Carnitine homeostasis, mitochondrial function and cardiovascular disease Review

Sharma, S, Black, SM. (2009). Carnitine homeostasis, mitochondrial function and cardiovascular disease . Drug Discovery Today: Disease Mechanisms, 6(1-4), e31-e39. 10.1016/j.ddmec.2009.02.001

cited authors

  • Sharma, S; Black, SM

abstract

  • Carnitines are involved in mitochondrial transport of fatty acids and are of critical importance for maintaining normal mitochondrial function. This review summarizes recent experimental and clinical studies showing that mitochondrial dysfunction secondary to a disruption of carnitine homeostasis may play a role in decreased NO signaling and the development of endothelial dysfunction. Future challenges include development of agents that can positively modulate l-carnitine homeostasis which may have high therapeutic potential. © 2009 Elsevier Ltd. All rights reserved.

authors

publication date

  • March 10, 2009

published in

Digital Object Identifier (DOI)

start page

  • e31

end page

  • e39

volume

  • 6

issue

  • 1-4