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Abbott, Karen
Positions
Associate Professor
,
Translational Medicine
,
Herbert Wertheim College of Medicine
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Scholarly & Creative Works
Research
View All
Scholarly & Creative Works
selected scholarly works & creative activities
Article
2023
The clinical role of glycobiology on ovarian cancer progression
Full Text via DOI:
10.1016/bs.acr.2022.07.004
Web of Science:
001075073400002
2020
Analysis of GPI-anchored proteins involved in germline stem cell proliferation in the Caenorhabditis elegans germline stem cell niche
Full Text via DOI:
10.1093/jb/mvaa075
2020
Novel role for the Golgi membrane protein TMEM165 in control of migration and invasion for breast carcinoma
Full Text via DOI:
10.18632/oncotarget.27668
2019
Generation of a Fully Human scFv that binds Tumor-Specific Glycoforms
Full Text via DOI:
10.1038/s41598-019-41567-6
2018
CSIG-01. GLYCOPHOSPHATIDYLINOSITOL TRANSAMIDASE (GPIT) SUBUNIT GPAA1 IS OVEREXPRESSED IN GLIOBLASTOMA MULTIFORME (GBM) CELL LINES AND CONTRIBUTES TO TUMOR CELL MIGRATION
.
NEURO-ONCOLOGY
. 20:vi43-vi43.
Full Text via DOI:
10.1093/neuonc/noy148.167
2018
THE BIOLOGICAL IMPACT OF THE GOLGI MEMBRANE PROTEIN TMEM165 FOR BREAST CANCER
.
FASEB JOURNAL
. 32:667.3-667.3.
Full Text via DOI:
10.1096/fasebj.2018.32.1_supplement.667.3
2017
The glycosyltransferase GnT-III activates Notch signaling and drives stem cell expansion to promote the growth and invasion of ovarian cancer
.
JOURNAL OF BIOLOGICAL CHEMISTRY
. 292:16351-16359.
Full Text via DOI:
10.1074/jbc.M117.783936
2015
Glycomic analysis of membrane glycoproteins with bisecting glycosylation from ovarian cancer tissues reveals novel structures and functions
Full Text via DOI:
10.1021/pr501174p
2014
Elevated levels of glycosylphosphatidylinositol (GPI) anchored proteins in plasma from human cancers detected by C. septicum alpha toxin
Full Text via DOI:
10.3233/CBM-130377
2012
Proteomic identification of glycosylphosphatidylinositol anchor-dependent membrane proteins elevated in breast carcinoma
.
JOURNAL OF BIOLOGICAL CHEMISTRY
. 287:25230-25240.
Full Text via DOI:
10.1074/jbc.M112.339465
2011
Mannose receptor (MR) engagement by mesothelin GPI anchor polarizes tumor-associated macrophages and is blocked by anti-MR human recombinant antibody
Full Text via DOI:
10.1371/journal.pone.0028386
2010
Glycomic analysis of ovarian cancer: Past, present, and future
Full Text via DOI:
10.3233/CBM-2011-0218
2010
Identification of candidate biomarkers with cancer‐specific glycosylation in the tissue and serum of endometrioid ovarian cancer patients by glycoproteomic analysis
Full Text via DOI:
10.1002/prca.201090032
2010
Identification of candidate biomarkers with cancerspecific glycosylation in the tissue and serum of endometrioid ovarian cancer patients by glycoproteomic analysis
.
PROTEOMICS
. 10:470-481.
Full Text via DOI:
10.1002/pmic.200900537
2009
NMR structure of a complex formed by the carboxyl-terminal domain of human RAP74 and a phosphorylated peptide from the central domain of the FCP1 phosphatase
.
BIOCHEMISTRY
. 48:1964-1974.
Full Text via DOI:
10.1021/bi801549m
2008
Receptor tyrosine phosphatase β (RPTPβ) activity and signaling are attenuated by glycosylation and subsequent cell surface galectin-1 binding
.
JOURNAL OF BIOLOGICAL CHEMISTRY
. 283:33026-33035.
Full Text via DOI:
10.1074/jbc.M803646200
2008
Focused glycomic analysis of the N-linked glycan biosynthetic pathway in ovarian cancer
.
PROTEOMICS
. 8:3210-3220.
Full Text via DOI:
10.1002/pmic.200800157
2008
Targeted glycoproteomic identification of biomarkers for human breast carcinoma
Full Text via DOI:
10.1021/pr700792g
2006
Integrin-dependent neuroblastoma cell adhesion and migration on laminin is regulated by expression levels of two enzymes in the O-mannosyl-linked glycosylation pathway, PomGnT1 and GnT-Vb
.
EXPERIMENTAL CELL RESEARCH
. 312:2837-2850.
Full Text via DOI:
10.1016/j.yexcr.2006.05.022
2006
N-acetylglucosaminyltranferase VB expression enhances β1 integrin- dependent PC12 neurite outgrowth on laminin and collagen
.
JOURNAL OF NEUROCHEMISTRY
. 97:947-956.
Full Text via DOI:
10.1111/j.1471-4159.2006.03785.x
2005
Enhanced binding of RNAP II CTD phosphatase FCP1 to RAP74 following CK2 phosphorylation
.
BIOCHEMISTRY
. 44:2732-2745.
Full Text via DOI:
10.1021/bi047958h
2005
Interactions of the HIV-1 Tat and RAP74 proteins with the RNA polymerase II CTD phosphatase FCP1
.
BIOCHEMISTRY
. 44:2716-2731.
Full Text via DOI:
10.1021/bi047957p
2003
NMR structure of a complex containing the TFIIF subunit RAP74 and the RNA polymerase II carboxyl-terminal domain phosphatase FCP1
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
. 100:5688-5693.
Full Text via DOI:
10.1073/pnas.1031524100
2000
Transcriptional responses to growth factor and G protein-coupled receptors in PC12 cells: Comparison of α
1
-adrenergic receptor subtypes
.
JOURNAL OF NEUROCHEMISTRY
. 74:2392-2400.
Full Text via DOI:
10.1046/j.1471-4159.2000.0742392.x
2000
Differential regulation of vascular smooth muscle nuclear factor kappa-B by Gαq-coupled and cytokine receptors
Full Text via DOI:
10.1006/jmcc.1999.1085
2000
Evidence that Gα(q)-coupled receptor-induced interleukin-6 mRNA in vascular smooth muscle cells involves the nuclear factor of activated T cells
Full Text via DOI:
10.1124/mol.58.5.946
1998
The cyclosporin A-sensitive nuclear factor of activated T cells (NFAT) proteins are expressed in vascular smooth muscle cells. Differential localization of NFAT isoforms and induction of NFAT-mediated transcription by phospholipase C-coupled cell surface receptors
.
JOURNAL OF BIOLOGICAL CHEMISTRY
. 273:19664-19671.
Full Text via DOI:
10.1074/jbc.273.31.19664
1998
Activation and cellular localization of the cyclosporine A-sensitive transcription factor NF-AT in skeletal muscle cells
.
MOLECULAR BIOLOGY OF THE CELL
. 9:2905-2916.
Full Text via DOI:
10.1091/mbc.9.10.2905
1995
Reliability of differential PCR for the detection of EGFR and MDM2 gene amplification in DNA extracted from FFPE glioma tissue
.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
. 54:57-64.
Full Text via DOI:
10.1097/00005072-199501000-00007
1994
Non-isotopic in situ hybridization method for mitochondria in oncocytes
Full Text via DOI:
10.1177/42.2.8288868
1993
Mutations in the p53 gene in human astrocytomas: detection by single-strand conformation polymorphism analysis and direct DNA sequencing.
.
MODERN PATHOLOGY
. 6:442-445.
1993
Y chromosome loss in esophageal carcinoma: An in situ hybridization study
Full Text via DOI:
10.1002/gcc.2870080306
Book Chapter
2015
Functional impact of tumor-specific N-linked glycan changes in breast and ovarian cancers
. 281-303.
Full Text via DOI:
10.1016/bs.acr.2014.11.006
2010
Lectin-based glycoproteomic techniques for the enrichment and identification of potential biomarkers
. 461-476.
Full Text via DOI:
10.1016/S0076-6879(10)80020-5
2002
Retroviral vectors applied to gene regulation studies
. 539-551.
Full Text via DOI:
10.1016/S0076-6879(02)45045-8
Conference
2021
Glycomic changes of the notch 1 receptor in ovarian Cancer affect the cancer stem cell growth
.
GLYCOBIOLOGY
. 1766-1766.
Web of Science:
000754737200194
2021
Novel method for glycan-targeted scFvC9 chimeras to mediate receptor degradation in ovarian Cancer
.
GLYCOBIOLOGY
. 1765-1766.
Web of Science:
000754737200193
Research
principal investigator on
Glycomics Laboratory for the Development of Ovarian Cancer Biomarkers
awarded by
National Cancer Institute
2020 - 2023
Novel platform linking cancer-specific glycosylation with cell signaling outcomes
awarded by
National Cancer Institute
2020 - 2022
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