FIU Discovery

ST6GAL1 Glycoengineering Rewires Cytokine Signaling and Preserves Metabolic Fitness in CAR-T Cells Under Galectin-3-Mediated Immunosuppression.  International Journal of Molecular Sciences.  27.

DRP1 induces neuroinflammation via transcriptional regulation of NF-ĸB..  NATURE COMMUNICATIONS.  17.

DRP1 induces neuroinflammation via transcriptional regulation of NF-ĸB..  bioRxiv. 

Imbalanced mitochondrial dynamics in human PD and α-synuclein mouse brains.  Neurobiology of Disease.  212.

Therapeutic Efficacy of Small Extracellular Vesicles Loaded with ROCK Inhibitor in Parkinson's Disease.  Pharmaceutics.  17.

Toxin-Induced Animal Models of Parkinson's Disease.  Cold Spring Harbor Perspectives in Medicine.  15.

A partial Drp1 knockout improves autophagy flux independent of mitochondrial function.  Molecular Neurodegeneration.  19.

Mitochondrial hyperfusion induces metabolic remodeling in lung endothelial cells by modifying the activities of electron transport chain complexes I and III.  FREE RADICAL BIOLOGY AND MEDICINE.  210:183-194.

Metabolic reprogramming, oxidative stress, and pulmonary hypertension.  REDOX BIOLOGY.  64.

Nitration-mediated activation of the small GTPase RhoA stimulates cellular glycolysis through enhanced mitochondrial fission.  JOURNAL OF BIOLOGICAL CHEMISTRY.  299.

Sex and APOE Genotype Alter the Basal and Induced Inflammatory States of Primary Astrocytes from Humanized Targeted Replacement Mice.  ASN Neuro.  15.

Loss of SOX18/CLAUDIN5 disrupts the pulmonary endothelial barrier in ventilator-induced lung injury.  Frontiers in Physiology.  13.

Abstract 14973: Upregulated Sphingosine-1-Phosphate Receptor 3 Disrupts Endothelial Cell Barrier and Mitochondrial Network Dynamics.  CIRCULATION.  146:a14973-a14973.

Sex and APOE Genotype Alter the Basal and Induced Inflammatory States of Primary Microglia from APOE Targeted Replacement Mice.  International Journal of Molecular Sciences.  23.

Relationship of Blood and Urinary Manganese Levels with Cognitive Function in Elderly Individuals in the United States by Race/Ethnicity, NHANES 2011-2014.  Toxics.  10.

NAMPT-associated gene signature in the prediction of severe sepsis.  AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH.  14:7090-+.

Microglial exosomes facilitate α-synuclein transmission in Parkinson's disease.  BRAIN.  143:1476-1497.

Exosome release and neuropathology induced by α-synuclein: new insights into protective mechanisms of Drp1 inhibition.  ACTA NEUROPATHOLOGICA COMMUNICATIONS.  7.

PINK1 signalling rescues amyloid pathology and mitochondrial dysfunction in Alzheimer's disease.  BRAIN.  140:3233-3251.

Mitochondrial division inhibitor-1 is neuroprotective in the A53T-α-synuclein rat model of Parkinson's disease.  SCIENTIFIC REPORTS.  7.

Blocking mitochondrial fission is protective in dopaminergic neuronal cells with inducible α-synuclein expression.  PARKINSONISM & RELATED DISORDERS.  22:e191.

Local anesthetics induce autophagy in young permanent tooth pulp cells.  Cell Death Discovery.  1.

Drp1 inhibition attenuates neurotoxicity and dopamine release deficits in vivo.  NATURE COMMUNICATIONS.  5.

Impaired Mitochondrial Dynamics and Nrf2 Signaling Contribute to Compromised Responses to Oxidative Stress in Striatal Cells Expressing Full-Length Mutant Huntingtin.  PLOS ONE.  8.

Neuronal adenosine release, and not astrocytic ATP release, mediates feedback inhibition of excitatory activity.  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.  109:6265-6270.

3.106 PARAQUAT NEUROTOXICITY IS MEDIATED BY THE DOPAMINE TRANSPORTER AND ORGANIC CATION TRANSPORTER-3.  PARKINSONISM & RELATED DISORDERS.  18:s190-s191.

3.246 BLOCKING DRP-1 FUNCTION IS NEUROPROTECTIVE IN ANIMAL MODELS OF PARKINSON'S DISEASE.  PARKINSONISM & RELATED DISORDERS.  18:s215.

3.260 D-β-HYDROXYBUTYRATE IS NEUROPROTECTIVE IN MOUSE MODELS OF HUNTINGTON'S DISEASE.  PARKINSONISM & RELATED DISORDERS.  18:s218.

Paraquat neurotoxicity is mediated by the dopamine transporter and organic cation transporter-3.  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.  108:20766-20771.

D-β-Hydroxybutyrate Is Protective in Mouse Models of Huntington's Disease.  PLOS ONE.  6.

A Guide to Neurotoxic Animal Models of Parkinson's Disease.  Cold Spring Harbor Perspectives in Medicine.  1.

Neurosteroid transport by the organic solute transporter OSTα-OSTβ.  JOURNAL OF NEUROCHEMISTRY.  115:220-233.

Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture.  Nature Neuroscience.  13:883-U130.

Perturbations in Mitochondrial Dynamics Induced by Human Mutant PINK1 Can Be Rescued by the Mitochondrial Division Inhibitor mdivi-1.  Journal of Biological Chemistry.  285:11740-11752.

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy.  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.  107:378-383.

Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture.  Deutsche Zeitschrift für Akupunktur.  53:38-39.

The organic cation transporter-3 is a pivotal modulator of neurodegeneration in the nigrostriatal dopaminergic pathway.  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.  106:8043-8048.

Silencing of the Pink1 gene expression by conditional RNAi does not induce dopaminergic neuron death in mice.  International Journal of Biological Sciences.  3:242-250.

Complex I deficiency primes Bax-dependent neuronal apoptosis through mitochondrial oxidative damage.  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.  102:19126-19131.

Ablation of the inflammatory enzyme myeloperoxidase mitigates features of Parkinson's disease in mice.  JOURNAL OF NEUROSCIENCE.  25:6594-6600.

MPTP as a mitochondrial neurotoxic model of Parkinson's disease.  Journal of Bioenergetics and Biomembranes.  36:375-379.

L-3-hydroxyacyl-CoA dehydrogenase II protects in a model of Parkinson's disease.  ANNALS OF NEUROLOGY.  56:51-60.

D-β-hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson disease.  Journal of Clinical Investigation.  112:892-901.

NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease.  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.  100:6145-6150.

Cyclooxygenase-2 is instrumental in Parkinson's disease neurodegeneration.  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.  100:5473-5478.

Free radical and nitric oxide toxicity in Parkinson's disease.  Advances in Neurology.  91:83-94.

Glial cell response: A pathogenic factor in Parkinson's disease.  Journal of NeuroVirology.  8:551-558.

Resistance of α-synuclein null mice to the parkinsonian neurotoxin MPTP.  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.  99:14524-14529.

Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease.  JOURNAL OF NEUROSCIENCE.  22:1763-1771.

The role of glial cells in Parkinson's disease.  CURRENT OPINION IN NEUROLOGY.  14:483-489.

Inhibition of 6-hydroxydopamine-induced p53 expression and survival of neuroblastoma cells following interaction with astrocytes.  NEUROSCIENCE.  103:125-132.

Differential effects of staurosporine and retinoic acid on the vulnerability of the SH-SY5Y neuroblastoma cells: Involvement of bcl-2 and p53 proteins.  Journal of Neuroscience Research.  58:426-435.

Neural Cell Adhesion Molecules.  Neuromethods.  33:103-130.

Aliphatic N-methylpropargylamines as potential neurorescue agents.  Restorative Neurology and Neuroscience.  12:113-118.

Preface.  xi-xii.

Cognitive impact of exposure to airborne particles captured by brain imaging.  29-45.

Chapter Eight Mitochondrial Dynamics in Neurodegenerative Diseases.  211-246.

Mitochondrial Dynamics in Neurodegenerative Diseases.  211-246.

Organic cation transporters as modulators of neurodegeneration and neuroprotection in the brain.  205-216.

Chapter 3 - Principles of Mitophagy and Beyond.  65-83.

Toxic animal models.  196-221.

Autophagy Plays a Key Role in the Loss of Nitric Oxide Signaling and Endothelial Dysfunction in Pulmonary Vascular Diseases.  CIRCULATION.

Upregulated Sphingosine-1-Phosphate Receptor 3 Disrupts Endothelial Cell Barrier and Mitochondrial Network Dynamics.  CIRCULATION.

Oxidative DNA Damage in Parkinson's Disease-Associated Genes..  ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. 75-75.

Drp1 inhibition ameliorates α-synuclein-mediated neurodegeneration in rats.  Movement Disorders. S245-S245.

ADENOSINE A1 RECEPTORS MEDIATE LOCAL ANTI-NOCICEPTIVE EFFECTS OF ACUPUNCTURE.  JOURNAL OF NEUROCHEMISTRY. 76-76.

Acupuncture induces release of adenine nucleotides and adensoine.  Purinergic Signalling. 69-69.

The analgesic effect of acupuncture is mediated by adenosine A1 receptors.  Purinergic Signalling. 161-162.

Mitochondrial defects induced by a loss of fusion effect in mutant PINK1 can be rescued through the fission/fusion pathway.  PARKINSONISM & RELATED DISORDERS. S174-S174.

Involvement of PI3-K/Akt signal pathway in acquired resistance against 6-OHDA in SH-SY5Ycell following interaction with astrocytes.  JOURNAL OF NEUROCHEMISTRY. 61-61.

COX-2 and neurodegeneration in Parkinson's disease.  ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 272-277.

Suppresion of p53 expression and increase in survival of SH-SY5Y cells in response to 6-hydroxydopamine in astrocytes cocultures.  JOURNAL OF NEUROCHEMISTRY. 83-83.

Effects of staurosporine and retinoic acid on the vulnerability of SH-SY5Y neuroblastoma cells to of bcl-2 and p53 genes..  JOURNAL OF NEUROCHEMISTRY. S137-S137.

Preface.  Advances in Neurotoxicology. xi-xii.

Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture.  Deutsche Zeitschrift für Akupunktur. 38-39.

A partial Drp1 knockout improves autophagy flux independent of mitochondrial function..  bioRxiv.

Autophagy Plays a Key Role in the Loss of Nitric Oxide Signaling and Endothelial Dysfunction in Pulmonary Vascular Diseases.  CIRCULATION. A13625-A13625.

Mitochondrial Hyperfusion Disrupts Carbohydrate Metabolism In Lung Endothelial Cells By Modifying The Activities Of Electron Transport Chain Complexes I And III.  FREE RADICAL BIOLOGY AND MEDICINE.

Mitochondrial redistribution of eNOS is regulated by CHIP mediated disruption of Dimerization.  FREE RADICAL BIOLOGY AND MEDICINE.

NAMPT induces Mitochondrial and Barrier Dysfunction in Pulmonary Endothelial Cells.  FREE RADICAL BIOLOGY AND MEDICINE.

S1PR3 Plays a Key Role in Ventilator-induced Lung Injury: Promoter Activation, Barrier Disruption, and Therapeutic Evaluation.  FREE RADICAL BIOLOGY AND MEDICINE.

Systemic effect of NF-kB-mediated Signaling Pathway Induced by Mechanosensitive Ca2+-Channel TRPV4 in Pulmonary Endothelial Cells.  FREE RADICAL BIOLOGY AND MEDICINE.

The anti-apoptotic protein, Survivin induces a shift in endothelial cell in carbon metabolism through a mitochondrial-ROS-dependent increase in HIF-1a signaling.  FREE RADICAL BIOLOGY AND MEDICINE.

Cytosolic PINK1 escapes form mitochondria to promote dendritic outgrowth.  JOURNAL OF NEUROCHEMISTRY. 787-789.

Cultured astrocytes do not release adenosine during hypoxic conditions.  JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. E1-E7.

Adenosine Mediates Anti-Nociceptive Effects of Acupuncture.  Forschende Komplementaermedizin: Wissenschaft Praxis Perspektiven. 347-347.

Pathogenic role of glial cells Parkinson's disease (vol 18, pg 121, 2003).  Movement Disorders. 118-118.

Imbalanced mitochondrial dynamics in human and mouse PD brains.

Sex and APOE Genotype Alter the Basal and Induced Inflammatory State of Primary Microglia from APOE Targeted Replacement Mice

Manganese-Induced Parkinsonism: Evidence from Epidemiological and Experimental Studies.  Biomolecules.

Exosomes in Parkinson disease.  JOURNAL OF NEUROCHEMISTRY. 413-428.

Mitochondria: A Common Target for Genetic Mutations and Environmental Toxicants in Parkinson's Disease.  FRONTIERS IN GENETICS.

Tipping Points and Endogenous Determinants of Nigrostriatal Degeneration by MPTP.  Trends in Pharmacological Sciences. 541-555.

Astrocytes and Therapeutics for Parkinson's Disease.  Neurotherapeutics. 413-423.

Glutathione dysregulation and the etiology and progression of human diseases.  Biological Chemistry. 191-214.

Nitric oxide and reactive oxygen species in Parkinson's disease.  IUBMB Life. 329-335.

Pathogenic role of glial cells in Parkinson's disease.  Movement Disorders. 121-129.