Synthesis and evaluation of frentizole-based indolyl thiourea analogues as MAO/ABAD inhibitors for Alzheimer's disease treatment Article

Hroch, Lukas, Guest, Patrick, Benek, Ondrej et al. (2017). Synthesis and evaluation of frentizole-based indolyl thiourea analogues as MAO/ABAD inhibitors for Alzheimer's disease treatment . BIOORGANIC & MEDICINAL CHEMISTRY, 25(3), 1143-1152. 10.1016/j.bmc.2016.12.029

Open Access International Collaboration

cited authors

  • Hroch, Lukas; Guest, Patrick; Benek, Ondrej; Soukup, Ondrej; Janockova, Jana; Dolezal, Rafael; Kuca, Kamil; Aitken, Laura; Smith, Terry K; Gunn-Moore, Frank; Zala, Dominykas; Ramsay, Rona R; Musilek, Kamil

sustainable development goals

authors

publication date

  • February 1, 2017

published in

keywords

  • 17 beta-Hydroxysteroid dehydrogenase type 10 (17 beta-HSD10)
  • A-BETA ACCUMULATION
  • ABAD
  • AMYLOID CASCADE HYPOTHESIS
  • Alzheimer's disease (AD)
  • Amyloid-beta peptide (A beta)
  • BIOLOGICAL EVALUATION
  • Biochemistry & Molecular Biology
  • Chemistry
  • Chemistry, Medicinal
  • Chemistry, Organic
  • DIRECTED LIGANDS
  • Horseradish peroxidase (HRP)
  • IN-VITRO EVALUATION
  • Life Sciences & Biomedicine
  • MAO-B
  • MITOCHONDRIAL DYSFUNCTION
  • MONOAMINE-OXIDASE-B
  • Mitochondrial amyloid-binding alcohol dehydrogenase (ABAD)
  • Monoamine oxidase (MAO)
  • NEURODEGENERATIVE DISEASES
  • Pharmacology & Pharmacy
  • Physical Sciences
  • Science & Technology

Digital Object Identifier (DOI)

publisher

  • PERGAMON-ELSEVIER SCIENCE LTD

start page

  • 1143

end page

  • 1152

volume

  • 25

issue

  • 3