Shetty's research interests and expertise are in basic and applied aspects of microbial processes related to environment, agroecosystem and health. He is interested in synergistic integration of both basic and applied science aspects in our research projects. His areas of research interest and expertise include - Management of soil-borne fungal diseases using biofumigants; Biocontrol of phytopathogens; Biological control of exotic invasive plant species using indigenous phytopathogens; Microbial biodegradation of marine and fresh water algal biotoxins; Endophytic microorganisms; Detection of Indoor toxic mold growth using signature volatile organic compounds; Allelopathic chemical interactions in suppression of invasive plant species; Microbial and plant based biofuel and bio-product production; Plant-microbial symbiosis; plant microbiome and soil microbial diversity; Biocontrol of foodborne pathogens in soil and on plant; Bioremediation (Heavy metals using plants, Pentachlorophenol and Polycyclic aromatic hydrocarbons using bacteria and white-rot fungi); Restoration ecology and ecological risk assessment following bioremediation. He enjoys teaching a wide variety of courses within the fields of Agriculture and Environmental sciences. Courses he teaches - Sustainable Agriculture, Integrated pest management, Soil Microbiology, Energy Resources, Introduction to Environmental Science and sustainability, Food Security and food safety, Sustainable Bioenergy, Agroecology, Special topics "Agriculture Colloquium".