Structure-based lead optimization to improve antiviral potency and ADMET properties of phenyl-1H-pyrrole-carboxamide entry inhibitors targeted to HIV-1 gp120 Article

Curreli, Francesca, Belov, Dmitry S, Do Kwon, Young et al. (2018). Structure-based lead optimization to improve antiviral potency and ADMET properties of phenyl-1H-pyrrole-carboxamide entry inhibitors targeted to HIV-1 gp120 . EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 154 367-391. 10.1016/j.ejmech.2018.04.062

Open Access International Collaboration

cited authors

  • Curreli, Francesca; Belov, Dmitry S; Do Kwon, Young; Ramesh, Ranjith; Furimsky, Anna M; O'Loughlin, Kathleen; Byrge, Patricia C; Iyer, Lalitha V; Mirsalis, Jon C; Kurkin, Alexander V; Altieri, Andrea; Debnath, Asim K

sustainable development goals

authors

publication date

  • June 25, 2018

webpage

published in

keywords

  • "CH2OH" switch hypothesis
  • ADMET
  • Broad spectrum
  • CCR5 CORECEPTOR
  • CD4 RECEPTOR
  • Chemistry, Medicinal
  • EARLY SUBTYPE
  • ENV CLONES
  • ENV-pseudovirus
  • FUSION INHIBITOR
  • HIV-1
  • HUMAN-IMMUNODEFICIENCY-VIRUS
  • Life Sciences & Biomedicine
  • PRODRUG BMS-663068
  • Pharmacology & Pharmacy
  • SMALL-MOLECULE INHIBITORS
  • SPECTRUM ANTI-HIV-1 ACTIVITY
  • STRUCTURE-BASED DESIGN
  • Science & Technology
  • Structure-activity relationship (SAR)
  • Virus entry antagonist

Digital Object Identifier (DOI)

publisher

  • ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER

start page

  • 367

end page

  • 391

volume

  • 154