Conductimetric detection of protein and cancer cells with oxide nanosensors Conference

Goud, J, Raj, PM, Liu, J et al. (2007). Conductimetric detection of protein and cancer cells with oxide nanosensors . 1010 126-131. 10.1557/proc-1010-v06-09

cited authors

  • Goud, J; Raj, PM; Liu, J; Iyer, M; Wang, ZL; Tummala, R

abstract

  • Semiconducting oxides are widely known and commercially applied for their gas sensing properties. However, biochemical sensing has mostly depended on optical and electrochemical techniques that are more cumbersome. This work investigates the biosensing characteristics of ZnO nanobelts and ZnO thin films. Zinc oxide thin film sensors showed changes in conductivity after protein functionalization with rabbit IgG and hybridization with anti-rabbit IgG. Conductivity changes were also measured after coating the oxides with anti-bodies to breast cancer cells (MCF-7) and hybridized with MCF-7 cells. In another set of experiments, ZnO nanobelts showed systematic conductivity changes with rabbit IgG protein hybridization. The experimental results in this paper indicate that the conductimetric properties of nano and thin film oxides can be sensitized to protein and cancer cell hybridization reactions. This technique can also be applied to certain other pathogen proteins or toxic proteins from the environment leading to low-cost miniaturized wireless biosensors. © 2007 Materials Research Society.

publication date

  • January 1, 2007

Digital Object Identifier (DOI)

International Standard Book Number (ISBN) 13

start page

  • 126

end page

  • 131

volume

  • 1010