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Impact of endocrine disrupting chemicals on birth outcomes Article

Chen Zee, E, Cornet, P, Lazimi, G et al. (2013). Impact of endocrine disrupting chemicals on birth outcomes . 41(10), 601-610. 10.1016/j.gyobfe.2013.08.012

cited authors

  • Chen Zee, E; Cornet, P; Lazimi, G; Rondet, C; Lochard, M; Magnier, AM; Ibanez, G

authors

abstract

  • Background Endocrine disruptors are ubiquitous chemicals contaminants in the environment, wildlife, and humans. Their adverse effects on reproduction are well-documented. There is growing evidence that they can contribute to the current emergence of chronic diseases. Objectives Our aim is to assess the relationships between endocrine disruptors and the neonatal health outcomes. Methods Two persons have independently reviewed Medline and Toxline databases about the following pollutants: bisphenol A, phthalates, parabens, brominated flame retardants and perfluorinated compounds. Only the human epidemiological studies, in general population with an abstract available, published between 2007 January the 1st and 2011 December the 31st, were analysed. The quality of each study was assessed with the Strobe score. Results Twenty-five out of 680 studies were included in the analysis. All pollutants were widely detected in maternal and new borns samples. Most of the studies have shown associations between bisphenol A, brominated flame retardants and perfluorinated compounds and lower birth weight. The effects on gestational age were less documented and have shown no clear connection. Results for phthalates were more ambiguous. Only one non-instructive study was found on parabens. Discussion Due to the inherent methological bias on endocrine disruptors research, further additional studies on environmental health must be investigated. It seems necessary to adopt preventive health measures first for vulnerable population. © 2013 Elsevier Masson SAS. All rights reserved.

publication date

  • January 1, 2013

Digital Object Identifier (DOI)

start page

  • 601

end page

  • 610

volume

  • 41

issue

  • 10