ST6GAL1 Glycoengineering Rewires Cytokine Signaling and Preserves Metabolic Fitness in CAR-T Cells Under Galectin-3-Mediated Immunosuppression Article

Lau, Lee Seng, Suarez, Maria, Berdalinova, Aizada et al. (2026). ST6GAL1 Glycoengineering Rewires Cytokine Signaling and Preserves Metabolic Fitness in CAR-T Cells Under Galectin-3-Mediated Immunosuppression . International Journal of Molecular Sciences, 27(14), 10.3390/ijms27146393

cited authors

  • Lau, Lee Seng; Suarez, Maria; Berdalinova, Aizada; Fan, Rebecca Z; Shil, Rajib Kumar; Souchak, Joseph; Tieu, Kim; Posey Jr, Avery D; Dimitroff, Charles J

authors

publication date

  • July 18, 2026

published in

keywords

  • ACTIVATION
  • Biochemistry & Molecular Biology
  • CAR-T cell
  • Chemistry
  • Chemistry, Multidisciplinary
  • EXPRESSION
  • Gal-3
  • IMMUNITY
  • JAK/STAT signaling
  • Life Sciences & Biomedicine
  • Physical Sciences
  • SOCS1
  • ST6GAL1
  • Science & Technology
  • glycoengineering
  • metabolism
  • tumor microenvironment

Digital Object Identifier (DOI)

publisher

  • MDPI

volume

  • 27

issue

  • 14