Tempest, Helen

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Tempest, Helen

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selected scholarly works & creative activities

Article
- 2020
  
  A case for written examinations in undergraduate medical education: experiences with modified essay examinations. Assessment & Evaluation in Higher Education. 45:926-939.
  Full Text via DOI: 10.1080/02602938.2020.1714543 Web of Science: 000509187200001
- 2019
  
  Evaluation of the Major Steps in the Conventional Protocol for the Alkaline Comet Assay. International Journal of Molecular Sciences. 20.
  Full Text via DOI: 10.3390/ijms20236072 Web of Science: 000504428300254
- 2019
  
  Genome-Wide Adductomics Analysis Reveals Heterogeneity in the Induction and Loss of Cyclobutane Thymine Dimers across Both the Nuclear and Mitochondrial Genomes. International Journal of Molecular Sciences. 20.
  Full Text via DOI: 10.3390/ijms20205112 Web of Science: 000498822800144
- 2019
  
  Human Sperm Chromosomes: To Form Hairpin-Loops, Or Not to Form Hairpin-Loops, That Is the Question. Genes. 10.
  Full Text via DOI: 10.3390/genes10070504 Web of Science: 000478636700008
- 2018
  
  The Educational Effects of a Summative Diagnostic Reasoning Examination Among Second-Year Medical Students. Medical Science Educator. 28:667-673.
  Full Text via DOI: 10.1007/s40670-018-0610-x
- 2017
  
  A new model of sperm nuclear architecture following assessment of the organization of centromeres and telomeres in three-dimensions. Scientific Reports. 7.
  Full Text via DOI: 10.1038/srep41585 Web of Science: 000392956200001
- 2016
  
  Design of a Platform to Discuss Ethical Considerations of Preimplantation Genetic Diagnosis: a Case for Integration of Ethics in Foundational Science Medical Curriculum. Medical Science Educator. 26:213-219.
  Full Text via DOI: 10.1007/s40670-016-0234-y
- 2015
  
  Chromosome territory repositioning induced by PHA-activation of lymphocytes: A 2D and 3D appraisal. Molecular Cytogenetics. 8.
  Full Text via DOI: 10.1186/s13039-015-0146-3 Web of Science: 000357252900001
- 2015
  
  Spatial Positioning of All 24 Chromosomes in the Lymphocytes of Six Subjects: Evidence of Reproducible Positioning and Spatial Repositioning following DNA Damage with Hydrogen Peroxide and Ultraviolet B. PLoS ONE. 10.
  Full Text via DOI: 10.1371/journal.pone.0118886 Web of Science: 000351275700029
- 2015
  
  Meiotic Nondisjunction: Insights into the Origin and Significance of Aneuploidy in Human Spermatozoa. Advances in Experimental Medicine and Biology. 868:1-21.
  Full Text via DOI: 10.1007/978-3-319-18881-2_1 Web of Science: 000361813200002
- 2012
  
  Hierarchical radial and polar organisation of chromosomes in human sperm. Chromosome Research. 20:875-887.
  Full Text via DOI: 10.1007/s10577-012-9323-y Web of Science: 000312632500006
- 2011
  
  Meiotic recombination and male infertility: from basic science to clinical reality?. Asian Journal of Andrology. 13:212-218.
  Full Text via DOI: 10.1038/aja.2011.1 Web of Science: 000288074400018
- 2010
  
  Scoring of sperm chromosomal abnormalities by manual and automated approaches: qualitative and quantitative comparisons. Asian Journal of Andrology. 12:257-262.
  Full Text via DOI: 10.1038/aja.2009.85 Web of Science: 000275109700017
- 2009
  
  Comparative genomics in chicken and Pekin duck using FISH mapping and microarray analysis. BMC Genomics. 10.
  Full Text via DOI: 10.1186/1471-2164-10-357 Web of Science: 000269510400001
- 2009
  
  Cytogenetic risks in chromosomally normal infertile men. Current Opinion in Obstetrics and Gynecology. 21:223-227.
  Full Text via DOI: 10.1097/GCO.0b013e32832947c2 Web of Science: 000266576400004
- 2009
  
  Quantum dots as new-generation fluorochromes for FISH: an appraisal. Chromosome Research. 17:519-530.
  Full Text via DOI: 10.1007/s10577-009-9051-0 Web of Science: 000269055300009
- 2009
  
  The use of an e-learning constructivist solution in workplace learning. International Journal of Industrial Ergonomics. 39:548-553.
  Full Text via DOI: 10.1016/j.ergon.2008.10.019
- 2009
  
  Intra-individual and inter-individual variations in sperm aneuploidy frequencies in normal men. Fertility and Sterility. 91:185-192.
  Full Text via DOI: 10.1016/j.fertnstert.2007.11.002 Web of Science: 000262396700027
- 2008
  
  Whole genome comparative studies between chicken and turkey and their implications for avian genome evolution. BMC Genomics. 9.
  Full Text via DOI: 10.1186/1471-2164-9-168 Web of Science: 000255709200001
- 2008
  
  Sperm aneuploidy frequencies analysed before and after chemotherapy in testicular cancer and Hodgkin's lymphoma patients. Human Reproduction. 23:251-258.
  Full Text via DOI: 10.1093/humrep/dem389 Web of Science: 000252544300004
- 2008
  
  The role of sperm aneuploidy as a predictor of the success of intracytoplasmic sperm injection?. Human Reproduction. 23:240-250.
  Full Text via DOI: 10.1093/humrep/dem395 Web of Science: 000252544300003
- 2008
  
  Plants Used in Chinese Medicine for the Treatment of Male Infertility Possess Antioxidant and Anti-Oestrogenic Activity. Systems biology in reproductive medicine. 54:185-195.
  Full Text via DOI: 10.1080/19396360802379073 Web of Science: 000260230900003
- 2007
  
  Practicable approaches to facilitate rapid and accurate molecular cytogenetic mapping in birds and mammals. Cytogenetic and Genome Research. 117:36-42.
  Full Text via DOI: 10.1159/000103163 Web of Science: 000249980800006
- 2007
  
  The evolution of the avian genome as revealed by comparative molecular cytogenetics. Cytogenetic and Genome Research. 117:64-77.
  Full Text via DOI: 10.1159/000103166 Web of Science: 000249980800009
- 2005
  
  Significant reduction of sperm disomy in six men: effect of traditional Chinese medicine?. Asian Journal of Andrology. 7:419-425.
  Full Text via DOI: 10.1111/j.1745-7262.2005.00068.x Web of Science: 000233829600012
- 2004
  
  The association between male infertility and sperm disomy: Evidence for variation in disomy levels among individuals and a correlation between particular semen parameters and disomy of specific chromosome pairs. Reproductive Biology and Endocrinology. 2.
  Full Text via DOI: 10.1186/1477-7827-2-82
- 2004
  
  Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution. Nature. 432:695-716.
  Full Text via DOI: 10.1038/nature03154
- 2004
  
  Molecular cytogenetic definition of the chicken genome: The first complete avian karyotype. Genetics. 166:1367-1373.
  Full Text via DOI: 10.1534/genetics.166.3.1367 Web of Science: 000220950100023
- 2004
  
  The relationship between male infertility and increased levels of sperm disomy. Cytogenetic and Genome Research. 107:83-94.
  Full Text via DOI: 10.1159/000079575 Web of Science: 000224244100014
- 2003
  
  Safety issues in assisted reproduction technology - Should men undergoing ICSI be screened for chromosome abnormalities in their sperm?. Human Reproduction. 18:229-235.
  Full Text via DOI: 10.1093/humrep/deg044 Web of Science: 000181040800001
Book Chapter
- 2013
  
  Interphase cytogenetics at the earliest stages of human development. 123-138.
  Full Text via DOI: 10.1007/978-1-4614-6558-4_7
- 2010
  
  Meiotic Recombination and Errors During Spermatogenesis. 357-365.
  Full Text via DOI: 10.1007/978-1-4419-1436-1_22 Web of Science: 000276968200022
Conference
- 2015
  
  Gene repositioning in human lymphocytes following exposure to genotoxic agents. Chromosome Research. 382-383.
  Web of Science: 000354410600075
- 2015
  
  Male infertility: What role do chromosomes and epigenetic modifications of chromatin play?. Chromosome Research. 355-356.
  Web of Science: 000354410600026
- 2014
  
  A new arrangement for telomere organisation within the human sperm nucleus: implications for fertilization and the developing embryo. Chromosome Research. 603-603.
  Web of Science: 000345967900047
- 2014
  
  GLOBAL TELOMERE ORGANISATION IN THE 3D HUMAN SPERM NUCLEUS: A NEW ARRANGEMENT AND INFERENCES FOR FERTILIZATION AND EMBRYOGENESIS.. Fertility and Sterility. E111-E111.
  Full Text via DOI: 10.1016/j.fertnstert.2014.07.381 Web of Science: 000342500200329
- 2010
  
  Gene density - a determinant of synaptonemal complex length in human males?. Human Reproduction. I147-I148.
  Web of Science: 000279875400360
- 2010
  
  The organisation of the genome in sperm heads of men undergoing chemotherapy for testicular cancer and Hodgkin's lymphoma. Human Reproduction. I71-I71.
  Web of Science: 000279875400173
- 2007
  
  The use of an e-learning constructivist solution in workplace learning. 133-138.
  Full Text via DOI: 10.1145/1362550.1362577
Other Scholarly Work
- 2019
  
  PGDIS Position Statement on the Transfer of Mosaic Embryos 2019. Reproductive BioMedicine Online. E1-E4.
  Full Text via DOI: 10.1016/j.rbmo.2019.06.012 Web of Science: 000481591400001
- 2018
  
  Special Issue in Honor of Gordon H. Dixon PREFACE. Systems biology in reproductive medicine. 399-402.
  Full Text via DOI: 10.1080/19396368.2018.1532556 Web of Science: 000453409200001
- 2017
  
  Why are we still talking about chromosomal heteromorphisms?. Reproductive BioMedicine Online. 1-2.
  Full Text via DOI: 10.1016/j.rbmo.2017.05.006 Web of Science: 000407005000002
- 2017
  
  Introduction and evaluation of case-based learning in the first foundational course of an undergraduate medical curriculum. Journal of Biological Education. 295-304.
  Full Text via DOI: 10.1080/00219266.2016.1217909 Web of Science: 000405726500009
- 2013
  
  CLINICAL USE OF SPERM ANEUPLOIDY SCREENING: WHEN IS ENOUGH, ENOUGH?. Fertility and Sterility. S30-S30.
  Full Text via DOI: 10.1016/j.fertnstert.2013.07.1763 Web of Science: 000342554500097
- 2013
  
  TELOMERE ORGANIZATION WITHIN THE SPERM NUCLEUS: AN ESSENTIAL PREREQUISITE FOR NORMAL FERTILIZATION AND EMBRYOGENESIS?. Fertility and Sterility. S101-S101.
  Full Text via DOI: 10.1016/j.fertnstert.2013.07.1709 Web of Science: 000342554500328
- 2005
  
  Erratum: Sequence and comparative analysis of the chicken genome provide unique perspective on vertebrate evolution (Nature (2004) 432 (695-716)). Nature. 777.
  Full Text via DOI: 10.1038/nature03394
Review
- 2021
  
  Genome-wide mapping of genomic DNA damage: methods and implications. Cellular and Molecular Life Sciences. 6745-6762.
  Full Text via DOI: 10.1007/s00018-021-03923-6 Web of Science: 000691820000001
- 2021
  
  The Impact of SARS-CoV-2 on Sperm Cryostorage, Theoretical or Real Risk?. Medicina (Lithuania).
  Full Text via DOI: 10.3390/medicina57090946 Web of Science: 000700269600001
- 2021
  
  COVID-19 and human reproduction: A pandemic that packs a serious punch. Systems biology in reproductive medicine. 3-23.
  Full Text via DOI: 10.1080/19396368.2020.1855271 Web of Science: 000627140200002
- 2019
  
  Meiotic nondisjunction and sperm aneuploidy in humans. Reproduction. R15-R31.
  Full Text via DOI: 10.1530/REP-18-0318 Web of Science: 000456067700002
- 2018
  
  Does genome organization matter in spermatozoa? A refined hypothesis to awaken the silent vessel. Systems biology in reproductive medicine. 518-534.
  Full Text via DOI: 10.1080/19396368.2017.1421278 Web of Science: 000453409200009
- 2016
  
  Impact of sperm DNA chromatin in the clinic. Journal of Assisted Reproduction and Genetics. 157-166.
  Full Text via DOI: 10.1007/s10815-015-0624-x Web of Science: 000370774700003
- 2012
  
  Chromosomal disorders and male infertility. Asian Journal of Andrology. 32-39.
  Full Text via DOI: 10.1038/aja.2011.66 Web of Science: 000298886000005
- 2011
  
  Meiotic recombination errors, the origin of sperm aneuploidy and clinical recommendations. Systems biology in reproductive medicine. 93-101.
  Full Text via DOI: 10.3109/19396368.2010.504879 Web of Science: 000286936200013
- 2010
  
  Role of preimplantation genetic diagnosis (PGD) in current infertility practice. International Journal of Infertility and Fetal Medicine. 1-10.
  Full Text via DOI: 10.5005/jp-journals-10016-1001
- 2005
  
  The cytogenetics of preimplantation human development: insights provided by traditional and novel techniques. Chromosoma. 295-299.
  Full Text via DOI: 10.1007/s00412-005-0340-x Web of Science: 000232712500009
- 2003
  
  The genetic basis of infertility. Reproduction. 13-25.
  Full Text via DOI: 10.1530/rep.0.1260013 Web of Science: 000184160900002

principal investigator on

Gene positioning as a diagnostic and prognostic tool in ovarian cancer awarded by College of Medicine Foundation 2014 - 2017

co-principal investigator on

Grant
- Mass Scale Biosensor Threat Dianostic for In-Theater Defense Utilization awarded by U.S. Army 2010 - 2013

investigator on

Genomic instability, susceptibility to oxidative stress and cellular senescence awarded by Environmental Health Sciences 2017 - 2021

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Co-investigator Network