Y chromosome loss in esophageal carcinoma: An in situ hybridization study Article

Hunter, S, Gramlich, T, Abbott, K et al. (1993). Y chromosome loss in esophageal carcinoma: An in situ hybridization study . 8(3), 172-177. 10.1002/gcc.2870080306

cited authors

  • Hunter, S; Gramlich, T; Abbott, K; Varma, V

authors

abstract

  • Carcinoma of the esophagus shows a strong male predominance and other epidemiologic differences from cancers arising at other sites. In this study, the prevalence of Y chromosome loss in 29 carcinomas of the esophagus and 53 carcinomas arising elsewhere in the aerodigestive tract was assessed by in situ hybridization of formalin‐fixed paraffin‐embedded tissue sections. Absence of the Y chromosome was defined as (1) negative staining for Y in neoplastic cells with positive staining for Y in immediately adjacent nonneoplastic epithelial and stromal cells, (2) positive staining of neoplastic cells with control probes for chromosomes X and 17, and (3) similar results at different stringencies and levels of protein digestion. According to these criteria, absence of the Y chromosome was observed in 13 of 14 (93%) adenocarcinomas of the esophagus, 8 of 13 (62%) squamous cell carcinomas of the esophagus, and 5 of 53 (9%) carcinomas arising in other sites. For the neoplasms examined, Y chromosome deletion was strongly and selectively associated with carcinomas, particularly adenocarcinomas, of the esophagus (P < .0001). These findings suggest that Y chromosome loss may be pathogenetically significant in these neoplasms. © 1993 Wiley‐Liss, Inc. Copyright © 1993 Wiley‐Liss, Inc., A Wiley Company

publication date

  • January 1, 1993

Digital Object Identifier (DOI)

start page

  • 172

end page

  • 177

volume

  • 8

issue

  • 3