Liberles, Jessica Siltberg

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Liberles, Jessica Siltberg Graduate Faculty

Positions

Associate Professor, Biological Sciences , College of Arts, Sciences & Education

jliberle@fiu.edu

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overview

Dr. Jessica Siltberg Liberles is an Assistant Professor of Biological Sciences, specializing in Bioinformatics.

selected scholarly works & creative activities

Article
- 2022
  
  Comparative Analysis of Structural Features in SLiMs from Eukaryotes, Bacteria, and Viruses with Importance for Host-Pathogen Interactions. Pathogens. 11.
  Full Text via DOI: 10.3390/pathogens11050583 Web of Science: 000803497200001
- 2020
  
  A Phylogenetic Rate Parameter Indicates Different Sequence Divergence Patterns in Orthologs and Paralogs. Journal of Molecular Evolution. 88:720-730.
  Full Text via DOI: 10.1007/s00239-020-09969-7 Web of Science: 000584914900001
- 2020
  
  Exploring Evolutionary Constraints in the Proteomes of Zika, Dengue, and Other Flaviviruses to Find Fitness-Critical Sites. Journal of Molecular Evolution. 88:399-414.
  Full Text via DOI: 10.1007/s00239-020-09941-5 Web of Science: 000524410600001
- 2020
  
  Potential RNA-dependent RNA polymerase inhibitors as prospective therapeutics against SARS-CoV-2. Journal of Medical Microbiology. 69:864-873.
  Full Text via DOI: 10.1099/jmm.0.001203 Web of Science: 000546951100013
- 2018
  
  Large-Scale Analyses of Site-Specific Evolutionary Rates across Eukaryote Proteomes Reveal Confounding Interactions between Intrinsic Disorder, Secondary Structure, and Functional Domains. Genes. 9.
  Full Text via DOI: 10.3390/genes9110553 Web of Science: 000451636700038
- 2018
  
  Interaction of Peptide Aptamers with Prion Protein Central Domain Promotes α-Cleavage of PrP^C. Molecular Neurobiology. 55:7758-7774.
  Full Text via DOI: 10.1007/s12035-018-0944-9 Web of Science: 000444207800011
- 2016
  
  Avoiding Regions Symptomatic of Conformational and Functional Flexibility to Identify Antiviral Targets in Current and Future Coronaviruses. Genome Biology and Evolution. 8:3471-3484.
  Full Text via DOI: 10.1093/gbe/evw246 Web of Science: 000393815300017
- 2016
  
  Paralog-Specific Patterns of Structural Disorder and Phosphorylation in the Vertebrate SH3-SH2-Tyrosine Kinase Protein Family. Genome Biology and Evolution. 8:2806-2825.
  Full Text via DOI: 10.1093/gbe/evw194 Web of Science: 000384307900013
- 2016
  
  The Nuanced Interplay of Intrinsic Disorder and Other Structural Properties Driving Protein Evolution. Molecular Biology and Evolution (MBE). 33:2248-2256.
  Full Text via DOI: 10.1093/molbev/msw092 Web of Science: 000381702500007
- 2016
  
  Functional Diversification after Gene Duplication: Paralog Specific Regions of Structural Disorder and Phosphorylation in p53, p63, and p73. PLoS ONE. 11.
  Full Text via DOI: 10.1371/journal.pone.0151961 Web of Science: 000372697400060
- 2014
  
  Engineering adenylate cyclases regulated by near-infrared window light. Proceedings of the National Academy of Sciences of the United States of America. 111:10167-10172.
  Full Text via DOI: 10.1073/pnas.1324301111 Web of Science: 000338985700041
- 2014
  
  Did the prion protein become vulnerable to misfolding after an evolutionary divide and conquer event?. Journal of Biomolecular Structure and Dynamics. 32:1074-1084.
  Full Text via DOI: 10.1080/07391102.2013.809022
- 2013
  
  Metazoan innovation: From aromatic amino acids to extracellular signaling. Amino Acids. 45:359-367.
  Full Text via DOI: 10.1007/s00726-013-1509-x
- 2013
  
  Rapid evolutionary dynamics of structural disorder as a potential driving force for biological divergence in flaviviruses. Genome Biology and Evolution. 5:504-513.
  Full Text via DOI: 10.1093/gbe/evt026
- 2011
  
  Evolution of structurally disordered proteins promotes neostructuralization. Molecular Biology and Evolution (MBE). 28:59-62.
  Full Text via DOI: 10.1093/molbev/msq291
- 2010
  
  Natural and engineered photoactivated nucleotidyl cyclases for optogenetic applications. Journal of Biological Chemistry. 285:41501-41508.
  Full Text via DOI: 10.1074/jbc.M110.177600
- 2010
  
  Piriform spider silk sequences reveal unique repetitive elements. Biomacromolecules. 11:3000-3006.
  Full Text via DOI: 10.1021/bm1007585
- 2010
  
  Superstoichiometric binding of L-Phe to phenylalanine hydroxylase from Caenorhabditis elegans: Evolutionary implications. Amino Acids. 39:1463-1475.
  Full Text via DOI: 10.1007/s00726-010-0611-6
- 2009
  
  Formyl peptide receptors are candidate chemosensory receptors in the vomeronasal organ. Proceedings of the National Academy of Sciences of the United States of America. 106:9842-9847.
  Full Text via DOI: 10.1073/pnas.0904464106
- 2009
  
  Searching distant homologs of the regulatory ACT domain in phenylalanine hydroxylase. Amino Acids. 36:235-249.
  Full Text via DOI: 10.1007/s00726-008-0057-2
- 2008
  
  The phylogeny of the aromatic amino acid hydroxylases revisited by characterizing phenylalanine hydroxylase from Dictyostelium discoideum. Gene. 427:86-92.
  Full Text via DOI: 10.1016/j.gene.2008.09.005
Conference
- 2017
  
  Evolution of Multi-Domain Conformational Ensembles from the Tyrosine Kinase Family. Protein Science. 104-105.
  Web of Science: 000418795900203
- 2015
  
  Peptide aptamers binding to PrPC inhibit prion protein misfolding. Prion. S35-S35.
  Web of Science: 000354444900063
- 2014
  
  Peptide aptamers interfering with PrPC-PrPSc interaction inhibit prion protein misfolding. Prion. 29-29.
  Web of Science: 000340614900066
- 2009
  
  Evolution of regulation, structure and function in phenylalanine hydroxylase. Pteridines. 42-50.
Review
- 2021
  
  Dynamic, but Not Necessarily Disordered, Human-Virus Interactions Mediated through SLiMs in Viral Proteins. Viruses.
  Full Text via DOI: 10.3390/v13122369 Web of Science: 000737305700001
- 2017
  
  Evolution of intrinsic disorder in eukaryotic proteins. Cellular and Molecular Life Sciences. 3163-3174.
  Full Text via DOI: 10.1007/s00018-017-2559-0 Web of Science: 000406500700006
- 2011
  
  The evolution of protein structures and structural ensembles under functional constraint. Genes. 748-762.
  Full Text via DOI: 10.3390/genes2040748

principal investigator on

Engaging and Mentoring through Biomedical Research And Career Exploration (EMBRACE) awarded by Allergy and Infectious Diseases 2023 - 2028
Investigating Career & Research Experience Access Through Evidence (iCREATE) awarded by National Institutes of Health 2022 - 2027
Authentic Bioinformatics in the Classroom (ABC) Project awarded by General Medical Sciences 2022 - 2027

co-principal investigator on

Grant
- RAPID: Bioinformatic Search for Epitope-based Molecular Mimicry in the SARS-CoV-2 Virus Using Chameleon awarded by National Science Foundation 2020 - 2022

investigator on

FIU-Diversity Center for Genomic Research (FIU-DCGR) awarded by National Human Genome Research Institute 2024 - 2026

full name

Jessica Liberles

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Co-investigator Network