A polymeric electroporation microneedle array for enhanced intracellular delivery Conference

Choi, SO, Kim, YC, Hutcheson, J et al. (2008). A polymeric electroporation microneedle array for enhanced intracellular delivery . 1263-1265.

cited authors

  • Choi, SO; Kim, YC; Hutcheson, J; Lee, JW; Prausnitz, MR; Allen, MG

authors

abstract

  • We present a polymer-based microneedle array designed to deliver drugs and genes into cells by electroporation. Electrical functionality required for electroporation was implemented to the microneedle array by combining double-layer inclined UV lithography and metal transfer micromolding. The fabricated microneedle array was successfully inserted into pig cadaver skin, verifying mechanical functionality of the device. In vitro study was performed to examine the capability of delivering molecules into cells using the microneedle array. Calcein was chosen as a model molecule, and it was successfully delivered into DU145 human prostate cancer cells after electroporation. © 2008 CBMS.

publication date

  • January 1, 2008

start page

  • 1263

end page

  • 1265