This chapter addresses every researcher's nightmare: what to do when you have null results. What does it mean? How can an investigator extract value from the data and move on in one's career from that point? The chapter starts with steps toward launching scientifically valid field research. The community intervention development model includes manualizing the protocol in the context of the practice setting, initial controlled efficacy trials, single-case applications, initial effectiveness tests, full effectiveness tests, and, finally, evaluating and disseminating results. The relationship with the host organization or practice setting is emphasized throughout.