Mechanotransductive stabilization of HIF-1α is inhibited by mitochondrial antioxidant therapy in the setting of pulmonary overcirculation Article

Boehme, Jason T, Datar, Sanjeev A, Sun, Xutong et al. (2025). Mechanotransductive stabilization of HIF-1α is inhibited by mitochondrial antioxidant therapy in the setting of pulmonary overcirculation . SCIENTIFIC REPORTS, 15(1), 10.1038/s41598-025-99062-0

Open Access

cited authors

  • Boehme, Jason T; Datar, Sanjeev A; Sun, Xutong; Gong, Wenhui; Lu, Qing; Soto, Jamie; Smith, Michael A; Garcia-Flores, Alejandro E; Raff, Gary W; Wang, Ting; Maltepe, Emin; Black, Stephen M; Fineman, Jeffrey R

sustainable development goals

authors

publication date

  • May 10, 2025

published in

keywords

  • ARTERIAL-HYPERTENSION
  • BLOOD-FLOW
  • Congenital heart disease
  • ENDOTHELIAL FUNCTION
  • FISSION
  • HIF-1 alpha
  • LAMB MODEL
  • Mechanotransduction
  • Mitochondrial ROS
  • Multidisciplinary Sciences
  • NITRIC-OXIDE SYNTHASE
  • Nitric oxide
  • PRESERVES
  • Pulmonary hypertension
  • REDOX HOMEOSTASIS
  • Science & Technology
  • Science & Technology - Other Topics

Digital Object Identifier (DOI)

publisher

  • NATURE PORTFOLIO

volume

  • 15

issue

  • 1