Hydra as a tractable, long-lived model system for senescence Article

Bellantuono, AJ, Bridge, D, Martínez, DE. (2015). Hydra as a tractable, long-lived model system for senescence . 59 39-44. 10.1080/07924259.2014.938196

cited authors

  • Bellantuono, AJ; Bridge, D; Martínez, DE

authors

abstract

  • Hydra represents a unique model system for the study of senescence, with the opportunity for the comparison of non-aging and induced senescence. Hydra maintains three stem cell lineages, used for continuous tissue morphogenesis and replacement. Recent work has elucidated the roles of the insulin/IGF-1 signaling target FoxO, of Myc proteins, and of PIWI proteins in Hydra stem cells. Under laboratory culture conditions, Hydra vulgaris show no signs of aging even under long-term study. In contrast, Hydra oligactis can be experimentally induced to undergo reproduction-associated senescence. This provides a powerful comparative system for future studies.

publication date

  • January 30, 2015

Digital Object Identifier (DOI)

start page

  • 39

end page

  • 44

volume

  • 59