FIU Discovery

The Pulmonary Endothelial Glycocalyx Modifications in Glypican 1 Knockout Mice Do Not Affect Lung Endothelial Function in Physiological Conditions.  International Journal of Molecular Sciences.  24.

Nitration-mediated activation of the small GTPase RhoA stimulates cellular glycolysis through enhanced mitochondrial fission.  JOURNAL OF BIOLOGICAL CHEMISTRY.  299.

Loss of SOX18/CLAUDIN5 disrupts the pulmonary endothelial barrier in ventilator-induced lung injury.  Frontiers in Physiology.  13.

Abstract 13625: Autophagy Plays a Key Role in the Loss of Nitric Oxide Signaling and Endothelial Dysfunction in Pulmonary Vascular Diseases.  CIRCULATION.  146:a13625-a13625.

Abstract 15352: Lung Endothelial Transport in Glypican 1 Knockout Mice.  CIRCULATION.  146:a15352-a15352.

NF-κB-dependent repression of Sox18 transcription factor requires the epigenetic regulators histone deacetylases 1 and 2 in acute lung injury.  Frontiers in Physiology.  13.

Abstract 13551: RhoA Mediates Pressure-Induced Endothelial Hyperpermeability.  CIRCULATION.  144:a13551-a13551.

Nitration of protein kinase G-Iα modulates cyclic nucleotide crosstalk via phosphodiesterase 3A: Implications for acute lung injury.  Journal of Biological Chemistry.  297.

The mitochondrial redistribution of eNOS is involved in lipopolysaccharide induced inflammasome activation during acute lung injury.  REDOX BIOLOGY.  41.

Activation of the mechanosensitive Ca²⁺ channel TRPV4 induces endothelial barrier permeability via the disruption of mitochondrial bioenergetics.  REDOX BIOLOGY.  38.

Biomechanical Forces and Oxidative Stress: Implications for Pulmonary Vascular Disease.  ANTIOXIDANTS & REDOX SIGNALING.  31:819-842.

Hemolysis-induced Lung Vascular Leakage Contributes to the Development of Pulmonary Hypertension.  AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY.  59:334-345.

LPS-induced Acute Lung Injury Involves NF-κB-mediated Downregulation of SOX18.  AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY.  58:614-624.

Hyper-activation of pp60^Src limits nitric oxide signaling by increasing asymmetric dimethylarginine levels during acute lung injury.  FREE RADICAL BIOLOGY AND MEDICINE.  102:217-228.

Low anticoagulant heparin blocks thrombin-induced endothelial permeability in a PAR-dependent manner.  Vascular Pharmacology.  62:63-71.

Protective effect of adenosine receptors against lipopolysaccharide-induced acute lung injury.  AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY.  306:L497-L507.

The leading role of microtubules in endothelial barrier dysfunction: Disassembly of peripheral microtubules leaves behind the cytoskeletal reorganization.  JOURNAL OF CELLULAR BIOCHEMISTRY.  114:2258-2272.

Arginase 1: An unexpected mediator of pulmonary capillary barrier dysfunction in models of acute lung injury.  FRONTIERS IN IMMUNOLOGY.  4.

Putative protein partners for the human CPI-17 protein revealed by bacterial two-hybrid screening.  Microvascular Research.  88:19-24.

Protein kinase C-α and arginase I mediate pneumolysin-induced pulmonary endothelial hyperpermeability.  AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY.  47:445-453.

Tissue transglutaminase promotes PDGF/PDGFR-mediated signaling and responses in vascular smooth muscle cells.  Journal of Cellular Physiology.  227:2089-2096.

Agonist of growth hormone-releasing hormone reduces pneumolysin-induced pulmonary permeability edema.  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.  109:2084-2089.

Abstract 18331: Microvascular Thrombosis Increases Pro-inflammatory Gr-1(+) Cd11b(+) Myeloid Cells Activation and Promotes Endothelial Barrier Disruption.  CIRCULATION.  124.

Unconventional secretion of tissue transglutaminase involves phospholipid-dependent delivery into recycling endosomes.  PLOS ONE.  6.

P2Y receptors as regulators of lung endothelial barrier integrity.  Journal of Cardiovascular Disease Research.  2:14-22.

Extracellular β-nicotinamide adenine dinucleotide (β-NAD) promotes the endothelial cell barrier integrity via PKA- and EPAC1/Rac1-dependent actin cytoskeleton rearrangement.  Journal of Cellular Physiology.  223:215-223.

Microtubules Growth Rate Alteration in Human Endothelial Cells.  Journal of Biomedicine and Biotechnology. 

Regulation of platelet-derived growth factor receptor function by integrin-associated cell surface transglutaminase.  JOURNAL OF BIOLOGICAL CHEMISTRY.  284:16693-16703.

Cell-surface transglutaminase undergoes internalization and lysosomal degradation: An essential role for LRP1.  Journal of Cell Science.  120:3188-3199.

Cell surface transglutaminase promotes RhoA activation via integrin clustering and suppression of the Src-p190RhoGAP signaling pathway.  MOLECULAR BIOLOGY OF THE CELL.  17:1606-1619.

Identification of a novel recognition sequence for fibronectin within the NH2-terminal β-sandwich domain of tissue transglutaminase.  JOURNAL OF BIOLOGICAL CHEMISTRY.  280:23675-23683.

Transglutaminase-mediated oligomerization of the fibrin(ogen) αC domains promotes integrin-dependent cell adhesion and signaling.  BLOOD.  105:3561-3568.

Cell-surface-associated tissue transglutaminase is a target of MMP-2 proteolysis.  BIOCHEMISTRY.  43:11760-11769.

Pro-apoptotic protein kinase Cδ is associated with intranuclear inclusions in a transgenic model of Huntington's disease.  JOURNAL OF NEUROCHEMISTRY.  87:395-406.

Impaired degradation of PKCα by proteasome in a cellular model of Huntington's disease.  NeuroReport.  14:1435-1438.

Interaction of Bombyx mori nucleopolyhedrovirus BRO-A and host cell protein laminin.  ARCHIVES OF VIROLOGY.  148:99-113.

Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release.  Human Molecular Genetics.  10:1049-1059.

Evidence for nucleic acid binding ability and nucleosome association of Bombyx Mori nucleopolyhedrovirus BRO proteins.  Journal of Virology.  74:6784-6789.

Characterization of baculovirus repeated open reading frames (bro) in Bombyx mori nucleopolyhedrovirus.  Journal of Virology.  73:10339-10345.

Casein kinase activity during early development of loach (Misgurnus fossilis L.).  Biology Bulletin.  25:182-185.

Protein kinase C and casein kinase 2 phosphorylate in vitro proteins of the annexin family from eggs of loach Misgurnus fossilis.  Biochemistry (Moscow).  63:1074-1077.

Effect of "decreasing of sensitivity" to heparin of casein kinase II type (CK II) in early development of loach Misgurnus fossilis L..  International Journal of Developmental Biology.  Suppl 1.

Induction of a novel protein kinase in pupae of the silkworm Bombyx mori after infection with nuclear polyhedrosis virus.  Journal of General Virology.  73:3231-3234.

Protein synthesis in pupae of the silkworm Bombyx mori after infection with nuclear polyhedrosis virus: Resistance to viral infection acquired during pupal period.  Journal of General Virology.  73:3195-3202.

Molecular mechanisms involved in adenosine-induced endothelial cell barrier enhancement.  Vascular Pharmacology.  52:199-206.

ROS Signaling in the Pathogenesis of Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS).  105-137.

Extracellular purines in endothelial cell barrier regulation.  39-55.

The Mitochondrial Redistribution of eNOS is involved in Lipopolysaccharide Induced Inflammasome Activation During Acute Lung Injury.  FREE RADICAL BIOLOGY AND MEDICINE. S101-S101.

PKG REGULATES PDE3A ACTIVATION THROUGH MODULATING ITS INTERACTION WITH HSP90.  JOURNAL OF INVESTIGATIVE MEDICINE. 1111-1112.

Activation of the Mechanoreceptor, TRPV4 is Sufficient to Induce a ROS-dependent Inflammatory Response in Pulmonary Endothelial Cells.  FREE RADICAL BIOLOGY AND MEDICINE. S128-S128.

Differential Effects of Biomechanical Forces on Endothelial Bioenergetics: Role of eNOS Mitochondrial Redistribution.  FREE RADICAL BIOLOGY AND MEDICINE. S115-S115.

Mitochondrial Derived Hydrogen Peroxide Results in an Increase in Aerobic Glycolysis in Pulmonary Endothelial Cells via the Activation of HIF-1a Through Disulfide Bond-mediated PHD2 Dimerization.  FREE RADICAL BIOLOGY AND MEDICINE. S128-S128.

The Mitochondrial Redistribution of Uncoupled eNOS is Involved in the LPS-induced Activation of the Inflammasome in Pulmonary Endothelial Cells.  FREE RADICAL BIOLOGY AND MEDICINE. S94-S95.

Histone Deacetylases 1 and 2 Play Essential Roles in the Lipopolysaccharide (LPS) Dependent Disruption of the Endothelial Barrier via the Repression of the Transcription Factor Sox18.  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.

Cyclic stretch-induced eNOS translocation to the mitochondrion induces mitochondrial dysfunction and oxidative stress in pulmonary artery endothelial cells.  FREE RADICAL BIOLOGY AND MEDICINE. S45-S45.

The tyrosine nitration of PKG-1 alpha inhibits its regulatory function in the pulmonary endothelium.  FREE RADICAL BIOLOGY AND MEDICINE. S46-S46.

Free Heme-Mediated Endothelial Barrier Dysfunction Contributes to the Development of Pulmonary Hypertension.  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.

Tyrosine Nitration of Protein Kinase G-1a Disrupts Cyclic Nucleotide Cross-Talk and Is Involved in the Development of Acute Lung Injury.  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.

Heme-Driven ROS Production Leads to Increased P38 MAP Kinase Activity and Endothelial Barrier.  FREE RADICAL BIOLOGY AND MEDICINE. S149-S150.

Growth Hormone Releasing Hormone Agonist Protects from Pneumolysin-Induced Pulmonary Permeability.  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. a3664-a3664.

The Effect of Adenosine Compared to A2A Agonist, CGS 21680 in Wild Type Control and A2A Receptor (A2AR) Knock Out Murine Model of Acute Lung Injury.  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. a2114-a2114.

APE1/Ref-1 is a Novel Redox-Sensitive Element of Lipopolysaccharide-Induced NF-κB-dependent Inflammatory Response in a Cellular Model of Acute Lung Injury.  FREE RADICAL BIOLOGY AND MEDICINE. S11-S12.

Systemic effect of NF-kB-mediated Signaling Pathway Induced by Mechanosensitive Ca2+-Channel TRPV4 in Pulmonary Endothelial Cells.  FREE RADICAL BIOLOGY AND MEDICINE.

The anti-apoptotic protein, Survivin induces a shift in endothelial cell in carbon metabolism through a mitochondrial-ROS-dependent increase in HIF-1a signaling.  FREE RADICAL BIOLOGY AND MEDICINE.

Autophagy plays a key role in hyper-proliferative phenotype in pulmonary vascular diseases.  FREE RADICAL BIOLOGY AND MEDICINE. 52-52.

Nitration-Mediated PKG-1alpha Inhibition Disrupts Proteasome-dependent Degradation of PDE3A.  FREE RADICAL BIOLOGY AND MEDICINE. 57-57.

Complex interplay between autophagy and oxidative stress in the development of pulmonary disease.  REDOX BIOLOGY.

Endothelial cell signaling and ventilator-induced lung injury: molecular mechanisms, genomic analyses, and therapeutic targets.  AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. L452-L476.

Mini-review: Novel therapeutic strategies to blunt actions of pneumolysin in the lungs.  Toxins. 1244-1260.

The role of tissue transglutaminase in cell-matrix interactions.  Frontiers in Bioscience - Landmark. 1057-1076.