Combined paracetamol and ibuprofen for the study of analgesic activity of newly formulated dose in prospective pain management in Bangladesh
Article
Tabassum, A, Saha, RR, Rahman, MS et al. (2017). Combined paracetamol and ibuprofen for the study of analgesic activity of newly formulated dose in prospective pain management in Bangladesh
. 12(1), 1-13. 10.3923/jpt.2017.1.13
Tabassum, A, Saha, RR, Rahman, MS et al. (2017). Combined paracetamol and ibuprofen for the study of analgesic activity of newly formulated dose in prospective pain management in Bangladesh
. 12(1), 1-13. 10.3923/jpt.2017.1.13
Background and Objective: Pain management has been an area of a great deal of attention for pharmacists for many years. In this study, we report a study which is designed to investigate how a combination of existing effective drugs performs for the relief of pain management. Materials and Methods: A combined solid dosage containing paracetamol (500 mg) and ibuprofen (150 mg) is developed and tested under an observational analytical study. The performance of this combined oral solid dosage named maxigesic tablet in order to reduce pain is investigated on the basis of European patent specification. This assay is carried out by employing HPLC system with UV detection at 222 nm. Results: The results show the presence of active components to the tune of 112.12% for paracetamol and 101.86% for ibuprofen. The formulated solid dosage is further subjected to separate groups of artificially pain induced mice for a comparative study and it shows more efficacy than single analgesic used in pain management. We observe that the respective potencies for paracetamol and ibuprofenare 98.57 and 102.90%. Conclusion: The characterization of both granules and tablets of newly developed formulation demonstrates significant improvement in results of analytical test that not only met the standard specification, but they also reveal that the combined dosage will improve the product quality, efficacy and patient safety in the long run. This trial also shows a significant difference in the percentage of pain inhibition between the two sets of formulations (single and combination of them).
