6-Benzothiazolyl Ureas, Thioureas and Guanidines are Potent Inhibitors of ABAD/17 beta-HSD10 and Potential Drugs for Alzheimer's Disease Treatment: Design, Synthesis and in vitro Evaluation Article

Benek, Ondrej, Hroch, Lukas, Aitken, Laura et al. (2017). 6-Benzothiazolyl Ureas, Thioureas and Guanidines are Potent Inhibitors of ABAD/17 beta-HSD10 and Potential Drugs for Alzheimer's Disease Treatment: Design, Synthesis and in vitro Evaluation . 13(4), 345-358. 10.2174/1573406413666170109142725

Open Access International Collaboration

cited authors

  • Benek, Ondrej; Hroch, Lukas; Aitken, Laura; Dolezal, Rafael; Hughes, Rebecca; Guest, Patrick; Benkova, Marketa; Soukup, Ondrej; Musil, Karel; Kuca, Kamil; Smith, Terry K; Gunn-Moore, Frank; Musilek, Kamil

sustainable development goals

authors

publication date

  • January 1, 2017

webpage

keywords

  • 17 beta-hydroxysteroid dehydrogenase type 10 (17 beta-HSD10)
  • 17-BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE 10
  • A-BETA
  • ACCUMULATION
  • ALIGNMENT
  • Chemistry, Medicinal
  • HYPOTHESIS
  • IDENTIFICATION
  • Life Sciences & Biomedicine
  • MITOCHONDRIAL
  • MODULATORS
  • Pharmacology & Pharmacy
  • QSAR
  • QSAR ANALYSIS
  • REDUCTION
  • Science & Technology
  • alzheimer's disease
  • amyloid-beta binding alcohol dehydrogenase (ABAD)
  • chemical synthesis
  • enzyme inhibition
  • frentizole
  • pharmacophore modelling

Digital Object Identifier (DOI)

publisher

  • BENTHAM SCIENCE PUBL LTD

start page

  • 345

end page

  • 358

volume

  • 13

issue

  • 4