Elevated serum lipocalin-2 is a risk factor of insulin resistance and for the progression of impaired glucose to type 2 diabetes in Bangladeshi population
Article
Rahman, MM, Hasan, MM, MasudRana et al. (2015). Elevated serum lipocalin-2 is a risk factor of insulin resistance and for the progression of impaired glucose to type 2 diabetes in Bangladeshi population
. 7(3), 9785-9794.
Rahman, MM, Hasan, MM, MasudRana et al. (2015). Elevated serum lipocalin-2 is a risk factor of insulin resistance and for the progression of impaired glucose to type 2 diabetes in Bangladeshi population
. 7(3), 9785-9794.
Background: Lipocalin-2 is a novel adipokine has effect on glucose metabolism. In this study, we investigate the association of serum Lipocalin-2 with insulin resistance in Bangladeshi population having impaired glucose. Methods: We estimated serum Lipocalin-2 and insulin in 171 Bangladeshi people by ELISA. Anthropometric parameters, glucose, HbA1c and lipid profile parameters were also measured. Result: Serum Lipocalin-2 was significantly elevated in the study subjects of impaired glucose tolerance and newly diagnosed type 2 diabetes compared to healthy control. In regression analysis, serum Lipocalin-2 concentration is independently and closely associated with the insulin resistance (HOMA-IR) in both IGT and NDD study groups (β =-0.249, p = 0.034, 95% CI -0.010 – 0.00 in IGT group and β = -0.237, p = 0.033, 95% CI -0.012 – 0.00 in NDD group) after adjustment of various confounding variables. Conclusion: Our findings predict that elevated serum Lipocalin-2 seems to have a contribution to the pathophysiology of insulin resistance and progression of impaired glucose to type 2 diabetes.
