Chandler, Kevin

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Chandler, Kevin Graduate Faculty

Positions

Assistant Professor, Cellular and Molecular Medicine , Herbert Wertheim College of Medicine

kchandle@fiu.edu

biography

Kevin Chandler is a researcher in the Translational Glycobiology Institute at Florida International University (TGIF). He is a Harvard ProTG K12 Program Scholar under the mentorship of TGIF founders
Dr. Robert Sackstein, Dean of the College of Medicine, and Charles Dimitroff, Executive Associate Dean for Research.

selected scholarly works & creative activities

Article
- 2024
  
  Site-Specific Glycosylation Analysis of Murine and Human Fcγ Receptors Reveals High Heterogeneity at Conserved N-Glycosylation Site
  Full Text via DOI: 10.1021/acs.jproteome.3c00835 Web of Science: 001166757800001
- 2023
  
  Enrichment and nLC-MS/MS Analysis of Head and Neck Cancer Mucinome Glycoproteins
  Full Text via DOI: 10.1021/acs.jproteome.2c00746 Web of Science: 000959662800001
- 2023
  
  Enrichment and nLC-MS/MS Analysis of Head and Neck Cancer Mucinome Glycoproteins
  Full Text via DOI: 10.1021/acs.jproteome.2c00746 Web of Science: 000969026500001
- 2023
  
  Hypoxia Controls the Glycome Signature and Galectin-8-Ligand Axis to Promote Protumorigenic Properties of Metastatic Melanoma. JOURNAL OF INVESTIGATIVE DERMATOLOGY. 143:456-+.
  Full Text via DOI: 10.1016/j.jid.2022.07.033 Web of Science: 001191917600001
- 2023
  
  Multidimensional separation and analysis of alpha-1-acid glycoprotein N-glycopeptides using high-field asymmetric waveform ion mobility spectrometry (FAIMS) and nano-liquid chromatography tandem mass spectrometry. ANALYTICAL AND BIOANALYTICAL CHEMISTRY. 415:379-390.
  Full Text via DOI: 10.1007/s00216-022-04435-3 Web of Science: 000885412800002
- 2022
  
  Abstract 2400: Fucosyltransferase expression is associated with head and neck cancer survival. CANCER RESEARCH. 82:2400-2400.
  Full Text via DOI: 10.1158/1538-7445.am2022-2400
- 2022
  
  Identification of α1,2-fucosylated signaling and adhesion molecules in head and neck squamous cell carcinoma. GLYCOBIOLOGY. 32:441-455.
  Full Text via DOI: 10.1093/glycob/cwab131 Web of Science: 000776704100001
- 2021
  
  The cell adhesion molecule TMIGD1 binds to moesin and regulates tubulin acetylation and cell migration. JOURNAL OF BIOMEDICAL SCIENCE. 28.
  Full Text via DOI: 10.1186/s12929-021-00757-z Web of Science: 000694829400001
- 2021
  
  CD209L/L-SIGN and CD209/DC-SIGN Act as Receptors for SARS-CoV-2. ACS CENTRAL SCIENCE. 7:1156-1165.
  Full Text via DOI: 10.1021/acscentsci.0c01537 Web of Science: 000679934200011
- 2021
  
  Protein signatures of centenarians and their offspring suggest centenarians age slower than other humans. AGING CELL. 20.
  Full Text via DOI: 10.1111/acel.13290 Web of Science: 000612808600001
- 2020
  
  Osteocytes control myeloid cell proliferation and differentiation through Gs alpha-dependent and -independent mechanisms. FASEB JOURNAL. 34:10191-10211.
  Full Text via DOI: 10.1096/fj.202000366R Web of Science: 000541762000001
- 2020
  
  β-Catenin/CBP inhibition alters epidermal growth factor receptor fucosylation status in oral squamous cell carcinoma
  Full Text via DOI: 10.1039/d0mo00009d Web of Science: 000542588800001
- 2019
  
  N-Glycosylation regulates ligand-dependent activation and signaling of vascular endothelial growth factor receptor 2 (VEGFR2). JOURNAL OF BIOLOGICAL CHEMISTRY. 294:13117-13130.
  Full Text via DOI: 10.1074/jbc.RA119.008643 Web of Science: 000486416000021
- 2019
  
  Multi-isotype Glycoproteomic Characterization of Serum Antibody Heavy Chains Reveals Isotype- and Subclass-Specific N-Glycosylation Profiles
  Full Text via DOI: 10.1074/mcp.RA118.001185 Web of Science: 000466934700006
- 2018
  
  MINAR1 is a Notch2-binding protein that inhibits angiogenesis and breast cancer growth
  Full Text via DOI: 10.1093/jmcb/mjy002 Web of Science: 000439707300003
- 2017
  
  Site-Specific N-Glycosylation of Endothelial Cell Receptor Tyrosine Kinase VEGFR-2
  Full Text via DOI: 10.1021/acs.jproteome.6b00738 Web of Science: 000393539600029
- 2016
  
  Reconstituted B cell receptor signaling reveals carbohydrate-dependent mode of activation. SCIENTIFIC REPORTS. 6.
  Full Text via DOI: 10.1038/srep36298 Web of Science: 000386507200001
- 2014
  
  Site-Specific Glycan Microheterogeneity of Inter-Alpha-Trypsin Inhibitor Heavy Chain H4
  Full Text via DOI: 10.1021/pr500394z Web of Science: 000338693400017
- 2013
  
  Exploring Site-Specific N-Glycosylation Microheterogeneity of Haptoglobin Using Glycopeptide CID Tandem Mass Spectra and Glycan Database Search
  Full Text via DOI: 10.1021/pr400196s Web of Science: 000322852800010
- 2012
  
  N-glycans in liver-secreted and immunoglogulin-derived protein fractions. JOURNAL OF PROTEOMICS. 75:2216-2224.
  Full Text via DOI: 10.1016/j.jprot.2012.01.024 Web of Science: 000303136600019
- 2010
  
  Cadmium effects on transcriptional expression of rhlB/rhlC genes and congener distribution of monorhamnolipid and dirhamnolipid in Pseudomonas aeruginosa IGB83. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY. 88:953-963.
  Full Text via DOI: 10.1007/s00253-010-2808-8 Web of Science: 000282123800015
- 2008
  
  Design and microwave-assisted synthesis of novel macrocyclic peptides active at melanocortin receptors: Discovery of potent and selective hMC5R receptor antagonists. JOURNAL OF MEDICINAL CHEMISTRY. 51:2701-2707.
  Full Text via DOI: 10.1021/jm701181n Web of Science: 000255500000016
- 2007
  
  Novel selective human melanocortin-3 receptor ligands: Use of the 4-amino-1,2,4,5-tetrahydro-2-benzazepin-3-one (Aba) scaffold. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 17:2492-2498.
  Full Text via DOI: 10.1016/j.bmcl.2007.02.020 Web of Science: 000246087900020
- 2006
  
  Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. JOURNAL OF MEDICINAL CHEMISTRY. 49:1946-1952.
  Full Text via DOI: 10.1021/jm0510326 Web of Science: 000236400100014
- N-glycosylation in Spodoptera frugiperda (Lepidoptera: Noctuidae) midgut membrane-bound glycoproteins. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY. 246-24.
  Full Text via DOI: 10.1016/j.cbpb.2020.110464 Web of Science: 000549367100009
Conference
- 2022
  
  FUT1 Knockout Leads to Reduced alpha(1,2)-Fucosylated Epitope Expression and Reduced Receptor Tyrosine Kinase Signaling in Head and Neck Cancer Cells. GLYCOBIOLOGY. 972-972.
  Web of Science: 000878249700027
- 2022
  
  Fucosyltransferase expression is associated with head and neck cancer survival. CANCER RESEARCH.
  Web of Science: 000892509508172
- 2021
  
  Identification of alpha 1,2-Fucosylated glycoproteins in head and neck squamous cell carcinoma. GLYCOBIOLOGY. 1686-1686.
  Web of Science: 000754737200029
- 2021
  
  Abstract 2004: Understanding the role of α1,2-fucosylation in head and neck cancer. CANCER RESEARCH. 2004-2004.
  Full Text via DOI: 10.1158/1538-7445.am2021-2004
- 2021
  
  Understanding the role of α1,2-fucosylation in head and neck cancer.. CANCER RESEARCH.
  Web of Science: 000680263503068
- 2020
  
  Inhibition of beta-catenin/CBP signaling alters EGFR fucosylation status in head and neck squamous cell carcinoma. CANCER RESEARCH.
  Full Text via DOI: 10.1158/1538-7445.AM2020-5940 Web of Science: 000590059307067
- 2019
  
  Abstract 2633: Deciphering the role of protein glycosylation in oral cancer: insights into tumor biology and treatment. 2633-2633.
  Full Text via DOI: 10.1158/1538-7445.sabcs18-2633
- 2019
  
  Deciphering the role of protein glycosylation in oral cancer: insights into tumor biology and treatment. CANCER RESEARCH.
  Full Text via DOI: 10.1158/1538-7445.AM2019-2633 Web of Science: 000488279401085
- 2019
  
  Drug candidate may slow metastasis in oral cancer by affecting N-linked glycosylation on the epidermal growth factor receptor (EGFR). ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
  Web of Science: 000478860501649
- 2019
  
  On-line nanoLC-ion mobility-electron capture dissociation-QTOF MS/MS Analysis of biopolymers and mixtures. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
  Web of Science: 000478860500434
- 2018
  
  Osteocyte regulates osteoclasts formation through Neuropilin1. 382-382.
  Web of Science: 000450475401750
- 2018
  
  Analysis of epidermal growth factor receptor glycosylation by advanced mass spectrometric methods. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
  Web of Science: 000447600001694
- 2018
  
  Exploring receptor tyrosine kinase N-glycosylation and signaling via nanoLC-MS/MS using higher-energy collisional dissociation and stepped collision energy. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
  Web of Science: 000447600001219
- 2018
  
  Glycosylation impacts antibody Fc receptor function and is tuned by the immune system. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
  Web of Science: 000447600001745
- 2018
  
  Abstract 2516: Inhibition of Β-catenin/CBP signaling in oral cancer alters EGFR N-glycosylation and abundance. CANCER RESEARCH. 2516-2516.
  Full Text via DOI: 10.1158/1538-7445.am2018-2516
- 2018
  
  N-glycosylation modulates endothelial cell receptor tyrosine kinase VEGFR-2 ligand-dependent activation and signaling. CANCER RESEARCH.
  Full Text via DOI: 10.1158/1538-7445.AM2018-2047 Web of Science: 000468818904436
- 2017
  
  Glycosylation impacts antibody Fc receptor function and is tuned by the immune system. GLYCOBIOLOGY. 1227-1227.
  Web of Science: 000423267000141
- 2017
  
  Vascular endothelial growth factor receptor-2 (VEGFR-2) N-glycosylation modulates angiogenic signaling. CANCER RESEARCH.
  Full Text via DOI: 10.1158/1538-7445.AM2017-1808 Web of Science: 000442496704192
- 2017
  
  Glycoproteins in the Midgut Microvilar Membrane of Spodoptera frugiperda (Lepidoptera: Noctuidae). FASEB JOURNAL.
  Web of Science: 000405461402371
- 2016
  
  Analysis of Vascular Endothelial Growth Factor Receptor 2 (VEGFR-2) Glycosylation and its Role in Angiogenesis. FASEB JOURNAL.
  Web of Science: 000406444002510
- 2012
  
  Semi-Automated Identification of N-Glycopeptides by Hydrophilic Interaction Chromatography, nano-Reverse-Phase LC-MS/MS, and Glycan Database Search. 1728-1740.
  Full Text via DOI: 10.1021/pr201183w Web of Science: 000300916200027
- 2010
  
  N-glycosylation in cultured cells and hepatocellular carcinoma. CANCER RESEARCH.
  Full Text via DOI: 10.1158/1538-7445.AM10-5569 Web of Science: 000209823800249
- 2007
  
  Design, synthesis, and evaluation of novel peptidomimetics. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 591-591.
  Web of Science: 000207722806433
- 2007
  
  New peptidomimetics for the study of GP CRs. BIOPOLYMERS. 630-630.
  Web of Science: 000247425900464
- 2006
  
  Novel MTH/AGRP hybrid analogs that lead to selective Ligands for the human melanocortin receptors. 399-+.
  Full Text via DOI: 10.1007/978-0-387-26575-9_165 Web of Science: 000240543800165
- 2006
  
  Novel and highly selective antagonist scaffold for human melanocortin 3 receptor: Computer-aided design and biological evaluation. 651-+.
  Full Text via DOI: 10.1007/978-0-387-26575-9_288 Web of Science: 000240543800288
- 2005
  
  Novel and highly selective antagonist scaffold for human melanocortin 3 receptor: Computer-aided design and biological evaluation. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. U110-U110.
  Web of Science: 000235066600028
- 2005
  
  Design, synthesis of novel MTII/AGRP hybrid analogues and their biological activities. BIOPOLYMERS. 556-556.
  Web of Science: 000229901200335
- 2005
  
  Novel and highly selective antagonist scaffold for human melanocortin 3 receptor: Computer-aided design and biological evaluation. BIOPOLYMERS. 588-588.
  Web of Science: 000229901200485
Other Scholarly Work
- 2023
  
  Enrichment and Analysis of Head and Neck Cancer Mucin-Domain Glycoproteins Reveals the Presence of Tumor-Derived Immunoglobulin A. S370-S370.
  Full Text via DOI: 10.1016/j.jbc.2023.103705 Web of Science: 001040892100631
- 2022
  
  Association Between Glycosyltransferase Expression and Survival in Head and Neck Cancer. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS. E30-E30.
  Web of Science: 000769937700059
Preprint
- 2021
  
  CD209L/L-SIGN and CD209/DC-SIGN act as receptors for SARS-CoV-2.
  Full Text via DOI: 10.1101/2020.06.22.165803
- The Cell Adhesion Molecule TMIGD1 Binds to Moesin and Regulates Tubulin Acetylation and Cell Migration
  Full Text via DOI: 10.1101/2021.08.08.455580
Review
- 2019
  
  Glycosylation in the Tumor Microenvironment: Implications for Tumor Angiogenesis and Metastasis
  Full Text via DOI: 10.3390/cells8060544 Web of Science: 000475309200032
- 2016
  
  Glycomics and glycoproteomics of membrane proteins and cell-surface receptors: Present trends and future opportunities. ELECTROPHORESIS. 1407-1419.
  Full Text via DOI: 10.1002/elps.201500552 Web of Science: 000379135200004
- 2013
  
  Glycoprotein Disease Markers and Single Protein-omics. 836-845.
  Full Text via DOI: 10.1074/mcp.R112.026930 Web of Science: 000317341500002
- 2006
  
  Design, synthesis, and biological evaluation of a new class of small molecule peptide mimetics targeting the melanocortin receptors. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 5462-5467.
  Full Text via DOI: 10.1016/j.bmcl.2006.07.015 Web of Science: 000241344400043

principal investigator on

Tumor-Derived Immunoglobulin Driven Resistance to anti-PD1/PDL1 Axis Therapy awarded by American Head and Neck Society 2023 - 2024
Forging Translational Glycobiologists: Intermeshing Glycoscience Training and Clinical Education: Chandler KB awarded by National Heart, Lung, & Blood Institute 2020 - 2024
Head and Neck Cancer Mucinomics awarded by American Society of Clinical Oncology 2022 - 2023

investigator on

Forging Translational Glycobiologists: Intermeshing Glycoscience Training and Clinical Education: Chandler KB awarded by National Heart, Lung, & Blood Institute 2020 - 2024

full name

Kevin Chandler

ORCID iD

https://orcid.org/0000-0001-5514-9652 (confirmed)

visualizations

Co-author Network

Co-investigator Network