This chapter discusses some real-life blockchain-based applications and describes the applicability and necessity of integrating blockchain with the existing centralized systems. Particularly, we describe some widely popular domains where blockchain can be applied, i.e., healthcare, energy, finance, agriculture, smart city, smart manufacturing, e-voting, and personal identity management. To clearly understand the applications, we present visual representations of deploying blockchain’s conceptual understanding within those real-life applications. This chapter presents in detail how blockchain can be blended with those areas to provide a secure service highlighting the potential areas or domains for blockchain technology.