Characterizing urinary metabolites by non-targeted analysis and their associations with endogenous metabolism in children from South Florida
Article
Cappelini, LTD, Ferreira, VG, Ogunbiyi, OD et al. (2025). Characterizing urinary metabolites by non-targeted analysis and their associations with endogenous metabolism in children from South Florida
. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 120 10.1016/j.etap.2025.104877
Cappelini, LTD, Ferreira, VG, Ogunbiyi, OD et al. (2025). Characterizing urinary metabolites by non-targeted analysis and their associations with endogenous metabolism in children from South Florida
. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 120 10.1016/j.etap.2025.104877
Children are vulnerable to environmental contaminants due to physiological immaturity and behaviors that increase contact with exogenous compounds. These exposures can disrupt central metabolic pathways, potentially affecting development and long-term health. A non-targeted analysis approach and advanced chemical annotation tools was used to characterize environmental compounds and urinary metabolites in South Florida children, exploring possible interactions through correlation analyses. Urine samples from children aged 9 months to 6 years were processed by online solid-phase extraction (Online SPE) and analyzed by liquid chromatography high-resolution mass spectrometry (LC-HRMS), followed by molecular annotation using the Compound Discoverer software. Correlation analyses identified statistical associations between detected environmental compounds and endogenous metabolites. The results showed co-variation patterns suggesting possible metabolic changes involving amino acid metabolism, fatty acid oxidation, and neurotransmitter-related processes. Although no specific associations were found with compounds linked to ingestion, the data indicated broader biological disruptions, possibly from combined environmental and dietary exposures.
