How do gangliosides regulate RTKs signaling?

How do gangliosides regulate RTKs signaling? Review

Julien, S, Bobowski, M, Steenackers, A et al. (2013). How do gangliosides regulate RTKs signaling? . Cells, 2(4), 751-767. 10.3390/cells2040751

Gangliosides, the glycosphingolipids carrying one or several sialic acid residues, are located on the outer leaflet of the plasma membrane in glycolipid-enriched microdomains, where they interact with molecules of signal transduction pathways including receptors tyrosine kinases (RTKs). The role of gangliosides in the regulation of signal transduction has been reported in many cases and in a large number of cell types. In this review, we summarize the current knowledge on the biosynthesis of gangliosides and the mechanism by which they regulate RTKs signaling. © 2013 by the authors; licensee MDPI, Basel, Switzerland.