Exposome refers to the totality of environmental exposures an individual is exposed from the prenatal period and throughout the life course. Improved understanding about biological mechanisms through which the exposome may accelerate the aging process, increase disease occurrence, and/or lead to premature frailty is anticipated to contribute substantially towards the advancement of knowledge on the pathogenesis of frailty. The development of well-crafted theoretical frameworks to date, along with major advances in measurement technologies (e.g., omics approaches, wearable devices and sensors, bioinformatics for complex data analysis, etc.), provides now a robust basis to propel the emerging exposome-frailty area of investigation. In this chapter, we discuss the concept of exposome, the importance of the exposome-frailty line of investigation, summarize commonly used frameworks and measurements approaches, recognize the interface of exposome research and geroscience, and identify clinical and public health implications of exposome research relevant for frailty prevention.
