FIU Discovery

Mitochondrial hyperfusion induces metabolic remodeling in lung endothelial cells by modifying the activities of electron transport chain complexes I and III.  FREE RADICAL BIOLOGY AND MEDICINE.  210:183-194.

Simvastatin restores pulmonary endothelial function in the setting of pulmonary over-circulation.  NITRIC OXIDE-BIOLOGY AND CHEMISTRY.  142:58-68.

Novel Relationship between Mitofusin 2-Mediated Mitochondrial Hyperfusion, Metabolic Remodeling, and Glycolysis in Pulmonary Arterial Endothelial Cells

Endothelin-1 acutely increases nitric oxide production via the calcineurin mediated dephosphorylation of Caveolin-1.  NITRIC OXIDE-BIOLOGY AND CHEMISTRY.  140:50-57.

Sphingosine-1-Phosphate Receptor 3 Induces Endothelial Barrier Loss via ADAM10-Mediated Vascular Endothelial-Cadherin Cleavage

SOX17 Deficiency Mediates Pulmonary Hypertension At the Crossroads of Sex, Metabolism, and Genetics.  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.  207:1055-1069.

Nitration-mediated activation of the small GTPase RhoA stimulates cellular glycolysis through enhanced mitochondrial fission

Loss of SOX18/CLAUDIN5 disrupts the pulmonary endothelial barrier in ventilator-induced lung injury

Abstract 13625: Autophagy Plays a Key Role in the Loss of Nitric Oxide Signaling and Endothelial Dysfunction in Pulmonary Vascular Diseases.  CIRCULATION.  146:a13625-a13625.

Abstract 14973: Upregulated Sphingosine-1-Phosphate Receptor 3 Disrupts Endothelial Cell Barrier and Mitochondrial Network Dynamics.  CIRCULATION.  146:a14973-a14973.

Nitration of protein kinase G-I alpha modulates cyclic nucleotide crosstalk via phosphodiesterase 3A: Implications for acute lung injury

Arginine recycling in endothelial cells is regulated BY HSP90 and the ubiquitin proteasome system.  NITRIC OXIDE-BIOLOGY AND CHEMISTRY.  108:12-19.

The mitochondrial redistribution of eNOS is involved in lipopolysaccharide induced inflammasome activation during acute lung injury.  REDOX BIOLOGY.  41.

Activation of the mechanosensitive Ca2+ channel TRPV4 induces endothelial barrier permeability via the disruption of mitochondrial bioenergetics.  REDOX BIOLOGY.  38.

RAC1 nitration at Y-32 IS involved in the endothelial barrier disruption associated with lipopolysaccharide-mediated acute lung injury.  REDOX BIOLOGY.  38.

TGF-beta 1 attenuates mitochondrial bioenergetics in pulmonary arterial endothelial cells via the disruption of carnitine homeostasis.  REDOX BIOLOGY.  36.

Biomechanical Forces and Oxidative Stress: Implications for Pulmonary Vascular Disease.  ANTIOXIDANTS & REDOX SIGNALING.  31:819-842.

Microvascular capillary assessment in relation to forearm blood flow

Ovine Models of Congenital Heart Disease and the Consequences of Hemodynamic Alterations for Pulmonary Artery Remodeling.  AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY.  60:503-514.

LPS-induced Acute Lung Injury Involves NF-kappa B-mediated Downregulation of SOX18.  AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY.  58:614-624.

Hyper-activation of pp60(Src) limits nitric oxide signaling by increasing asymmetric dimethylarginine levels during acute lung injury.  FREE RADICAL BIOLOGY AND MEDICINE.  102:217-228.

Neuroprotective and Functional Improvement Effects of Methylene Blue in Global Cerebral Ischemia.  MOLECULAR NEUROBIOLOGY.  53:5344-5355.

Asymmetric Dimethylarginine Stimulates Akt1 Phosphorylation via Heat Shock Protein 70-Facilitated Carboxyl-Terminal Modulator Protein Degradation in Pulmonary Arterial Endothelial Cells.  AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY.  55:275-287.

Autophagy in neonatal hypoxia ischemic brain is associated with oxidative stress.  REDOX BIOLOGY.  6:516-523.

Nitric oxide induces hypoxia ischemic injury in the neonatal brain via the disruption of neuronal iron metabolism.  REDOX BIOLOGY.  6:112-121.

Endothelin-1 Induces a Glycolytic Switch in Pulmonary Arterial Endothelial Cells via the Mitochondrial Translocation of Endothelial Nitric Oxide Synthase.  AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY.  50:1084-1095.

Dimethylarginine Dimethylaminohydrolase II Overexpression Attenuates LPS-Mediated Lung Leak in Acute Lung Injury.  AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY.  50:614-625.

Ca2+/Calmodulin-Dependent Protein Kinase II Contributes to Hypoxic Ischemic Cell Death in Neonatal Hippocampal Slice Cultures.  PLOS ONE.  8.

Disruption of Endothelial Cell Mitochondrial Bioenergetics in Lambs with Increased Pulmonary Blood Flow.  ANTIOXIDANTS & REDOX SIGNALING.  18:1739-1752.

Rosiglitazone preserves pulmonary vascular function in lambs with increased pulmonary blood flow.  PEDIATRIC RESEARCH.  73:54-61.

Groundwater Contaminated with Hexavalent Chromium [Cr (VI)]: A Health Survey and Clinical Examination of Community Inhabitants (Kanpur, India).  PLOS ONE.  7.

Increased NADPH oxidase-derived superoxide is involved in the neuronal cell death induced by hypoxia-ischemia in neonatal hippocampal slice cultures.  FREE RADICAL BIOLOGY AND MEDICINE.  53:1139-1151.

Glutathione supplementation attenuates lipopolysaccharide-induced mitochondrial dysfunction and apoptosis in a mouse model of acute lung injury.  FRONTIERS IN PHYSIOLOGY.  3.

Increased p38 mitogen-activated protein kinase signaling is involved in the oxidative stress associated with oxygen and glucose deprivation in neonatal hippocampal slice cultures

Delineating the angiogenic gene expression profile before pulmonary vascular remodeling in a lamb model of congenital heart disease

A novel role for caveolin-1 in regulating endothelial nitric oxide synthase activation in response to H2O2 and shear stress.  FREE RADICAL BIOLOGY AND MEDICINE.  49:159-170.

ROS Signaling in the Pathogenesis of Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS).  105-137.

The Mitochondrial Redistribution of eNOS is involved in Lipopolysaccharide Induced Inflammasome Activation During Acute Lung Injury.  FREE RADICAL BIOLOGY AND MEDICINE. S101-S101.

Histone Deacetylases 1 and 2 Play Essential Roles in the Lipopolysaccharide (LPS) Dependent Disruption of the Endothelial Barrier via the Repression of the Transcription Factor Sox18.  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.

Cyclic stretch-induced eNOS translocation to the mitochondrion induces mitochondrial dysfunction and oxidative stress in pulmonary artery endothelial cells.  FREE RADICAL BIOLOGY AND MEDICINE. S45-S45.

The tyrosine nitration of PKG-1 alpha inhibits its regulatory function in the pulmonary endothelium.  FREE RADICAL BIOLOGY AND MEDICINE. S46-S46.

Increased NADPH Oxidase Derived Superoxide is Involved in Hypoxia Ischemic Neuronal Cell Death in Neonatal Hippocampal Slice Cultures.  FREE RADICAL BIOLOGY AND MEDICINE. S156-S156.

Aging and surface instability in high-Tc superconductors.  ADVANCED BIOMEDICAL AND CLINICAL DIAGNOSTIC SYSTEMS VII. 26-33.

Targeting the mitochondrial fission-mediator Drp1 is a potential therapeutic strategy for ventilator induced lung injury.  FREE RADICAL BIOLOGY AND MEDICINE. S94-S94.

Mitochondrial Hyperfusion Disrupts Carbohydrate Metabolism In Lung Endothelial Cells By Modifying The Activities Of Electron Transport Chain Complexes I And III.  FREE RADICAL BIOLOGY AND MEDICINE.

Mitochondrial redistribution of eNOS is regulated by CHIP mediated disruption of Dimerization.  FREE RADICAL BIOLOGY AND MEDICINE.

NAMPT induces Mitochondrial and Barrier Dysfunction in Pulmonary Endothelial Cells.  FREE RADICAL BIOLOGY AND MEDICINE.

The anti-apoptotic protein, Survivin induces a shift in endothelial cell in carbon metabolism through a mitochondrial-ROS-dependent increase in HIF-1a signaling.  FREE RADICAL BIOLOGY AND MEDICINE.

Autophagy plays a key role in hyper-proliferative phenotype in pulmonary vascular diseases.  FREE RADICAL BIOLOGY AND MEDICINE. 52-52.

Increased Mitochondrial Fission Induces a Warburg Phenotype Via the Hydrogen Peroxide Mediated inhibition of Prolyl Hydroxylase 2 (PHD2) in Pulmonary Arterial Endothelial Cells.  FREE RADICAL BIOLOGY AND MEDICINE. 100-100.

Mitochondrial Fission Drives A Glycolytic Endothelial Phenotype In Pulmonary Hypertension: Role Of Nitrated RhoA.  FREE RADICAL BIOLOGY AND MEDICINE. 49-49.

Role Of Mitochondrial ROS and HIF Signaling in the Metabolic Reprogramming Associated with Increased Sox18 Expression.  FREE RADICAL BIOLOGY AND MEDICINE. 56-57.

VILI Induced Nitration of RhoA Disrupts Mitochondrial Function Through Increased Generation of Reactive Oxygen Species.  FREE RADICAL BIOLOGY AND MEDICINE. 46-46.

Iron metabolism, oxidative stress, and neonatal brain injury.  725-726.

Erratum: Rosiglitazone preserves pulmonary vascular function in lambs with increased pulmonary blood flow (Pediatric Research (2013) 73 (54-61) DOI: 10.1038/pr.2012.149).  PEDIATRIC RESEARCH. 742.

Complex interplay between autophagy and oxidative stress in the development of pulmonary disease.  REDOX BIOLOGY.