Posttranslational Regulation of Antisigma Factors of RpoE: A Comparison Between the escherichia Coli and Pseudomonas Aeruginosa Systems
Book Chapter
Pandey, S, Martins, KL, Mathee, K. (2016). Posttranslational Regulation of Antisigma Factors of RpoE: A Comparison Between the escherichia Coli and Pseudomonas Aeruginosa Systems
. 1 361-367. 10.1002/9781119004813.ch32
Pandey, S, Martins, KL, Mathee, K. (2016). Posttranslational Regulation of Antisigma Factors of RpoE: A Comparison Between the escherichia Coli and Pseudomonas Aeruginosa Systems
. 1 361-367. 10.1002/9781119004813.ch32
Posttranslational regulation of extracytoplasmic stress sigma factors, namely Pseudomonas aeruginosa AlgT/U and Escherichia coli RpoE, involves a series of proteases that leads to degradation of their cognate antisigma factors, MucA and RseA, respectively. MucA and RseA are both inner membrane proteins that are sequentially degraded in a process called regulated intramembrane proteolysis (RIP). RIP utilizes sequential cleavage of MucA-RseA by two inner membrane proteases: AlgW and MucP in P. aeruginosa, and DegS and RseP in E. coli. ClpXP removes the remaining cytoplasmic portion of the antisigma factor to release the sigma factor. The RIP cascade itself is triggered by extracellular, outer membrane, periplasmic stress, or peptide signals. Based on currently available data and in the absence of some of the homologs, two models, one for each species, is proposed.
