Brain tissue characterization using Spectral Imaging: A potential clinical tool
Article
Mahadevan-Jansen, A, Mongin, JD, Jansen, ED et al. (2001). Brain tissue characterization using Spectral Imaging: A potential clinical tool
. SMART BIOMEDICAL AND PHYSIOLOGICAL SENSOR TECHNOLOGY XI, 4259 85-91. 10.1117/12.432484
Mahadevan-Jansen, A, Mongin, JD, Jansen, ED et al. (2001). Brain tissue characterization using Spectral Imaging: A potential clinical tool
. SMART BIOMEDICAL AND PHYSIOLOGICAL SENSOR TECHNOLOGY XI, 4259 85-91. 10.1117/12.432484
Spectral imaging as a modality combines two powerful techniques of imaging and fluorescence spectroscopy. By generating a 2-D image of an object with fluorescence information at every pixel, spectral imaging has the potential to provide clinicians with a valuable tool which can not only diagnosis the tissue but also provide an image of the boundary of where the normal and cancerous tissue intersect. The system used in these experiments was a modified spectral imaging system from Applied Spectral Imaging (SD-200, Carlsbad, CA). The system was mounted in an off-microscope configuration so that instead of performing microscopic measurements of tissue, macroscopic measurements on the order of several millimeters in size were collected. Preliminary results indicate that the spectra acquired from human brain tissues in vitro at individual pixels of the spectral image cube appear similar to that acquired using the single pixel system. Based on the findings of this study, spectral imaging has the potential to be a useful tool for tissue diagnosis and is currently limited by the speed of the data acquisition and size of the data.
