Long-term biocompatibility of implanted polymer-based intrafascicular electrodes Article

Lawrence, SM, Larsen, JO, Horch, KW et al. (2002). Long-term biocompatibility of implanted polymer-based intrafascicular electrodes . Journal of Biomedical Materials Research - Part B Applied Biomaterials, 63(5), 501-506. 10.1002/jbm.10303

cited authors

  • Lawrence, SM; Larsen, JO; Horch, KW; Riso, R; Sinkjr, T

abstract

  • Polymer-based longitudinal intrafascicular electrodes (polyLIFEs) were chronically implanted into the sciatic nerve of white New Zealand rabbits (n=8) for a period of 6 months (hereafter referred to as the long-term group). The impact of the implantation procedure, as observed 6 months post surgery, was evaluated in a sham-treated control group (n=9). The contralateral sciatic nerve served as the control for each animal. Nerve-fiber counts, fiber diameters, and myelin thickness were estimated at the level of the implant site, 1.5 cm proximally, and 1.5 cm distally for both nerves in sham-treated and long-term groups. Implantation of polyLIFEs had no significant effect on fiber counts, nerve-fiber diameter, or myelin thickness. A slight increase in connective tissue in the vicinity of the implant site was evident in the long-term group, including a thin but dense capsule immediately surrounding the implanted electrode. © 2002 Wiley Periodicals, Inc.

authors

publication date

  • October 9, 2002

published in

Digital Object Identifier (DOI)

start page

  • 501

end page

  • 506

volume

  • 63

issue

  • 5