JOURNAL OF BIOLOGICAL CHEMISTRY

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JOURNAL OF BIOLOGICAL CHEMISTRY Journal

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Minor electrostatic changes robustly increase VP40 membrane binding, assembly, and budding of Ebola virus matrix protein derived virus-like particles.. 107213. 2024
Plasmodium parasitophorous vacuole membrane protein Pfs16 promotes malaria transmission by silencing mosquito immunity. 299. 2023
Lipid-specific oligomerization of the Marburg virus matrix protein VP40 is regulated by two distinct interfaces for virion assembly. 296. 2021
R-loops promote trinucleotide repeat deletion through DNA base excision repair enzymatic activities. 295:13902-13913. 2020
Phospholipase D2 restores endothelial barrier function by promoting PTPN14-mediated VE-cadherin dephosphorylation. 295:7669-7685. 2020
Glycoengineering of chimeric antigen receptor (CAR) T-cells to enforce E-selectin binding. 294:18465-18474. 2019
Protamines from liverwort are produced by post-translational cleavage and C-terminal di-aminopropanelation of several male germ-specific H1 histones. 294:16364-16373. 2019
N-Glycosylation regulates ligand-dependent activation and signaling of vascular endothelial growth factor receptor 2 (VEGFR2). 294:13117-13130. 2019
Peroxynitrite supports a metabolic reprogramming in merlin-deficient Schwann cells and promotes cell survival. 294:11354-11368. 2019
Crystal structure of a novel domain of the motor subunit of the Type i restriction enzyme EcoR124 involved in complex assembly and DNA binding. 293:15043-15054. 2018
Communication between N terminus and loop2 tunes Orai activation. 293:1271-1285. 2018
The glycosyltransferase GnT-III activates Notch signaling and drives stem cell expansion to promote the growth and invasion of ovarian cancer. 292:16351-16359. 2017
Human retinal pigment epithelial cells prefer proline as a nutrient and transport metabolic intermediates to the retinal side. 292:12895-12905. 2017
Phototransduction influences metabolic flux and nucleotide metabolism in mouse retina. 291:4698-4710. 2016
Structural insights into the assembly of the adeno-associated virus type 2 Rep68 protein on the integration site AAVS1. 290:27487-27499. 2015
Role of c-Met/Phosphatidylinositol 3-Kinase (PI3k)/Akt Signaling in Hepatocyte Growth Factor (HGF)- mediated Lamellipodia Formation, Reactive Oxygen Species (ROS) Generation, and Motility of Lung Endothelial Cells. 289:13476-13491. 2014
Activity of ADAM17 (a disintegrin and metalloprotease 17) is regulated by its noncatalytic domains and secondary structure of its substrates. 288:22871-22879. 2013
Enhancement of Human DNA Polymerase η Activity and Fidelity Is Dependent Upon a Bipartite Interaction with the Werner Syndrome Protein. 287:42312-42323. 2012
Discovery of novel inhibitors of a disintegrin and metalloprotease 17 (ADAM17) using glycosylated and non-glycosylated substrates. 287:36473-36487. 2012
Proteomic identification of glycosylphosphatidylinositol anchor-dependent membrane proteins elevated in breast carcinoma. 287:25230-25240. 2012
Corneal antifibrotic switch identified in genetic and pharmacological deficiency of vimentin. 287:989-1006. 2012
Sugar binding residue affects apparent Na⁺ affinity and transport stoichiometry in mouse sodium/glucose cotransporter type 3B. 286:7975-7982. 2011
Natural and engineered photoactivated nucleotidyl cyclases for optogenetic applications. 285:41501-41508. 2010
beta-Actin Association with Endothelial Nitric-oxide Synthase Modulates Nitric Oxide and Superoxide Generation from the Enzyme. 285:4319-4327. 2010
A synthetic combinatorial strategy for developing α-conotoxin analogs as potent α7 nicotinic acetylcholine receptor antagonists. 285:1809-1821. 2010
Coordination between polymerase β and FEN1 can modulate CAG repeat expansion. 284:28352-28366. 2009
Structural and Functional Characterizations of SsgB, a Conserved Activator of Developmental Cell Division in Morphologically Complex Actinomycetes. 284:25268-25279. 2009
Regulation of platelet-derived growth factor receptor function by integrin-associated cell surface transglutaminase. 284:16693-16703. 2009
Role of Bound Zn(II) in the CadC Cd(II)/Pb(II)/Zn(II)-responsive Repressor. 284:14958-14965. 2009
Protein kinase A-mediated gating of neuregulin-dependent ErbB2-ErbB3 activation underlies the synergistic action of cAMP on schwann cell proliferation. 283:34087-34100. 2008
Receptor tyrosine phosphatase β (RPTPβ) activity and signaling are attenuated by glycosylation and subsequent cell surface galectin-1 binding. 283:33026-33035. 2008
Therapeutic gene silencing delivered by a chemically modified small interfering RNA against mutant SOD1 slows amyotrophic lateral sclerosis progression. 283:15845-15852. 2008
The hominoid-specific oncogene TBC1d3 activates ras and modulates epidermal growth factor receptor signaling and trafficking. 283:13233-13242. 2008
An arsenate-activated glutaredoxin from the arsenic hyperaccumulator fern Pteris vittata L. regulates intracellular arsenite. 283:6095-6101. 2008
Coordination of steps in single-nucleotide base excision repair mediated by apurinic/apyrimidinic endonuclease 1 and DNA polymerase β. 282:13532-13541. 2007
Biochemical, molecular, and functional characterization of PISCF-allatostatin, a regulator of juvenile hormone biosynthesis in the mosquito Aedes aegypti. 281:34048-34055. 2006
Cys-113 and Cys-422 form a high affinity metalloid binding site in the ArsA ATPase. 281:9925-9934. 2006
Hypothyroid phenotype is contributed by mitochondrial complex I inactivation due to translocated neuronal nitric-oxide synthase. 281:4779-4786. 2006
Identification of a novel recognition sequence for fibronectin within the NH2-terminal β-sandwich domain of tissue transglutaminase. 280:23675-23683. 2005
Inhibition of protein-tyrosine phosphatases by mild oxidative stresses is dependent on S-nitrosylation. 280:14453-14461. 2005
DNA polymerase beta and flap endonuclease 1 enzymatic specificities sustain DNA synthesis for long patch base excision repair.. 280:3665-3674. 2005
Cellular, biochemical, and genetic analysis of mechanism of small molecule IAP inhibitors. 279:48168-48176. 2004
Coupling DNA supercoiling to transcription in defined protein systems. 279:47564-47571. 2004
Protein kinase C theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101). 279:45304-45307. 2004
Site-directed mutagenesis of residues involved in G strand DNA binding by Escherichia coli DNA topoisomerase I. 279:39207-39213. 2004
Leishmania major LmACR2 is a pentavalent antimony reductase that confers sensitivity to the drug Pentostam. 279:37445-37451. 2004
Inhibition of furin by polyarginine-containing peptides: Nanomolar inhibition by nona-D-arginine. 279:36788-36794. 2004
Drug uptake and modulation of drug resistance in Leishmania by an aquaglyceroporin. 279:31010-31017. 2004
As(III) and Sb(III) uptake by G1pF and efflux by ArsB in Escherichia coli. 279:18334-18341. 2004
Arsenic trioxide uptake by hexose permeases in Saccharomyces cerevisiae. 279:17312-17318. 2004
Structure-function analysis of the reactive site in the first Kunitz-type domain of human tissue factor pathway inhibitor-2. 279:17500-17507. 2004
Flexibility at Gly-194 is required for DNA cleavage and relaxation activity of Escherichia coli DNA topoisomerase I. 279:8648-8654. 2004
Reversible Inhibitors of λ Integrase-mediated Recombination Efficiently Trap Holliday Junction Intermediates and Form the Basis of a Novel Assay for Junction Resolution. 279:3472-3483. 2004
The Src homology 2 domain of Rin1 mediates its binding to the epidermal growth factor receptor and regulates receptor endocytosis. 278:32027-32036. 2003
Direct interaction between Escherichia coli RNA polymerase and the zinc ribbon domains of DNA topoisomerase I. 278:30705-30710. 2003
Repressors of androgen and progesterone receptor action. 278:31136-31148. 2003
Directed evolution of a yeast arsenate reductase into a protein-tyrosine phosphatase. 278:24476-24480. 2003
Analysis of human flap endonuclease 1 mutants reveals a mechanism to prevent triplet repeat expansion. 278:13728-13739. 2003
Two-dimensional NMR study of the heme active site structure of chloroperoxidase. 278:7765-7774. 2003
Biochemical characterization of CopA, the Escherichia coli Cu(I)-translocating P-type ATPase. 277:46987-46992. 2002
The soft metal ion binding sites in the Staphylococcus aureus pI258 CadC Cd(II)/Pb(II)/Zn(II)-responsive repressor are formed between subunits of the homdimer. 277:40930-40936. 2002
1,25-Dihydroxyvitamin D down-regulates cell membrane growth- and nuclear growth-promoting signals by the epidermal growth factor receptor. 277:38965-38971. 2002
Evidence for cooperativity between the four binding sites of dimeric ArsD, an As(III)-responsive transcriptional regulator. 277:25992-26002. 2002
Unisite and multisite catalysis in the ArsA ATPase. 277:23815-23820. 2002
Activation of constitutive nitric-oxide sythase activity is an early signaling event induced by ionizing radiation. 277:15400-15406. 2002
Cleavage specificity of Saccharomyces cerevisiae flap endonuclease 1 suggests a double-flap structure as the cellular substrate. 277:14379-14389. 2002
Bicarbonate enhances peroxidase activity of Cu,Zn-superoxide dismutase: Role of carbonate anion radical and scavenging of carbonate anion radical by metalloporphyrin antioxidant enzyme mimetics. 277:1013-1020. 2002
Residue 457 Controls Sugar Binding and Transport in the Na ⁺/Glucose Cotransporter. 276:49188-49194. 2001
Differential L-selectin binding activities of human hematopoietic cell L-selectin ligands, HCELL and PSGL-1. 276:47623-47631. 2001
Phosphatidylinositol-4-phosphate 5-Kinase-1β Is Essential for Epidermal Growth Factor Receptor-mediated Endocytosis. 276:47212-47216. 2001
The phosphatase C(X)(5)R motif is required for catalytic activity of the Saccharomyces cerevisiae Acr2p arsenate reductase. 276:34738-34742. 2001
Conformational changes in four regions of the Escherichia coli ArsA ATPase link ATP hydrolysis to ion translocation. 276:30414-30422. 2001
The Leishmania ATP-binding cassette protein PGPA is an intracellular metal-thiol transporter ATPase. 276:26301-26307. 2001
Role of cysteinyl residues in sensing Pb(II), Cd(II), and Zn(II) by the plasmid pI258 CadC repressor. 276:14955-14960. 2001
A kinetic model for the action of a resistance efflux pump. 276:6378-6391. 2001
Polyarginines are potent furin inhibitors. 275:36741-36749. 2000
Cell volume-dependent phosphorylation of proteins of the cortical cytoskeleton and cell-cell contact sites. The role of Fyn and FER kinases. 275:32289-32298. 2000
A novel membrane-anchored Rab5 interacting protein required for homotypic endosome fusion. 275:24661-24669. 2000
Purification and characterization of Acr2p, the Saccharomyces cerevisiae arsenate reductase. 275:21149-21157. 2000
Inhibition of flap endonuclease 1 by flap secondary structure and relevance to repeat sequence expansion. 275:16420-16427. 2000
The acidic triad conserved in type IA DNA topoisomerases is required for binding of Mg(II) and subsequent conformational change. 275:5318-5322. 2000
The ATP hydrolytic activity of purified ZntA, a Pb(II)/Cd(II)/Zn(II)-translocating ATPase from Escherichia coli. 275:3873-3878. 2000
Reactivity of glutaredoxins 1, 2, and 3 from Escherichia coli shows that glutaredoxin 2 is the primary hydrogen donor to ArsC-catalyzed arsenate reduction. 274:36039-36042. 1999
The ATPase mechanism of ArsA, the catalytic subunit of the arsenite pump. 274:16153-16161. 1999
Asp(45) is a Mg2+ ligand in the ArsA ATPase. 274:13854-13858. 1999
Binding of xanthine oxidase to vascular endothelium - Kinetic characterization and oxidative impairment of nitric oxide-dependent signaling. 274:4985-4994. 1999
Pb(II)-translocating P-type ATPases. 273:32614-32617. 1998
Identification of inhibitors of prohormone convertases 1 and 2 using a peptide combinatorial library. 273:26589-26595. 1998
Evidence for a symmetrical requirement for Rab5-GTP in in vitro endosome-endosome fusion. 273:25850-25855. 1998
Growth factor-dependent phosphorylation of the actin-binding protein cortactin is mediated by the cytoplasmic tyrosine kinase FER. 273:23542-23548. 1998
Protein kinase B/akt and Rab5 mediate Ras activation of endocytosis. 273:19367-19370. 1998
The cyclosporin A-sensitive nuclear factor of activated T cells (NFAT) proteins are expressed in vascular smooth muscle cells. Differential localization of NFAT isoforms and induction of NFAT-mediated transcription by phospholipase C-coupled cell surface receptors. 273:19664-19671. 1998
Selective ligands for the μ, δ, and κ opioid receptors identified from a single mixture based tetrapeptide positional scanning combinatorial library. 273:18848-18856. 1998
A novel mechanism-based inhibitor (6′-bromo-5′,6′-didehydro-6′-deoxy-6′-fluorohomoadenosine) that covalently modifies human placental S-adenosylhomocysteine hydrolase. 273:18191-18197. 1998
Site-directed mutagenesis of conserved aspartates, glutamates and arginines in the active site region of Escherichia coli DNA topoisomerase I. 273:8783-8789. 1998
Steric limitations in the interaction of the ATP binding domains of the ArsA ATPase. 273:6796-6800. 1998
Ligand interactions of the ArsC arsenate reductase. 272:21084-21089. 1997
Tryptophan fluorescence reports nucleotide-induced conformational changes in a domain of the ArsA ATPase. 272:19731-19737. 1997
Effect of Mg(II) binding on the structure and activity of Escherichia coli DNA topoisomerase I. 272:16206-16210. 1997
Dimerization is essential for DNA binding and repression by the ArsR metalloregulatory protein of Escherichia coli. 272:15734-15738. 1997
Metalloregulatory properties of the ArsD repressor. 272:14257-14262. 1997
Uncoupling of membrane ruffling and pinocytosis during Ras signal transduction. 272:10337-10340. 1997
Alternate energy coupling of ArsB, the membrane subunit of the Ars anion-translocating ATPase. 272:326-331. 1997
His-8 lowers the pK(a) of the essential Cys-12 residue of the ArsC arsenate reductase of plasmid R773. 271:33256-33260. 1996
Interaction of ATP binding sites in the ArsA ATPase, the catalytic subunit of the Ars pump. 271:25247-25252. 1996
Spatial proximity of Cys(113), Cys(172), and Cys(422) in the metalloactivation domain of the ArsA ATPase. 271:24465-24470. 1996
Phagocytosed live Listeria monocytogenes influences rab5-regulated in vitro phagosome-endosome fusion. 271:13834-13843. 1996
The role of arsenic thiol interactions in metalloregulation of the ars operon. 271:9291-9297. 1996
Functionalized protein-like structures from conformationally defined synthetic combinatorial libraries. 271:4120-4126. 1996
Identification of inhibitors of melittin using nonsupport-bound combinatorial libraries. 271:4093-4099. 1996
The chromosomal arsR gene of Escherichia coli encodes a trans-acting metalloregulatory protein. 271:2427-2432. 1996
ROLE OF CYSTEINYL RESIDUES IN METALLOACTIVATION OF THE OXYANION-TRANSLOCATING ARSA ATPASE. 270:11245-11250. 1995
The role of amphipathicity in the folding, self-association and biological activity of multiple subunit small proteins. 270:1048-1056. 1995
ATP-DEPENDENT ARSENITE TRANSPORT IN EVERTED MEMBRANE-VESICLES OF ESCHERICHIA-COLI. 269:25442-25446. 1994
IDENTIFICATION OF A PUTATIVE METAL-BINDING SITE IN A NEW FAMILY OF METALLOREGULATORY PROTEINS. 269:19826-19829. 1994
Synthetic compound peptide simulating antigenicity of conformation-dependent autoepitope. 269:18529-18534. 1994
STRUCTURAL FEATURES OF THE GTP-BINDING DEFECTIVE RAB5 MUTANTS REQUIRED FOR THEIR INHIBITORY ACTIVITY ON ENDOCYTOSIS. 269:14631-14635. 1994
CONTRIBUTION OF THE LEISHMANIA P-GLYCOPROTEIN-RELATED GENE LTPGPA TO OXYANION RESISTANCE. 269:11980-11986. 1994
IN-VITRO ASSEMBLY OF AN ANION-STIMULATED ATPASE FROM PEPTIDE-FRAGMENTS. 269:9698-9704. 1994
Mutations of vaccinia virus DNA topoisomerase I that stabilize the cleavage complex. 269:573-578. 1994
METALLOREGULATED EXPRESSION OF THE ARS OPERON. 268:52-58. 1993
CONSTRUCTION OF A CHIMERIC ARSA-ARSB PROTEIN FOR OVEREXPRESSION OF THE OXYANION-TRANSLOCATING ATPASE. 267:25768-25775. 1992
MUTAGENESIS OF THE C-TERMINAL NUCLEOTIDE-BINDING SITE OF AN ANION-TRANSLOCATING ATPASE. 267:19272-19277. 1992
MEMBRANE TOPOLOGY OF THE ARSB PROTEIN, THE MEMBRANE SUBUNIT OF AN ANION-TRANSLOCATING ATPASE. 267:12570-12576. 1992
Identification of a sequence of human activated protein C (residues 390-404) essential for its anticoagulant activity. 266:24514-24519. 1991
ZINC(II) COORDINATION IN ESCHERICHIA-COLI DNA TOPOISOMERASE-I IS REQUIRED FOR CLEAVABLE COMPLEX-FORMATION WITH DNA. 266:14317-14320. 1991
SUBSTRATE-INDUCED DIMERIZATION OF THE ARSA PROTEIN, THE CATALYTIC COMPONENT OF AN ANION-TRANSLOCATING ATPASE. 266:2327-2332. 1991
MUTAGENESIS OF A NUCLEOTIDE-BINDING SITE OF AN ANION-TRANSLOCATING ATPASE. 265:7832-7836. 1990
Identification of a site in the α chain of platelet glycoprotein Ib that participates in von Willebrand factor binding. 265:274-280. 1990
MOLECULAR CHARACTERIZATION OF AN ANION PUMP - THE ARSB PROTEIN IS THE MEMBRANE ANCHOR FOR THE ARSA PROTEIN. 265:190-194. 1990
CHARACTERIZATION OF THE CATALYTIC SUBUNIT OF AN ANION PUMP. 264:17349-17354. 1989
Structure of the von Willebrand factor domain interacting with glycoprotein Ib. 263:17901-17904. 1988
An immunogenic region within residues Val¹⁶⁷⁰-Glu¹⁶⁸⁴ of the factor VIII light chain induces antibodies which inhibit binding of factor VIII to von Willebrand factor. 263:5230-5234. 1988
Generation and characterization of peptide-specific antibodies that inhibit Von Willebrand factor binding to glycoprotein IIb-IIIa without interacting with other adhesive molecules. Selectivity is conferred by Pro¹⁷⁴³ and other amino acid residues adjacent to the sequence Arg¹⁷⁴⁴-Gly¹7. 263:7500-7505. 1988
Localization of the binding site for a factor VIII activity neutralizing antibody to amino acid residues Asp¹⁶⁶³-Ser¹⁶⁶⁹. 263:10198-10203. 1988
Temporary decrease in renal quinone reductase activity induced by chronic administration of estradiol to male Syrian hamsters. Increased superoxide formation by redox cycling of estrogen. 263:3646-3651. 1988
MAINTENANCE OF INTRACELLULAR CALCIUM IN ESCHERICHIA-COLI. 262:12570-12574. 1987
RECONSTITUTION OF ATP-DEPENDENT CALCIUM-TRANSPORT FROM STREPTOCOCCI. 261:5596-5600. 1986
NUCLEOTIDE-SEQUENCE OF THE STRUCTURAL GENES FOR AN ANION PUMP - THE PLASMID-ENCODED ARSENICAL RESISTANCE OPERON. 261:5030-5038. 1986
UNCOUPLING OF THE DNA BREAKING AND REJOINING STEPS OF ESCHERICHIA-COLI TYPE-I DNA TOPOISOMERASE - DEMONSTRATION OF AN ACTIVE COVALENT PROTEIN-DNA COMPLEX. 261:931-935. 1986
CATION PROTON ANTIPORT SYSTEMS IN ESCHERICHIA-COLI - SOLUBILIZATION AND RECONSTITUTION OF DELTA-PH-DRIVEN SODIUM PROTON AND CALCIUM PROTON ANTIPORTERS. 261:678-683. 1986
CALCIUM EFFLUX FROM ESCHERICHIA-COLI - EVIDENCE FOR 2 SYSTEMS. 259:6142-6146. 1984
PHYLOGENETIC CONSERVATION OF A CLASS-III MAJOR HISTOCOMPATIBILITY COMPLEX ANTIGEN, FACTOR-B - ISOLATION AND NUCLEOTIDE SEQUENCING OF MOUSE FACTOR-B CDNA CLONES. 258:4693-4697. 1983
CATION-PROTON ANTIPORT SYSTEMS IN ESCHERICHIA-COLI - PROPERTIES OF THE POTASSIUM-PROTON ANTIPORTER. 255:39-44. 1980
COVALENT BONDS BETWEEN PROTEIN AND DNA - FORMATION OF PHOSPHOTYROSINE LINKAGE BETWEEN CERTAIN DNA TOPOISOMERASES AND DNA. 255:5560-5565. 1980
CATION-PROTON ANTIPORT SYSTEMS IN ESCHERICHIA-COLI - PROPERTIES OF THE CALCIUM-PROTON ANTIPORTER. 254:1957-1963. 1979
Bacterial luciferase subunits are synthesized in equal quantities. 252:803-805. 1977
CALCIUM-TRANSPORT DRIVEN BY A PROTON GRADIENT IN INVERTED MEMBRANE-VESICLES OF ESCHERICHIA-COLI. 251:962-967. 1976
CHARACTERIZATION OF AN ACTIVE-TRANSPORT SYSTEM FOR CALCIUM IN INVERTED MEMBRANE-VESICLES OF ESCHERICHIA-COLI. 250:7687-7692. 1975
ENERGY TRANSDUCTION IN ESCHERICHIA-COLI - ROLE OF MG2+ATPASE. 250:8409-8415. 1975
BASIC AMINO ACID TRANSPORT IN ESCHERICHIA-COLI. 246:3653-+. 1971
PURIFICATION AND CHARACTERIZATION OF A HISTIDINE-BINDING PROTEIN FROM SALMONELLA-TYPHIMURIUM LT-2 AND ITS RELATIONSHIP TO HISTIDINE PERMEASE SYSTEM. 246:5351-+. 1971
RAB5, AN EARLY ACTING ENDOSOMAL GTPASE, SUPPORTS IN-VITRO ENDOSOME FUSION WITHOUT GTP HYDROLYSIS 1994
AN ENGINEERED MUTANT OF VACCINIA VIRUS-DNA TOPOISOMERASE-I IS SENSITIVE TO THE ANTICANCER DRUG CAMPTOTHECIN 1992
ESCHERICHIA-COLI DNA TOPOISOMERASE-I IS A ZINC METALLOPROTEIN WITH 3 REPETITIVE ZINC-BINDING DOMAINS 1988
MOLECULAR CHARACTERIZATION OF AN ANION PUMP - THE ARSA GENE-PRODUCT IS AN ARSENITE(ANTIMONATE)-STIMULATED ATPASE 1988
CATION-PROTON ANTIPORT SYSTEMS IN ESCHERICHIA-COLI - ABSENCE OF POTASSIUM-PROTON ANTIPORTER ACTIVITY IN A PH-SENSITIVE MUTANT 1980
Protamines, in the footsteps of linker histone evolution 2006
Escherichia coli soft metal ion-translocating ATPases 2000
PSI relieves the pressure of membrane fusion 2020
Erratum: Structure-function analysis of the reactive site in the first Kunitz-type domain of human tissue factor pathway inhibitor-2 (Journal of Biological Chemistry (2004) 279 (17500-17507)) 2004
Structure-function analysis of the reactive site in the first Kunitz-type domain of human tissue factor pathway inhibitor-2 (vol 279, pg 17500, 2004) 2004

category

BIOCHEMISTRY & MOLECULAR BIOLOGY Category

International Standard Serial Number (ISSN)

0021-9258

Electronic International Standard Serial Number (EISSN)

1083-351X

journal abbreviation

J BIOL CHEM