Zemskov, Evgeny Graduate Faculty
- Associate Professor, Cellular and Molecular Medicine , Herbert Wertheim College of Medicine
Overview
biography
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Evgeny A. Zemskov, PhD, is an associate professor at the Center for Translational Science and Department of Cellular Biology and Pharmacology. Dr. Zemskov joined HWCOM in 2021. He is involved in biomedical translational research related to lung pathologies.
His research interests include investigating the molecular mechanisms of vascular hyperpermeability in acute lung injury (ALI) and ventilator-induced lung injury (VILI), as well as approaches to protect the barrier function of pulmonary endothelium and endothelial integrity. Dr. Zemskov has co-authored more than 50 research papers and review articles. Results of his research have been presented at numerous national and international scientific conferences
research interests
- Biochemistry, Cellular and Molecular Biology.
Scholarly & Creative Works
selected scholarly works & creative activities
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Article
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2023Nitration-mediated activation of the small GTPase RhoA stimulates cellular glycolysis through enhanced mitochondrial fissionFull Text via DOI: 10.1016/j.jbc.2023.103067 Web of Science: 001006729100001
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2022Loss of SOX18/CLAUDIN5 disrupts the pulmonary endothelial barrier in ventilator-induced lung injuryFull Text via DOI: 10.3389/fphys.2022.1066515 Web of Science: 000907807400001
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2022Abstract 13625: Autophagy Plays a Key Role in the Loss of Nitric Oxide Signaling and Endothelial Dysfunction in Pulmonary Vascular Diseases. CIRCULATION. 146:a13625-a13625.Full Text via DOI: 10.1161/circ.146.suppl_1.13625
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2022Abstract 15352: Lung Endothelial Transport in Glypican 1 Knockout Mice. CIRCULATION. 146:a15352-a15352.Full Text via DOI: 10.1161/circ.146.suppl_1.15352
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2021Abstract 13551: RhoA Mediates Pressure-Induced Endothelial Hyperpermeability. CIRCULATION. 144:a13551-a13551.Full Text via DOI: 10.1161/circ.144.suppl_1.13551
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2021The mitochondrial redistribution of eNOS is involved in lipopolysaccharide induced inflammasome activation during acute lung injury. REDOX BIOLOGY. 41.Full Text via DOI: 10.1016/j.redox.2021.101878 Web of Science: 000649744300004
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2021Activation of the mechanosensitive Ca2+ channel TRPV4 induces endothelial barrier permeability via the disruption of mitochondrial bioenergetics. REDOX BIOLOGY. 38.Full Text via DOI: 10.1016/j.redox.2020.101785 Web of Science: 000604901800005
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2019Biomechanical Forces and Oxidative Stress: Implications for Pulmonary Vascular Disease. ANTIOXIDANTS & REDOX SIGNALING. 31:819-842.Full Text via DOI: 10.1089/ars.2018.7720 Web of Science: 000461654200001
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2018Hemolysis-induced Lung Vascular Leakage Contributes to the Development of Pulmonary Hypertension. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY. 59:334-345.Full Text via DOI: 10.1165/rcmb.2017-0308OC Web of Science: 000443438700011
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2018LPS-induced Acute Lung Injury Involves NF-kappa B-mediated Downregulation of SOX18. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY. 58:614-624.Full Text via DOI: 10.1165/rcmb.2016-0390OC Web of Science: 000431198400015
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2017Hyper-activation of pp60(Src) limits nitric oxide signaling by increasing asymmetric dimethylarginine levels during acute lung injury. FREE RADICAL BIOLOGY AND MEDICINE. 102:217-228.Full Text via DOI: 10.1016/j.freeradbiomed.2016.11.008 Web of Science: 000392361200018
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2014Low anticoagulant heparin blocks thrombin-induced endothelial permeability in a PAR-dependent mannerFull Text via DOI: 10.1016/j.vph.2014.01.005 Web of Science: 000340211900003
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2014Protective effect of adenosine receptors against lipopolysaccharide-induced acute lung injury. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. 306.Full Text via DOI: 10.1152/ajplung.00086.2013
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2013The leading role of microtubules in endothelial barrier dysfunction: Disassembly of peripheral microtubules leaves behind the cytoskeletal reorganization. JOURNAL OF CELLULAR BIOCHEMISTRY. 114:2258-2272.Full Text via DOI: 10.1002/jcb.24575
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2013Putative protein partners for the human CPI-17 protein revealed by bacterial two-hybrid screening. MICROVASCULAR RESEARCH. 88:19-24.Full Text via DOI: 10.1016/j.mvr.2013.04.002
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2012Protein kinase C-α and arginase I mediate pneumolysin-induced pulmonary endothelial hyperpermeability. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY. 47:445-453.Full Text via DOI: 10.1165/rcmb.2011-0332OC
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2012Tissue transglutaminase promotes PDGF/PDGFR-mediated signaling and responses in vascular smooth muscle cells. JOURNAL OF CELLULAR PHYSIOLOGY. 227:2089-2096.Full Text via DOI: 10.1002/jcp.22938
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2012Agonist of growth hormone-releasing hormone reduces pneumolysin-induced pulmonary permeability edema. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 109:2084-2089.Full Text via DOI: 10.1073/pnas.1121075109
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2011P2Y receptors as regulators of lung endothelial barrier integrityFull Text via DOI: 10.4103/0975-3583.78582
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2010Extracellular β-nicotinamide adenine dinucleotide (β-NAD) promotes the endothelial cell barrier integrity via PKA- and EPAC1/Rac1-dependent actin cytoskeleton rearrangement. JOURNAL OF CELLULAR PHYSIOLOGY. 223:215-223.Full Text via DOI: 10.1002/jcp.22029
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2010Microtubules Growth Rate Alteration in Human Endothelial CellsFull Text via DOI: 10.1155/2010/671536 Web of Science: 000277804500001
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2009Regulation of platelet-derived growth factor receptor function by integrin-associated cell surface transglutaminase. JOURNAL OF BIOLOGICAL CHEMISTRY. 284:16693-16703.Full Text via DOI: 10.1074/jbc.M109.010769
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2007Cell-surface transglutaminase undergoes internalization and lysosomal degradation: An essential role for LRP1. JOURNAL OF CELL SCIENCE. 120:3188-3199.Full Text via DOI: 10.1242/jcs.010397
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2006Cell surface transglutaminase promotes RhoA activation via integrin clustering and suppression of the Src-p190RhoGAP signaling pathway. MOLECULAR BIOLOGY OF THE CELL. 17:1606-1619.Full Text via DOI: 10.1091/mbc.E05-06-0549
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2005Identification of a novel recognition sequence for fibronectin within the NH
2 -terminal β-sandwich domain of tissue transglutaminase. JOURNAL OF BIOLOGICAL CHEMISTRY. 280:23675-23683.Full Text via DOI: 10.1074/jbc.M503323200 -
2005Transglutaminase-mediated oligomerization of the fibrin(ogen) αC domains promotes integrin-dependent cell adhesion and signaling. BLOOD. 105:3561-3568.Full Text via DOI: 10.1182/blood-2004-10-4089
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2004Cell-surface-associated tissue transglutaminase is a target of MMP-2 proteolysis. BIOCHEMISTRY. 43:11760-11769.Full Text via DOI: 10.1021/bi049266z
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2003Pro-apoptotic protein kinase Cδ is associated with intranuclear inclusions in a transgenic model of Huntington's disease. JOURNAL OF NEUROCHEMISTRY. 87:395-406.Full Text via DOI: 10.1046/j.1471-4159.2003.02002.x
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2003Interaction of Bombyx mori nucleopolyhedrovirus BRO-A and host cell protein laminin. ARCHIVES OF VIROLOGY. 148:99-113.Full Text via DOI: 10.1007/s00705-002-0902-7
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2001Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release. HUMAN MOLECULAR GENETICS. 10:1049-1059.Full Text via DOI: 10.1093/hmg/10.10.1049
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Molecular mechanisms involved in adenosine-induced endothelial cell barrier enhancementFull Text via DOI: 10.1016/j.vph.2009.12.008 Web of Science: 000277447100005
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Book Chapter
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2017ROS Signaling in the Pathogenesis of Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS). 105-137.Full Text via DOI: 10.1007/978-3-319-63245-2_8 Web of Science: 000760151300009
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2010Extracellular purines in endothelial cell barrier regulation. 39-55.Full Text via DOI: 10.1007/978-90-481-3435-9_3
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Conference
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2020The Mitochondrial Redistribution of eNOS is involved in Lipopolysaccharide Induced Inflammasome Activation During Acute Lung Injury. FREE RADICAL BIOLOGY AND MEDICINE. S101-S101.Full Text via DOI: 10.1016/j.freeradbiomed.2020.10.259 Web of Science: 000590930700227
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2020PKG REGULATES PDE3A ACTIVATION THROUGH MODULATING ITS INTERACTION WITH HSP90. JOURNAL OF INVESTIGATIVE MEDICINE. 1111-1112.Full Text via DOI: 10.1136/jim-2020-MW.128 Web of Science: 000582669400144
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2019Activation of the Mechanoreceptor, TRPV4 is Sufficient to Induce a ROS-dependent Inflammatory Response in Pulmonary Endothelial Cells. FREE RADICAL BIOLOGY AND MEDICINE. S128-S128.Full Text via DOI: 10.1016/j.freeradbiomed.2019.10.342 Web of Science: 000496777400322
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2019Differential Effects of Biomechanical Forces on Endothelial Bioenergetics: Role of eNOS Mitochondrial Redistribution. FREE RADICAL BIOLOGY AND MEDICINE. S115-S115.Full Text via DOI: 10.1016/j.freeradbiomed.2019.10.308 Web of Science: 000496777400288
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2019Mitochondrial Derived Hydrogen Peroxide Results in an Increase in Aerobic Glycolysis in Pulmonary Endothelial Cells via the Activation of HIF-1a Through Disulfide Bond-mediated PHD2 Dimerization. FREE RADICAL BIOLOGY AND MEDICINE. S128-S128.Full Text via DOI: 10.1016/j.freeradbiomed.2019.10.341 Web of Science: 000496777400321
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2019The Mitochondrial Redistribution of Uncoupled eNOS is Involved in the LPS-induced Activation of the Inflammasome in Pulmonary Endothelial Cells. FREE RADICAL BIOLOGY AND MEDICINE. S94-S95.Full Text via DOI: 10.1016/j.freeradbiomed.2019.10.252 Web of Science: 000496777400234
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2019Histone Deacetylases 1 and 2 Play Essential Roles in the Lipopolysaccharide (LPS) Dependent Disruption of the Endothelial Barrier via the Repression of the Transcription Factor Sox18. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.Web of Science: 000466776705117
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2018Cyclic stretch-induced eNOS translocation to the mitochondrion induces mitochondrial dysfunction and oxidative stress in pulmonary artery endothelial cells. FREE RADICAL BIOLOGY AND MEDICINE. S45-S45.Full Text via DOI: 10.1016/j.freeradbiomed.2018.10.073 Web of Science: 000449083900096
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2018The tyrosine nitration of PKG-1 alpha inhibits its regulatory function in the pulmonary endothelium. FREE RADICAL BIOLOGY AND MEDICINE. S46-S46.Full Text via DOI: 10.1016/j.freeradbiomed.2018.10.074 Web of Science: 000449083900097
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2018Free Heme-Mediated Endothelial Barrier Dysfunction Contributes to the Development of Pulmonary Hypertension. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.Web of Science: 000449978905453
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2018Tyrosine Nitration of Protein Kinase G-1a Disrupts Cyclic Nucleotide Cross-Talk and Is Involved in the Development of Acute Lung Injury. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.Web of Science: 000449978902072
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2016Heme-Driven ROS Production Leads to Increased P38 MAP Kinase Activity and Endothelial Barrier. FREE RADICAL BIOLOGY AND MEDICINE. S149-S150.Full Text via DOI: 10.1016/j.freeradbiomed.2016.10.393 Web of Science: 000444355800353
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2012Growth Hormone Releasing Hormone Agonist Protects From Pneumolysin-Induced Pulmonary Permeability. a3664-a3664.Full Text via DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a3664
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Other Scholarly Work
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2023APE1/Ref-1 is a Novel Redox-Sensitive Element of Lipopolysaccharide-Induced NF-κB-dependent Inflammatory Response in a Cellular Model of Acute Lung Injury. FREE RADICAL BIOLOGY AND MEDICINE. S11-S12.Full Text via DOI: 10.1016/j.freeradbiomed.2023.10.026 Web of Science: 001098825800017
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2022Systemic effect of NF-kB-mediated Signaling Pathway Induced by Mechanosensitive Ca2+-Channel TRPV4 in Pulmonary Endothelial Cells. FREE RADICAL BIOLOGY AND MEDICINE.Full Text via DOI: 10.1016/j.freeradbiomed.2022.10.089 Web of Science: 000895512500099
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2022The anti-apoptotic protein, Survivin induces a shift in endothelial cell in carbon metabolism through a mitochondrial-ROS-dependent increase in HIF-1a signaling. FREE RADICAL BIOLOGY AND MEDICINE.Full Text via DOI: 10.1016/j.freeradbiomed.2022.10.109 Web of Science: 000895512500119
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2022Autophagy plays a key role in hyper-proliferative phenotype in pulmonary vascular diseases. FREE RADICAL BIOLOGY AND MEDICINE. 52-52.Full Text via DOI: 10.1016/j.freeradbiomed.2021.12.113 Web of Science: 000778588700098
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2022Nitration-Mediated PKG-1alpha Inhibition Disrupts Proteasome-dependent Degradation of PDE3A. FREE RADICAL BIOLOGY AND MEDICINE. 57-57.Full Text via DOI: 10.1016/j.freeradbiomed.2021.12.126 Web of Science: 000778588700111
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Review
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2020Complex interplay between autophagy and oxidative stress in the development of pulmonary disease. REDOX BIOLOGY.Full Text via DOI: 10.1016/j.redox.2020.101679 Web of Science: 000571097100003
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2017Endothelial cell signaling and ventilator-induced lung injury: molecular mechanisms, genomic analyses, and therapeutic targets. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. L452-L476.Full Text via DOI: 10.1152/ajplung.00231.2016 Web of Science: 000397870600002
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2013Mini-review: Novel therapeutic strategies to blunt actions of pneumolysin in the lungs. TOXINS. 1244-1260.Full Text via DOI: 10.3390/toxins5071244
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2006The role of tissue transglutaminase in cell-matrix interactions. 1057-1076.Full Text via DOI: 10.2741/1863
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Contact
full name
- Evgeny Zemskov
Identifiers
ORCID iD
- https://orcid.org/0000-0001-6785-9248 (confirmed)
