Simultaneous in vivo imaging of melanin and lipofuscin in the retina with multimodal photoacoustic ophthalmoscopy Conference

Zhang, X, Zhang, HF, Zhou, L et al. (2012). Simultaneous in vivo imaging of melanin and lipofuscin in the retina with multimodal photoacoustic ophthalmoscopy . 8223 10.1117/12.908820

cited authors

  • Zhang, X; Zhang, HF; Zhou, L; Jiao, S

authors

abstract

  • We combined photoacoustic ophthalmoscopy (PAOM) with autofluorescence imaging for simultaneous in vivo imaging of dual molecular contrasts in the retina using a single light source. The dual molecular contrasts come from melanin and lipofuscin in the retinal pigment epithelium (RPE). Melanin and lipofuscin are two types of pigments and are believed to play opposite roles (protective vs. exacerbate) in the RPE in the aging process. We successfully imaged the retina of pigmented and albino rats at different ages. The experimental results showed that multimodal PAOM system can be a potentially powerful tool in the study of age-related degenerative retinal diseases. © 2012 SPIE.

publication date

  • April 9, 2012

Digital Object Identifier (DOI)

International Standard Book Number (ISBN) 13

volume

  • 8223