Synthetic peptides related to the μ-receptor agonist, dermorphin Article

Sivanandaiah, KM, Suresh Babu, VV, Renukeshwar, HC et al. (1994). Synthetic peptides related to the μ-receptor agonist, dermorphin . Indian Journal of Pharmacology, 26(3), 204-208.

cited authors

  • Sivanandaiah, KM; Suresh Babu, VV; Renukeshwar, HC; Lakshmana, M; Asif, MA; Chiplunkar, S

abstract

  • Ten peptides related to the μ-receptor agonist, dermorphin (Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2) having structural modifications at positions 2,3,4 and 7 were synthesised by the solid phase method by using 9-fluorenylmethyloxycarbonyl (Fmoc)-amino acid trichlorophenyl (Tcp) ester as coupling agents and Merrifield resin as the solid support and their biological activities namely the effect on guinea pig ileum, the analgesic and the antidiarrhoeal activity were studied. The synthetic peptides were found to possess more antidiarrhoeal activity than any other activity and this is most pronounced in the analogues, (D-Met(O)2, MePhe3, Sar4, Tyr7) dermorphin and (D-Met(O)2, MePhe3, Sar4, Thr7) dermorphin.

authors

publication date

  • January 1, 1994

published in

start page

  • 204

end page

  • 208

volume

  • 26

issue

  • 3