Nanodisc-embedded cytochrome P450 P3A4 binds diverse ligands by distributing conformational dynamics to its flexible elements Article

Paco, Lorela, Hackett, John C, Atkins, William M. (2023). Nanodisc-embedded cytochrome P450 P3A4 binds diverse ligands by distributing conformational dynamics to its flexible elements . JOURNAL OF INORGANIC BIOCHEMISTRY, 244 10.1016/j.jinorgbio.2023.112211

Open Access

cited authors

  • Paco, Lorela; Hackett, John C; Atkins, William M

sustainable development goals

authors

publication date

  • July 1, 2023

published in

keywords

  • 3A4
  • ACTIVE-SITE
  • Biochemistry & Molecular Biology
  • Chemistry
  • Chemistry, Inorganic & Nuclear
  • ELECTRON-TRANSFER
  • HDX-MS
  • HOMOTROPIC COOPERATIVITY
  • HYDROGEN-EXCHANGE
  • Life Sciences & Biomedicine
  • Ligand-dependent effects
  • Lipid nanodiscs
  • MOLECULAR-DYNAMICS
  • ORGANIC-SOLVENTS
  • PHOSPHOLIPID-BILAYER NANODISCS
  • Physical Sciences
  • Protein flexibility
  • STRUCTURAL DYNAMICS
  • SUBSTRATE RECOGNITION
  • Science & Technology
  • Substrate promiscuity

Digital Object Identifier (DOI)

publisher

  • ELSEVIER SCIENCE INC

volume

  • 244