Protective effect of madecassoside against cognitive impairment induced by d-galactose in mice Article

Lin, X, Zhang, S, Huang, R et al. (2014). Protective effect of madecassoside against cognitive impairment induced by d-galactose in mice . PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 124 434-442. 10.1016/j.pbb.2014.07.014

cited authors

  • Lin, X; Zhang, S; Huang, R; Wei, L; Tan, S; Liang, C; Lv, S; Chen, Y; Liang, S; Tian, Y; Lu, Z; Huang, Q

authors

abstract

  • This study was designed to investigate the protective effect of madecassoside from Hydrocotyle sibthorpioides against cognitive impairment induced by d-galactose (d-gal) in mice. The result revealed that treatment with madecassoside significantly reversed d-gal-induced learning and memory impairments, as measured by the Morris water-maze test. Studies on the potential mechanisms of this action showed that madecassoside significantly reduced oxidative stress and suppress inflammatory responses via blocking NF-κB and ERK/p38 MAPK pathways. Moreover, madecassoside markedly attenuated the content and deposition of β-amyloid peptide by inducing a decrease in the expression of amyloid protein precursor, β-site amyloid cleaving enzyme-1 and cathepsin B and an increase in the levels of neprilysin and insulin-degrading enzyme. Madecassoside significantly increased the expression of synapse plasticity-related proteins in the hippocampus, such as postsynaptic density 95, long-term potentiation, N-methyl-d-aspartic acid receptors, Ca 2 +/calmodulin-dependent protein kinase II, NMDA receptor subunit 1, protein kinase C, protein kinase A, cAMP-response element binding protein, and brain-derived neurotrophic factor. In addition, madecassoside significantly increased the levels of acetylcholine but decreased cholinesterase activity. In conclusion, the protective effect of madecassoside against d-gal-induced cognitive impairment was mainly due to its ability to reduce oxidative damage, improve synaptic plasticity and restore cholinergic function. These findings suggest that madecassoside can be considered as a potential agent for preventing cognitive impairment. © 2014 Elsevier Inc.

publication date

  • January 1, 2014

published in

Digital Object Identifier (DOI)

start page

  • 434

end page

  • 442

volume

  • 124