FIU Discovery

Hemolysis-induced Lung Vascular Leakage Contributes to the Development of Pulmonary Hypertension.  American Journal of Respiratory Cell and Molecular Biology.  59:334-345.

Protective effect of adenosine receptors against lipopolysaccharide-induced acute lung injury.  American Journal of Physiology - Lung Cellular and Molecular Physiology.  306:L497-L507.

The leading role of microtubules in endothelial barrier dysfunction: Disassembly of peripheral microtubules leaves behind the cytoskeletal reorganization.  Journal of Cellular Biochemistry.  114:2258-2272.

Arginase 1: An unexpected mediator of pulmonary capillary barrier dysfunction in models of acute lung injury.  Frontiers in Immunology.  4.

Putative protein partners for the human CPI-17 protein revealed by bacterial two-hybrid screening.  Microvascular Research.  88:19-24.

Protein kinase C-α and arginase I mediate pneumolysin-induced pulmonary endothelial hyperpermeability.  American Journal of Respiratory Cell and Molecular Biology.  47:445-453.

Tissue transglutaminase promotes PDGF/PDGFR-mediated signaling and responses in vascular smooth muscle cells.  Journal of Cellular Physiology.  227:2089-2096.

Agonist of growth hormone-releasing hormone reduces pneumolysin-induced pulmonary permeability edema.  Proceedings of the National Academy of Sciences of the United States of America.  109:2084-2089.

Abstract 18331: Microvascular Thrombosis Increases Pro-inflammatory Gr-1(+) Cd11b(+) Myeloid Cells Activation and Promotes Endothelial Barrier Disruption.  Circulation.  124.

Unconventional secretion of tissue transglutaminase involves phospholipid-dependent delivery into recycling endosomes.  PLoS ONE.  6.

P2Y receptors as regulators of lung endothelial barrier integrity.  Journal of Cardiovascular Disease Research.  2:14-22.

Extracellular β-nicotinamide adenine dinucleotide (β-NAD) promotes the endothelial cell barrier integrity via PKA- and EPAC1/Rac1-dependent actin cytoskeleton rearrangement.  Journal of Cellular Physiology.  223:215-223.

Regulation of platelet-derived growth factor receptor function by integrin-associated cell surface transglutaminase.  Journal of Biological Chemistry.  284:16693-16703.

Cell-surface transglutaminase undergoes internalization and lysosomal degradation: An essential role for LRP1.  Journal of Cell Science.  120:3188-3199.

Cell surface transglutaminase promotes RhoA activation via integrin clustering and suppression of the Src-p190RhoGAP signaling pathway.  Molecular Biology of the Cell.  17:1606-1619.

Identification of a novel recognition sequence for fibronectin within the NH2-terminal β-sandwich domain of tissue transglutaminase.  Journal of Biological Chemistry.  280:23675-23683.

Transglutaminase-mediated oligomerization of the fibrin(ogen) αC domains promotes integrin-dependent cell adhesion and signaling.  Blood.  105:3561-3568.

Cell-surface-associated tissue transglutaminase is a target of MMP-2 proteolysis.  Biochemistry.  43:11760-11769.

Pro-apoptotic protein kinase Cδ is associated with intranuclear inclusions in a transgenic model of Huntington's disease.  Journal of Neurochemistry.  87:395-406.

Impaired degradation of PKCα by proteasome in a cellular model of Huntington's disease.  NeuroReport.  14:1435-1438.

Interaction of Bombyx mori nucleopolyhedrovirus BRO-A and host cell protein laminin.  Archives of Virology.  148:99-113.

Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release.  Human Molecular Genetics.  10:1049-1059.

Evidence for nucleic acid binding ability and nucleosome association of Bombyx Mori nucleopolyhedrovirus BRO proteins.  Journal of Virology.  74:6784-6789.

Characterization of baculovirus repeated open reading frames (bro) in Bombyx mori nucleopolyhedrovirus.  Journal of Virology.  73:10339-10345.

Casein kinase activity during early development of loach (Misgurnus fossilis L.).  Biology Bulletin.  25:182-185.

Protein kinase C and casein kinase 2 phosphorylate in vitro proteins of the annexin family from eggs of loach Misgurnus fossilis.  Biochemistry (Moscow).  63:1074-1077.

Effect of "decreasing of sensitivity" to heparin of casein kinase II type (CK II) in early development of loach Misgurnus fossilis L..  International Journal of Developmental Biology.  Suppl 1.

Induction of a novel protein kinase in pupae of the silkworm Bombyx mori after infection with nuclear polyhedrosis virus.  Journal of General Virology.  73:3231-3234.

Protein synthesis in pupae of the silkworm Bombyx mori after infection with nuclear polyhedrosis virus: Resistance to viral infection acquired during pupal period.  Journal of General Virology.  73:3195-3202.

Extracellular purines in endothelial cell barrier regulation.  39-55.

PKG REGULATES PDE3A ACTIVATION THROUGH MODULATING ITS INTERACTION WITH HSP90.  Journal of Investigative Medicine. 1111-1112.

Activation of the Mechanoreceptor, TRPV4 is Sufficient to Induce a ROS-dependent Inflammatory Response in Pulmonary Endothelial Cells.  Free Radical Biology and Medicine. S128-S128.

Differential Effects of Biomechanical Forces on Endothelial Bioenergetics: Role of eNOS Mitochondrial Redistribution.  Free Radical Biology and Medicine. S115-S115.

Mitochondrial Derived Hydrogen Peroxide Results in an Increase in Aerobic Glycolysis in Pulmonary Endothelial Cells via the Activation of HIF-1a Through Disulfide Bond-mediated PHD2 Dimerization.  Free Radical Biology and Medicine. S128-S128.

The Mitochondrial Redistribution of Uncoupled eNOS is Involved in the LPS-induced Activation of the Inflammasome in Pulmonary Endothelial Cells.  Free Radical Biology and Medicine. S94-S95.

Free Heme-Mediated Endothelial Barrier Dysfunction Contributes to the Development of Pulmonary Hypertension.  American Journal of Respiratory and Critical Care Medicine.

Tyrosine Nitration of Protein Kinase G-1a Disrupts Cyclic Nucleotide Cross-Talk and Is Involved in the Development of Acute Lung Injury.  American Journal of Respiratory and Critical Care Medicine.

Heme-Driven ROS Production Leads to Increased P38 MAP Kinase Activity and Endothelial Barrier.  Free Radical Biology and Medicine. S149-S150.

Growth Hormone Releasing Hormone Agonist Protects From Pneumolysin-Induced Pulmonary Permeability.  a3664-a3664.

The Effect Of Adenosine Compared To A2A Agonist, CGS 21680 In Wild Type Control And A2A Receptor (A2AR) Knock Out Murine Model Of Acute Lung Injury.  a2114-a2114.

Mini-review: Novel therapeutic strategies to blunt actions of pneumolysin in the lungs.  Toxins. 1244-1260.

The role of tissue transglutaminase in cell-matrix interactions.  Frontiers in Bioscience - Landmark. 1057-1076.