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Agoulnik, Irina
Positions
Professor
,
Human and Molecular Genetics
,
Herbert Wertheim College of Medicine
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Scholarly & Creative Works
Research
Identifiers
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Scholarly & Creative Works
Patents issued
Modulators of the Relaxin Receptor 1
Patent
Modulators of the Relaxin Receptor 1
Patent
Treatments of Prostate Cancer
Patent
selected scholarly works & creative activities
Article
2023
Regulation of EZH2 Expression by INPP4B in Normal Prostate and Primary Prostate Cancer
Full Text via DOI:
10.3390/cancers15225418
Web of Science:
001107898400001
2022
Discovery of small molecule agonists of the Relaxin Family Peptide Receptor 2
Full Text via DOI:
10.1038/s42003-022-04143-9
Web of Science:
000879050900003
2022
Abstract 815: Regulation of p53 by INPP4B and high fat diet in mouse prostate
.
CANCER RESEARCH
. 82:815-815.
Full Text via DOI:
10.1158/1538-7445.am2022-815
2021
INPP4B protects from metabolic syndrome and associated disorders
Full Text via DOI:
10.1038/s42003-021-01940-6
Web of Science:
000635193900004
2020
Deletion of inositol polyphosphate 4-phosphatase type-II B affects spermatogenesis in mice
.
PLOS ONE
. 15.
Full Text via DOI:
10.1371/journal.pone.0233163
Web of Science:
000537496000052
2020
Androgen Receptor and Poly(ADP-ribose) Glycohydrolase Inhibition Increases Efficiency of Androgen Ablation in Prostate Cancer Cells
.
SCIENTIFIC REPORTS
. 10.
Full Text via DOI:
10.1038/s41598-020-60849-y
Web of Science:
000562886900005
2020
Inhibition of base excision repair by natamycin suppresses prostate cancer cell proliferation
.
BIOCHIMIE
. 168:241-250.
Full Text via DOI:
10.1016/j.biochi.2019.11.008
Web of Science:
000503444300022
2020
Oxidative DNA Damage Modulates DNA Methylation Pattern in Human Breast Cancer 1 (BRCA1) Gene via the Crosstalk between DNA Polymerase β and a
de novo
DNA Methyltransferase
Full Text via DOI:
10.3390/cells9010225
Web of Science:
000515398200225
2019
Therapeutic effects of a small molecule agonist of the relaxin receptor ML290 in liver fibrosis
.
FASEB JOURNAL
. 33:12435-12446.
Full Text via DOI:
10.1096/fj.201901046R
Web of Science:
000507461600065
2019
Small molecule allosteric agonist of relaxin receptor ML290 demonstrates antifibrotic properties in liver fibrosis
Full Text via DOI:
10.1530/endoabs.63.gp223
2019
SAT-035 Small Molecule Allosteric Agonist of Relaxin Receptor Ml290 Demonstrates Antifibrotic Properties in Liver Fibrosis
Full Text via DOI:
10.1210/js.2019-sat-035
2019
SAT-326 INPP4B Suppresses Prostate Inflammation And Protects Mice Fed With High-fat Diet From The Development Of Prostate Intraepithelial Neoplasia
Full Text via DOI:
10.1210/js.2019-sat-326
2019
Inositol polyphosphate 4-phosphatase type II regulation of androgen receptor activity
.
ONCOGENE
. 38:1121-1135.
Full Text via DOI:
10.1038/s41388-018-0498-3
Web of Science:
000458624900014
2018
Optimization of the first small-molecule relaxin/insulin-like family peptide receptor (RXFP1) agonists: Activation results in an antifibrotic gene expression profile
.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
. 156:79-92.
Full Text via DOI:
10.1016/j.ejmech.2018.06.008
Web of Science:
000443663200007
2018
Techniques for Evaluation of AR Transcriptional Output and Recruitment to DNA
Full Text via DOI:
10.1007/978-1-4939-7845-8_13
Web of Science:
000443077100014
2017
Human Relaxin Receptor Is Fully Functional in Humanized Mice and Is Activated by Small Molecule Agonist ML290
Full Text via DOI:
10.1210/js.2017-00112
Web of Science:
000425346100016
2017
Multiferroic coreshell magnetoelectric nanoparticles as NMR sensitive nanoprobes for cancer cell detection
.
SCIENTIFIC REPORTS
. 7.
Full Text via DOI:
10.1038/s41598-017-01647-x
Web of Science:
000425893300001
2017
Regulation of steroid receptor signalling by tumor suppressor INPP4B
Full Text via DOI:
10.1530/endoabs.49.oc7.5
2017
Therapeutic potentials of small molecular weight allosteric agonist of relaxin receptor
Full Text via DOI:
10.1530/endoabs.49.ep754
2016
Nuclear Receptor Corepressor 1 Expression and Output Declines with Prostate Cancer Progression
.
CLINICAL CANCER RESEARCH
. 22:3937-3949.
Full Text via DOI:
10.1158/1078-0432.CCR-15-1983
Web of Science:
000382265600026
2016
INPP4B is an oncogenic regulator in human colon cancer
.
ONCOGENE
. 35:3049-3061.
Full Text via DOI:
10.1038/onc.2015.361
Web of Science:
000377474500010
2016
Structural Insights into the Activation of Human Relaxin Family Peptide Receptor 1 by Small-Molecule Agonists
.
BIOCHEMISTRY
. 55:1772-1783.
Full Text via DOI:
10.1021/acs.biochem.5b01195
Web of Science:
000373247600011
2015
Activation of relaxin family receptor 1 from different mammalian species by relaxin peptide and small-molecule agonist ML290
.
FRONTIERS IN ENDOCRINOLOGY
. 6.
Full Text via DOI:
10.3389/fendo.2015.00128
Web of Science:
000378398700001
2015
In Silico
Adoption of an Orphan Nuclear Receptor NR4A1
.
PLOS ONE
. 10.
Full Text via DOI:
10.1371/journal.pone.0135246
Web of Science:
000359492800044
2015
Coordinated Expression of Phosphoinositide Metabolic Genes during Development and Aging of Human Dorsolateral Prefrontal Cortex
.
PLOS ONE
. 10.
Full Text via DOI:
10.1371/journal.pone.0132675
Web of Science:
000358193100065
2014
INPP4B suppresses prostate cancer cell invasion
.
CELL COMMUNICATION AND SIGNALING
. 12.
Full Text via DOI:
10.1186/s12964-014-0061-y
Web of Science:
000346520800001
2014
Base Excision Repair of Chemotherapeutically-Induced Alkylated DNA Damage Predominantly Causes Contractions of Expanded GAA Repeats Associated with Friedreich's Ataxia
.
PLOS ONE
. 9.
Full Text via DOI:
10.1371/journal.pone.0093464
Web of Science:
000334101100085
2013
Determinants of the tumor suppressor INPP4B protein and lipid phosphatase activities
.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
. 440:277-282.
Full Text via DOI:
10.1016/j.bbrc.2013.09.077
Web of Science:
000326137700014
2013
Identification of Small-Molecule Agonists of Human Relaxin Family Receptor 1 (RXFP1) by Using a Homogenous Cell-Based cAMP Assay
.
JOURNAL OF BIOMOLECULAR SCREENING
. 18:670-677.
Full Text via DOI:
10.1177/1087057112469406
Web of Science:
000320888100004
2013
Identification and optimization of small-molecule agonists of the human relaxin hormone receptor RXFP1
.
NATURE COMMUNICATIONS
. 4.
Full Text via DOI:
10.1038/ncomms2953
Web of Science:
000323624100021
2013
Reduced Androgen Receptor Expression Accelerates the Onset of ERBB2 Induced Breast Tumors in Female Mice
.
PLOS ONE
. 8.
Full Text via DOI:
10.1371/journal.pone.0060455
Web of Science:
000317898000033
2013
Targeted disruption of the p160 coactivator interface of androgen receptor (AR) selectively inhibits AR activity in both androgen-dependent and castration-resistant AR-expressing prostate cancer cells
Full Text via DOI:
10.1016/j.biocel.2012.12.012
Web of Science:
000317371300001
2012
Androgen receptor footprint on the way to prostate cancer progression
.
WORLD JOURNAL OF UROLOGY
. 30:279-285.
Full Text via DOI:
10.1007/s00345-011-0743-7
Web of Science:
000304558800002
2011
INPP4B: the New Kid on the PI3K Block
Web of Science:
000293509600011
2011
Decreased Expression and Androgen Regulation of the Tumor Suppressor Gene INPP4B in Prostate Cancer
.
CANCER RESEARCH
. 71:572-582.
Full Text via DOI:
10.1158/0008-5472.CAN-10-2314
Web of Science:
000286193900028
2010
Suppression of relaxin receptor RXFP1 decreases prostate cancer growth and metastasis
.
ENDOCRINE-RELATED CANCER
. 17:1021-1033.
Full Text via DOI:
10.1677/ERC-10-0073
Web of Science:
000284490000021
2009
Coactivator selective regulation of androgen receptor activity
.
STEROIDS
. 74:669-674.
Full Text via DOI:
10.1016/j.steroids.2009.02.007
Web of Science:
000267236100007
2009
Relaxin Signaling in Uterine Fibroids
.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
. 1160:374-378.
Full Text via DOI:
10.1111/j.1749-6632.2008.03803.x
Web of Science:
000265652100073
2009
Relaxin/RXFP1 Signaling in Prostate Cancer Progression
.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
. 1160:379-380.
Full Text via DOI:
10.1111/j.1749-6632.2008.03793.x
Web of Science:
000265652100074
2008
Target Gene-Specific Regulation of Androgen Receptor Activity by p42/p44 Mitogen-Activated Protein Kinase
.
MOLECULAR ENDOCRINOLOGY
. 22:2420-2432.
Full Text via DOI:
10.1210/me.2007-0481
Web of Science:
000260429400005
2008
Androgen receptor coactivators and prostate cancer
Web of Science:
000253701800023
2007
Developmental expression and gene regulation of insulin-like 3 receptor RXFP2 in mouse male reproductive organs
.
BIOLOGY OF REPRODUCTION
. 77:671-680.
Full Text via DOI:
10.1095/biolreprod.107.060442
Web of Science:
000249766700010
2007
Relaxin promotes prostate cancer progression
.
CLINICAL CANCER RESEARCH
. 13:1695-1702.
Full Text via DOI:
10.1158/1078-0432.CCR-06-2492
Web of Science:
000245031800013
2006
Androgens modulate expression of transcription intermediary factor 2, an androgen receptor coactivator whose expression level correlates with early biochemical recurrence in prostate cancer
.
CANCER RESEARCH
. 66:10594-10602.
Full Text via DOI:
10.1158/0008-5472.CAN-06-1023
Web of Science:
000241781600050
2006
Androgen receptor action in hormone-dependent and recurrent prostate cancer
.
JOURNAL OF CELLULAR BIOCHEMISTRY
. 99:362-372.
Full Text via DOI:
10.1002/jcb.20811
Web of Science:
000240758600004
2006
Quantifying effects of ligands on androgen receptor nuclear translocation, intranuclear dynamics, and solubility
.
JOURNAL OF CELLULAR BIOCHEMISTRY
. 98:770-788.
Full Text via DOI:
10.1002/jcb.20593
Web of Science:
000238521400008
2006
The role of relaxin in endometrial cancer
.
CANCER BIOLOGY & THERAPY
. 5:71-77.
Full Text via DOI:
10.4161/cbt.5.1.2289
Web of Science:
000236044500020
2005
Pim-2 upregulation: Biological implications associated with disease progression and perinueral invasion in prostate cancer
.
PROSTATE
. 65:276-286.
Full Text via DOI:
10.1002/pros.20294
Web of Science:
000232603100010
2005
Androgen receptor signaling and vitamin D receptor action in prostate cancer cells
.
PROSTATE
. 64:362-372.
Full Text via DOI:
10.1002/pros.20251
Web of Science:
000231369100006
2005
Role of SRC-1 in the promotion of prostate cancer cell growth and tumor progression
.
CANCER RESEARCH
. 65:7959-7967.
Full Text via DOI:
10.1158/0008-5472.CAN-04-3541
Web of Science:
000231659500057
2004
A germline variation in the progesterone receptor gene increases transcriptional activity and may modify ovarian cancer risk
.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
. 89:6340-6347.
Full Text via DOI:
10.1210/jc.2004-0114
Web of Science:
000225495400071
2003
Repressors of androgen and progesterone receptor action
.
JOURNAL OF BIOLOGICAL CHEMISTRY
. 278:31136-31148.
Full Text via DOI:
10.1074/jbc.M305153200
Web of Science:
000184658800091
2003
Biodistribution and pharmacokinetics of aerosol and intravenously administered DNA-polyethyleneimine complexes: Optimization of pulmonary delivery and retention
Full Text via DOI:
10.1016/S1525-0016(03)00177-1
Web of Science:
000184767300009
2002
A novel androgen receptor mutant, A748T, exhibits hormone concentration-dependent defects in nuclear accumulation and activity despite normal hormone-binding affinity
.
MOLECULAR ENDOCRINOLOGY
. 16:2692-2705.
Full Text via DOI:
10.1210/me.2001-0281
Web of Science:
000179689700002
2000
A transgenic insertion upstream of
Sox9
is associated with dominant XX sex reversal in the mouse
Full Text via DOI:
10.1038/82652
Web of Science:
000165671700027
1998
Adenovirus mediated thymidine kinase gene therapy may enhance sensitivity of ovarian cancer cells to chemotherapeutic agents
.
ANTICANCER RESEARCH
. 18:3421-3426.
Web of Science:
000077376000042
1998
Cloning, expression analysis and chromosomal localization of the human nuclear receptor gene GCNF
.
FEBS LETTERS
. 424:73-78.
Full Text via DOI:
10.1016/S0014-5793(98)00142-2
Web of Science:
000072524600016
1998
Improvement of gene therapy for ovarian cancer by using acyclovir instead of ganciclovir in adenovirus mediated thymidine kinase gene therapy
.
ANTICANCER RESEARCH
. 18:713-718.
Web of Science:
000073827300004
1998
The efficacy of adenovirus-mediated gene therapy of ovarian cancer is enhanced by using the cytomegalovirus promoter
.
ANTICANCER RESEARCH
. 18:719-725.
Web of Science:
000073827300005
1998
A Genetic Mutation in the Progesterone Receptor (PROGINS) leads to an increased risk of non-familial breast and ovarian cancer causing inadequate control of estrogen receptor driven proliferation
.
REPRODUCTIVE SCIENCES
. 5:40a-40a.
Full Text via DOI:
10.1016/s1071-5576(97)86082-0
1998
Toxicity reduction of adenovirus mediated thymidine kinase gene therapy for ovarian cancer and subsequent combination with topoisomerase inhibitors: Design of a clinical phase I study
.
REPRODUCTIVE SCIENCES
. 5:47a-47a.
Full Text via DOI:
10.1016/s1071-5576(97)86111-4
1997
Human epithelial ovarian cancer xenotransplants into nude mice can be cured by adenovirus-mediated thymidine kinase gene therapy
.
ANTICANCER RESEARCH
. 17:811-813.
Web of Science:
A1997WU02200003
1996
In vivo gene therapy of ovarian cancer by adenovirus-mediated thymidine kinase gene transduction and ganciclovir administration
.
GYNECOLOGIC ONCOLOGY
. 61:175-179.
Full Text via DOI:
10.1006/gyno.1996.0121
Web of Science:
A1996UK90100003
Telomere length in human white blood cells remains constant with age and is shorter in breast cancer patients
.
ANTICANCER RESEARCH
. 18:1345-1349.
Web of Science:
000074737300001
Book Chapter
2013
Roles of androgen receptor coregulators and cell signaling in the regulation of androgen-responsive genes
. 1-11.
Full Text via DOI:
10.1007/978-1-4614-6182-1_1
2009
Coregulators and the Regulation of Androgen Receptor Action in Prostate Cancer
. 315-340.
Full Text via DOI:
10.1007/978-0-387-69179-4_14
Web of Science:
000268335300015
2008
Androgen Receptor Coactivators in Prostate Cancer
. 281-300.
Full Text via DOI:
10.1142/9789812819178_0007
2008
Androgen receptor coactivators in prostate cancer
. 294-313.
Full Text via DOI:
10.1142/9789812819178_0007
2003
Steroid Receptor Crosstalk with Cellular Signaling Pathways
. 420-427.
Full Text via DOI:
10.1016/b0-12-341103-3/00277-1
Conference
2022
Regulation of p53 by INPP4B and high fat diet in mouse prostate
.
CANCER RESEARCH
.
Web of Science:
000892509506116
2021
DNA Base Excision Repair Capacity in Tissues of Friedreich's Ataxia Transgenic Mice.
.
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
. 55-55.
Web of Science:
000687648100070
2021
Mapping of DNA Damage in Prostate Cancer-related Genes in Vivo.
.
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
. 86-86.
Web of Science:
000687648100138
2021
Abstract 2497: Inositol Polyphosphate 4-Phosphatase Type-II B protects mice from benign prostatic hyperplasia
.
CANCER RESEARCH
. 2497-2497.
Full Text via DOI:
10.1158/1538-7445.am2021-2497
2021
Inositol Polyphosphate 4-Phosphatase Type-II B protects mice from benign prostatic hyperplasia.
.
CANCER RESEARCH
.
Web of Science:
000680263507400
2017
Structural modeling and identification of small molecule agonists of human relaxin family peptide receptor 1
.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
.
Web of Science:
000430568505930
2013
Structural modeling of the relaxin peptide receptor and its small molecule agonists
.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
.
Web of Science:
000323851304270
2012
Sympathetic Neurotransmission Increases Local TGF-beta-2 in the Eye and Supports Ocular Inflammation
.
NEUROLOGY
.
Web of Science:
000303204804118
2010
GEMS (Gene Expression MetaSignatures), a Web Resource for Querying Meta-Analysis of Expression Microarray Datasets: Dihydrotestosterone in LNCaP Cells.
.
ENDOCRINE REVIEWS
.
Web of Science:
000281989403066
2009
Suppression of Relaxin receptor RXFP1 in Prostate Cancer Cells Decreases Tumor Growth and Metastasis in vivo
.
CANCER RESEARCH
.
Web of Science:
000209702705445
2000
Male sexual development in the absence of Sry.
.
AMERICAN JOURNAL OF HUMAN GENETICS
. 1724-1724.
Web of Science:
000088373700034
1999
Comparison of long-term survival of cytomegalovirus promoter versus Rous Sarcoma virus promoter-driven thymidine kinase gene therapy in nude mice bearing human ovarian cancer
. 93-97.
Full Text via DOI:
10.1089/hyb.1999.18.93
Web of Science:
000079255800015
Other Scholarly Work
2022
Editorial: Sphingolipid metabolism and cancer
Full Text via DOI:
10.3389/fonc.2022.1049494
Web of Science:
000886491500001
2022
RXFP2 Small Molecule Agonists: Potential Therapeutics for Osteoporosis
.
FASEB JOURNAL
.
Full Text via DOI:
10.1096/fasebj.2022.36.S1.R2398
Web of Science:
000878430602245
2017
Multiferroic coreshell magnetoelectric nanoparticles as NMR sensitive nanoprobes for cancer cell detection (vol 7, 1610, 2017)
.
SCIENTIFIC REPORTS
.
Full Text via DOI:
10.1038/s41598-017-12311-9
Web of Science:
000413816000067
2015
Long-Lasting Consequences of Testosterone Exposure
.
ENDOCRINOLOGY
. 3488-3489.
Full Text via DOI:
10.1210/en.2015-1719
Web of Science:
000362235300014
1996
Gene sequence and evolutionary conservation of human SMCY (vol 14, pg 128, 1996)
. 252-252.
Web of Science:
A1996VQ14600015
Review
2022
Expression patterns and the roles of phosphatidylinositol phosphatases in testis
†
.
BIOLOGY OF REPRODUCTION
. 902-915.
Full Text via DOI:
10.1093/biolre/ioac132
Web of Science:
000838505900001
2017
Synthetic non-peptide low molecular weight agonists of the relaxin receptor 1
.
BRITISH JOURNAL OF PHARMACOLOGY
. 977-989.
Full Text via DOI:
10.1111/bph.13656
Web of Science:
000400597900006
Research
principal investigator on
Targeting breast cancer microenvironment with small molecule agonist of relaxin receptor
awarded by
National Cancer Institute
2023 - 2025
Baptist Cancer Research Lab
awarded by
Baptist Health South Florida
2015 - 2023
Regulation of metastases by tumor suppressor INPP4B
awarded by
National Cancer Institute
2014 - 2018
DORBRDG -Role of NCoR in Angiandrogen Resistance...
awarded by
FIU Office of Research and Economic Deve
2013 - 2014
Structural Studies of tumor suppressor INPP4B
awarded by
FIU Office of Research and Economic Deve
2011 - 2012
Androgen Regulation of Novel Tumor Suppressor in Male and Female Breast Cancer
awarded by
U.S. Department of Defense
2010 - 2011
Role of NCoR in Antiandrogen Resistance in Prostate Cancer
awarded by
National Cancer Institute
2010 - 2011
co-principal investigator on
Grant
Novel Chemotherapeutic Treatment for Prostate Cancer
awarded by
Community Foundation of Broward
2019 - 2020
Investigation of a Novel Treatment for Advanced Prostate Cancer
awarded by
Community Foundation of Broward
2016 - 2018
subproject principal investigator on
Investigation of a Novel Treatment for Advanced Prostate Cancer
awarded by
Community Foundation of Broward
2016 - 2018
Investigation of a Novel Treatment for Advanced Prostate Cancer
awarded by
Community Foundation of Broward
2015
investigator on
Engineering a long-acting relaxin agonist to treat liver fibrosis
awarded by
National Institutes of Health
2021 - 2023
Relaxin receptor agonists for treatment of liver fibrosis
awarded by
Diabetes & Digestive & Kidney Diseases
2017 - 2023
Small molecule agonists of insulin-like3 receptor for osteoporosis treatment
awarded by
Arthritis & Musculoskeletal & Skin Disea
2016 - 2020
Small molecule antagonists of relaxin receptor
awarded by
National Cancer Institute
2013 - 2017
Investigation of a Novel Treatment for Advanced Prostate Cancer
awarded by
Community Foundation of Broward
2015
Small molecule agonists of relaxin receptor
awarded by
Bristol-Myers Squibb
2014 - 2015
Identifiers
ORCID iD
https://orcid.org/0000-0003-4889-0324
(confirmed)
visualizations
Co-author Network
Co-investigator Network
Map of Science
publication subject areas
Biochemistry & Molecular Biology
Biophysics
Cell Biology
Chemistry
Endocrinology & Metabolism
Genetics & Heredity
Neurosciences & Neurology
Oncology
Pharmacology & Pharmacy
Science & Technology - Other Topics
Urology & Nephrology
Citation index-derived subject areas the researcher has published in