:no-no.

Discovery of the 2-phenyl-4,5,6,7-Tetrahydro-1H-indole as a novel anti-hepatitis C virus targeting scaffold.  European Journal of Medicinal Chemistry.  96:250-258.

Synthesis of Bicyclic Proline Derivatives by the Aza-Cope-Mannich Reaction: Formal Synthesis of (±)-Acetylaranotin.  Chemistry - A European Journal.  21:4141-4147.

ChemInform Abstract: An Effective Activation of Palladium Phosphine Complexes in Aqueous Phase Reactions of Hetero‐Aromatic Boronic Acids with Aryl Halides..  ChemInform.  45:no-no.

ChemInform Abstract: Synthesis of Non‐Natural L‐Alanine Derivatives Using the Aza‐Cope—Mannich Reaction..  ChemInform.  45:no-no.

An Effective Activation of Palladium Phosphine Complexes in Aqueous Phase Reactions of Hetero-Aromatic Boronic Acids with Aryl Halides.  Chemistry of Heterocyclic Compounds.  50:19-25.

Synthesis of non-natural L-alanine derivatives using the aza-Cope-Mannich reaction.  Tetrahedron: Asymmetry: the international journal for rapid publication on all aspects of asymmetry in organic, inorganic, organometallic, physical and bioorganic chemistry.  25:468-472.

ChemInform Abstract: Synthesis of 4,5,6,7‐Tetrahydro‐1H‐indole Derivatives Through Successive Sonogashira Coupling/Pd‐Mediated 5‐endo‐dig Cyclization..  ChemInform.  44:no-no.

ChemInform Abstract: Highly Stereoselective and Scalable Synthesis of trans‐Fused Octahydrocyclohepta[b]pyrrol‐4(1H)‐ones via the Aza‐Cope—Mannich Rearrangement in Racemic and Enantiopure Forms..  ChemInform.  44:no-no.

Synthesis of 4,5,6,7-Tetrahydro-1H-indole Derivatives Through Successive Sonogashira Coupling/Pd-Mediated 5-endo-dig Cyclization.  European Journal of Organic Chemistry.  2013:649-652.

Highly Stereoselective and Scalable Synthesis of trans-Fused Octahydrocyclohepta[b]pyrrol-4(1H)-ones via the Aza-Cope-Mannich Rearrangement in Racemic and Enantiopure Forms.  Journal of Organic Chemistry.  77:10125-10134.

ChemInform Abstract: Palladium‐Catalyzed Carboamination in the Synthesis of Nitrogen‐Containing Heterocycles.  ChemInform.  43:no-no.

(1R, 3R,3aS,8aR)-4-Oxo-3-phenyl-1-[(1R)1-phenylethyl] decahydrocyclohepta[b]pyrrol-1-ium bromide.  Acta Crystallographica Section E: Crystallographic Communications.  68:O2227-+.

Palladium-catalyzed carboamination in the synthesis of nitrogen-containing heterocycles.  Chemistry of Heterocyclic Compounds.  48:73-81.

Synthesis of (3RS,3aSR,8aSR)-3-phenyloctahydrocyclohepta[b]pyrrol-4(1H)-one via the aza-Cope-Mannich rearrangement.  Tetrahedron.  67:9214-9218.

ChemInform Abstract: tert‐Butyl (2S)‐(p‐Tolylsulfonyloxy)propionate (II) — A Suitable Reagent for the Direct Alkylation of Indole Derivatives..  ChemInform.  40:no-no.

Tert-Butyl (25)-(4-methylphenylsulfonyloxy)propionate - Convenient reagent for the direct alkylation of indole derivatives.  Chemistry of Heterocyclic Compounds.  1391-1398.

tert-Butyl (2S)-(p-tolylsulfonyloxy)propionate - a suitable reagent for the direct alkylation of indole derivatives.  Chemistry of Heterocyclic Compounds.  44:1123-1128.

Correction to Synthesis, Antiviral Potency, in Vitro ADMET, and X-ray Structure of Potent CD4 Mimics as Entry Inhibitors That Target the Phe43 Cavity of HIV-1 gp120..  Journal of Medicinal Chemistry. 4734.

Synthesis of bicyclic proline derivatives by the aza-Cope-Mannich reaction: formal synthesis of (±)-acetylaranotin..  Chemistry - A European Journal. 4141-4147.

Olefin Metathesis by First-Row Transition Metals.  ChemPlusChem. 924-937.